Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Ralph A. Kelly"'
Autor:
Christian Kupatt, Keith M. Channon, Markus Schwaiger, Calin Vicol, E Kilian, Ravi Pillai, Sebastian Sadoni, Ralph A. Kelly, Bruno Reichart, Karen van Hulst, Roland Hetzer, Peter Boekstegers
Publikováno v:
Circulation Journal. 74:916-924
BACKGROUND Increasing numbers of patients with advanced coronary artery disease have limited options for percutaneous and/or surgical revascularization. A prospective, randomized, phase I clinical multicenter trial was performed to assess the feasibi
Publikováno v:
Current Pharmaceutical Design. 11:1279-1290
The immune system of higher vertebrates consists of two components: the innate and adaptive immunity. While the adaptive immune system relies on somatically generated and clonally selected antigen receptors, the innate immune system detects the prese
Publikováno v:
Circulation Research. 96:15-26
Activation of an innate immune response is among the first lines of defense after tissue injury. Restoring blood flow to the site of injured tissue is often a necessary prerequisite for mounting an initial immune response to pathogens and for subsequ
Autor:
Xiaoli Liu, Ralph A. Kelly, Jun-ichi Oyama, Todd Bourcier, Charles Blais, Minying Pu, Lester Kobzik
Publikováno v:
Circulation. 109:784-789
Background—Myocardial ischemia and reperfusion-induced tissue injury involve a robust inflammatory response, but the proximal events in reperfusion injury remain incompletely defined. Toll-like receptor 4 (TLR4) is a proximal signaling receptor in
Publikováno v:
Heart Failure Reviews. 7:327-334
Strong evidence links cardiomyocyte loss to the pathology of some forms of heart failure. Both necrotic and apoptotic modes of cell death have been invoked as the mechanism underlying progressive cardiomyocyte dropout. Nitric oxide (NO) has received
Autor:
Ralph A. Kelly, Thomas Michel, Charles I. Berul, Gordon K. Li, Amit Rakhit, T B S Colin Maguire, Josef Gehrmann, Hiroko Wakimoto
Publikováno v:
Journal of Cardiovascular Electrophysiology. 12:1295-1301
Electrophysiologic Studies in eNOS-Deficient Mice.Introduction: Endothelial nitric oxide synthase (eNOS) mediates attenuation of the L-type calcium channel and modulates myocyte contractility. Arrhythmogenic afterdepolarizations are seen in vitro in
Autor:
Thomas Fischer, Janice M. Pfeffer, Peter V. Finn, Krishna Singh, Stepan Gambaryan, Ralph A. Kelly, Egbert Flory, Stephan Ludwig, Marc A. Pfeffer
Publikováno v:
Hypertension. 37:1222-1228
Abstract —The role of mitogen-activated protein kinase (MAPK) pathways as signal transduction intermediates of hemodynamic stress leading to cardiac hypertrophy in the adult heart is not fully established. In a rat model of pressure-overload hypert
Autor:
Faiez Zannad, Carole Seguin, Paul-Michel Mertes, Ralph A. Kelly, Sandrine Grosjean, Yvan Devaux, Claude Meistelman, Dan Ungureanu-Longrois
Publikováno v:
Journal of Molecular and Cellular Cardiology. 33:933-945
S. Grosjean, Y. Devaux, C. Seguin, C. Meistelman, F. Zannad, P.-M. Mertes, R. A. Kelly and D. Ungureanu-Longrois. Retinoic Acid Attenuates Inducible Nitric Oxide Synthase (NOS2) Activation in Cultured Rat Cardiac Myocytes and Microvascular Endothelia
Publikováno v:
Circulation. 103:1459-1464
Background —Overloading the left ventricle in systole (pressure overload) is associated with a distinct morphological response compared with overload in diastole (volume overload). Methods and Results —We designed a novel computer-controlled expe
Publikováno v:
Journal of Biological Chemistry. 276:5197-5203
Growing evidence from patients with heart failure and from experimental animal models implicates effectors of innate immunity in the pathogenesis of this syndrome. The expression of the innate immunity signaling protein, Toll-like receptor 4 (TLR4),