Zobrazeno 1 - 10
of 353
pro vyhledávání: '"Ralph A Nixon"'
Autor:
Aidong Yuan, Linda Hassinger, Mala V Rao, Jean-Pierre Julien, Christopher C J Miller, Ralph A Nixon
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133848 (2015)
The axonal cytoskeleton of neurofilament (NF) is a long-lived network of fibrous elements believed to be a stationary structure maintained by a small pool of transported cytoskeletal precursors. Accordingly, it may be predicted that NF content in axo
Externí odkaz:
https://doaj.org/article/623849e6c57841869deebd682ceec246
Autor:
Wenjin Xu, Mirielle Lopez-Guzman, Chelsea Schoen, Shane Fitzgerald, Stephanie L Lauer, Ralph A Nixon, Efrat Levy, Donald A Wilson
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106431 (2014)
Alzheimer's disease is a neurodegenerative disorder that is the most common cause of dementia in the elderly today. One of the earliest reported signs of Alzheimer's disease is olfactory dysfunction, which may manifest in a variety of ways. The prese
Externí odkaz:
https://doaj.org/article/ca5070f7f80644b89768e7715830470a
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44320 (2012)
Newly synthesized neurofilaments or protofilaments are incorporated into a highly stable stationary cytoskeleton network as they are transported along axons. Although the heavily phosphorylated carboxyl-terminal tail domains of the heavy and medium n
Externí odkaz:
https://doaj.org/article/009d8f88548d45959554f78f83278ece
Autor:
Mala V Rao, Panaiyur S Mohan, Asok Kumar, Aidong Yuan, Lee Montagna, Jabbar Campbell, Veeranna, Enilza M Espreafico, Jean P Julien, Ralph A Nixon
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17087 (2011)
The neurofilament light subunit (NF-L) binds to myosin Va (Myo Va) in neurons but the sites of interaction and functional significance are not clear. We show by deletion analysis that motor domain of Myo Va binds to the NF-L rod domain that forms the
Externí odkaz:
https://doaj.org/article/fac9d01cedf14e71a245f7f955743511
Autor:
Belen Tizon, Susmita Sahoo, Haung Yu, Sebastien Gauthier, Asok R Kumar, Panaiyur Mohan, Matthew Figliola, Monika Pawlik, Anders Grubb, Yasuo Uchiyama, Urmi Bandyopadhyay, Ana Maria Cuervo, Ralph A Nixon, Efrat Levy
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9819 (2010)
Cystatin C (CysC) expression in the brain is elevated in human patients with epilepsy, in animal models of neurodegenerative conditions, and in response to injury, but whether up-regulated CysC expression is a manifestation of neurodegeneration or a
Externí odkaz:
https://doaj.org/article/b9db464fd7f9420fbe3b271004d02562
Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come
Autor:
John J. Alam, Ralph A. Nixon
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/352a7588129344b7834f30b68a70224d
Autor:
Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens, Ralph A. Nixon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show in an animal model and in a study in patients with dementia with Lewy bodies (DLB) that the drug neflamapimod has potential to treat diseases, such as DLB, associated with loss of neurons that produce the neurotransmitter acetylcholi
Externí odkaz:
https://doaj.org/article/435994d00b734e18a90ea82931cd1bac
Autor:
John J. Alam, Ralph A. Nixon
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/3002ca8325214009824d986c304c5a63
Autor:
Matteo Bordi, Rossella De Cegli, Beatrice Testa, Ralph A. Nixon, Andrea Ballabio, Francesco Cecconi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-7 (2021)
Abstract Autophagy is a highly dynamic and multi-step process, regulated by many functional protein units. Here, we have built up a comprehensive and up-to-date annotated gene list for the autophagy pathway, by combining previously published gene lis
Externí odkaz:
https://doaj.org/article/338415c43c534bd48426adcb5bf1eff0
Autor:
Aidong Yuan, Ralph A. Nixon
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Biomarkers of neurodegeneration and neuronal injury have the potential to improve diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy. Neurofilament proteins (NfPs) are well suited as biomarkers in these contexts becaus
Externí odkaz:
https://doaj.org/article/148100eb19ca42fcaba8439098631c2d