Výsledky vyhledávání - "Ralph, W. J."

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Health Profile of Young Adults Born Preterm: Negative Effects of Rapid Weight Gain in Early Life

Autor: Ralph W. J. Leunissen, Anita C. S. Hokken-Koelega, Petra E. Breukhoven, Gerthe F. Kerkhof, Ruben H. Willemsen

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 97(12), 4498-4506. Endocrine Society

Early postnatal weight gain is associated with determinants of cardiovascular disease (CVD) and type 2 diabetes mellitus (DM2) in adults born term. We aimed to investigate the association of weight gain during different periods, and weight trajectori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5550933c763d5d5a76c870395d63105
https://doi.org/10.1210/jc.2012-1716

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Pathways leading to artherosclerosis. A structural equation modeling approach in young adults

Autor: Ralph W. J. Leunissen, Gerthe F. Kerkhof, Anita C. S. Hokken-Koelega, Hugo J. Duivenvoorden

Publikováno v: Hypertension, 57, 255-260. Lippincott Williams & Wilkins

Several risk factors of cardiovascular diseases have been studied using direct association measures. Because the incidence of obesity and cardiovascular diseases is rising, it is important to correctly model these risk factors involved in development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8950934ee1846bbec432a0fd2268eb
https://pure.eur.nl/en/publications/5ae2175f-9750-40f1-a869-6d2970f351e2

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Preterm birth does not affect bone mineral density in young adults

Autor: Sandra W K de Kort, Ralph W. J. Leunissen, Ruben H. Willemsen, Petra E. Breukhoven, Anita C. S. Hokken-Koelega

Publikováno v: European Journal of Endocrinology, 164, 133-138. Bioscientifica Ltd

ObjectivePrevious studies showed conflicting data on the effect of prematurity on bone mineral density (BMD) in infants and children. Only a few studies investigated the long-term effects of prematurity on BMD in early adulthood. The objective of our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d2556db65b2b2abdba62f8a5da9842
https://doi.org/10.1530/eje-10-0573

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Central congenital hypothyroidism caused by maternal thyrotoxicosis

Autor: Daphne Peeters, Daniëlle C M van der Kaay, Ralph W. J. Leunissen, Sandra van Gijlswijk

Publikováno v: BMJ Case Reports. :bcr-2017

Central congenital hypothyroidism (CCH) is a rare and underdiagnosed disease that sometimes is caused by maternal Graves’ disease. We report a case of CCH caused by undiagnosