Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ralph A Neumüller"'
Autor:
Thomas Hoffmann, Alexandra Hörmann, Maja Corcokovic, Jakub Zmajkovic, Matthias Hinterndorfer, Jasko Salkanovic, Fiona Spreitzer, Anna Köferle, Katrin Gitschtaler, Alexandra Popa, Sarah Oberndorfer, Florian Andersch, Markus Schaefer, Michaela Fellner, Nicole Budano, Jan G Ruppert, Paolo Chetta, Melanie Wurm, Johannes Zuber, Ralph A Neumüller
Publikováno v:
eLife, Vol 12 (2023)
Loss-of-function genetic tools are widely applied for validating therapeutic targets, but their utility remains limited by incomplete on- and uncontrolled off-target effects. We describe artificial RNA interference (ARTi) based on synthetic, ultra-po
Externí odkaz:
https://doaj.org/article/5be3978b927a49d695b800fdcd6cb2bb
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
Autor:
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, Cornelia Schwarz, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Andreas Wernitznig, Jesse J Lipp, Kota Nagasaka, Petra van der Lelij, Gerd Bader, Minoru Koi, Ajay Goel, Ralph A Neumüller, Jan-Michael Peters, Norbert Kraut, Mark A Pearson, Mark Petronczki, Simon Wöhrle
Publikováno v:
eLife, Vol 8 (2019)
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite i
Externí odkaz:
https://doaj.org/article/bcf5373f995c49dd883a2b357adfa700
Autor:
Venu Thatikonda, Verena Supper, Johannes Wachter, Onur Kaya, Anju Kombara, Ceren Bilgilier, Madhwesh C. Ravichandran, Jesse J. Lipp, Rahul Sharma, Lukas Badertscher, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Sarah Grosche, Ralph A. Neumüller, Barbara Mair, Federico Mauri, Alexandra Popa
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114175- (2024)
Summary: Transcription factors (TFs) are important mediators of aberrant transcriptional programs in cancer cells. In this study, we focus on TF activity (TFa) as a biomarker for cell-line-selective anti-proliferative effects, in that high TFa predic
Externí odkaz:
https://doaj.org/article/cf2194b70a344373b2d1a869bceef1a4
Autor:
Sebastian Wissel, Anja Kieser, Tetsuo Yasugi, Peter Duchek, Elisabeth Roitinger, Joseph Gokcezade, Victoria Steinmann, Ulrike Gaul, Karl Mechtler, Klaus Förstemann, Jürgen A. Knoblich, Ralph A. Neumüller
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 8, Pp 2467-2478 (2016)
Traditional loss-of-function studies in Drosophila suffer from a number of shortcomings, including off-target effects in the case of RNA interference (RNAi) or the stochastic nature of mosaic clonal analysis. Here, we describe minimal in vivo GFP int
Externí odkaz:
https://doaj.org/article/094ae1132e5443c7b3805e8fa878a553
Autor:
Venu Thatikonda, Verena Supper, Madhwesh C. Ravichandran, Jesse J. Lipp, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Sara Grosche, Ralph A. Neumüller, Barbara Mair, Federico Mauri, Alexandra Popa
Transcription factors (TFs) are key components of the aberrant transcriptional programs in cancer cells. In this study, we used TF activity (TFa), inferred from the downstream regulons as a potential biomarker to identify associated genetic vulnerabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49167a733aa3def504d91a1b261f0825
https://doi.org/10.1101/2023.02.23.529701
https://doi.org/10.1101/2023.02.23.529701
Autor:
Xiankun Zeng, Lili Han, Shree Ram Singh, Hanhan Liu, Ralph A. Neumüller, Dong Yan, Yanhui Hu, Ying Liu, Wei Liu, Xinhua Lin, Steven X. Hou
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1226-1238 (2015)
The intestinal epithelium is the most rapidly self-renewing tissue in adult animals and maintained by intestinal stem cells (ISCs) in both Drosophila and mammals. To comprehensively identify genes and pathways that regulate ISC fates, we performed a
Externí odkaz:
https://doaj.org/article/1720ca25838943eab920d8d071602ed8
Autor:
Stefan Kornigg, Junwei Shi, Thomas Zichner, Janine Rippka, Stephan Karl Zahn, Christopher R. Vakoc, Mark Pearson, Gerd Bader, Silvia Blaha-Ostermann, Wolfgang Sommergruber, Mark Petronczki, Cornelia Schwarz, Norbert Kraut, Ralph A. Neumüller, Teresa Puchner, Alexandra Hörmann, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Norbert Schweifer, Ursula Strobl, Simon Wöhrle, Manfred Kögl
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
SMARCA4/BRG1 and SMARCA2/BRM, the two mutually exclusive catalytic subunits of the BAF complex, display a well-established synthetic lethal relationship in SMARCA4-deficient cancers. Using CRISPR-Cas9 screening, we identify SMARCA4 as a novel depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf48c313f689e413e0af35cf86b007ea
http://link.springer.com/article/10.1038/s41598-019-48152-x
http://link.springer.com/article/10.1038/s41598-019-48152-x
Autor:
Xiao-Ling Cockcroft, Stephan Karl Zahn, Mark Petronczki, Catherine M. Rogers, Fengling Li, Helmut Berger, Bernadette Sharps, Markus Zeeb, Ralph A. Neumüller, Mark Pearson, Dalia Barsyte-Lovejoy, Teresa Krammer, Oleg Fedorov, Barbara Müllauer, Alexander Weiss-Puxbaum, Kilian Huber, Masoud Vedadi, Magdalena M. Szewczyk, Christopher R. Vakoc, Abdellah Allali-Hassani, Tobias Wunberg, Steven Kennedy, Christoph Reiser, Michael Schleicher, Julian E. Fuchs, Cheryl H. Arrowsmith, Moriz Mayer, Jark Böttcher, Guido Boehmelt, Dietrich Böse, Alexandra Hörmann, Andreas Zoephel, Heribert Arnhof, Sandra Winkler, Darryl B. McConnell, Peter Brown, David Dilworth, Maja Corcokovic, Klaus Rumpel, Thomas Gerstberger, Nikolai Mischerikow, Carrow I. Wells, Ulrich Reiser, Daniela Häring
Publikováno v:
Nature Chemical Biology. 15:822-829
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is encoded by the WHSC1L1 gene located in the 8p11-p12 amplicon, frequently amplified in brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27dc86073fff4580d870ac18a39c74e3
https://doi.org/10.1038/s41589-019-0310-x
https://doi.org/10.1038/s41589-019-0310-x
Autor:
Birgit Wilding, Dirk Scharn, Dietrich Böse, Anke Baum, Valeria Santoro, Paolo Chetta, Renate Schnitzer, Dana A. Botesteanu, Christoph Reiser, Stefan Kornigg, Petr Knesl, Alexandra Hörmann, Anna Köferle, Maja Corcokovic, Simone Lieb, Guido Scholz, Jens Bruchhaus, Markus Spina, Josef Balla, Biljana Peric-Simov, Jasmin Zimmer, Sophie Mitzner, Thomas N. Fett, Alexandra Beran, Lyne Lamarre, Thomas Gerstberger, Daniel Gerlach, Markus Bauer, Andreas Bergner, Andreas Schlattl, Gerd Bader, Matthias Treu, Harald Engelhardt, Stephan Zahn, Julian E. Fuchs, Johannes Zuber, Peter Ettmayer, Mark Pearson, Mark Petronczki, Norbert Kraut, Darryl B. McConnell, Flavio Solca, Ralph A. Neumüller
Publikováno v:
Nature cancer. 3(7)
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in approximately 2% of patients with non-small cell lung cancer and predominantly affect the tyrosine kinase domain and cluster in exon 20 of the ERBB2 gene. Most clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57bd9ab03550201530aeff623cc359c
https://pubmed.ncbi.nlm.nih.gov/35883002
https://pubmed.ncbi.nlm.nih.gov/35883002
Autor:
Fiona Spreitzer, Corinna Wieshofer, Barbara Mair, Alexandra Popa, Christoph Reiser, Alexandra Hörmann, Andreas Schlattl, Sarah Oberndorfer, Venu Thatikonda, Anna Köferle, Ralph A. Neumüller, Teresa Puchner, Mark Pearson, Simon Wöhrle, Maja Corcokovic, Johannes Popow
Genetic networks are characterized by extensive buffering. During tumour evolution, disruption of these functional redundancies can create de novo vulnerabilities that are specific to cancer cells. In this regard, paralog genes are of particular inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1227f1a8fc42b44d97b2ca782bbe5f05
https://doi.org/10.1101/2021.05.21.445116
https://doi.org/10.1101/2021.05.21.445116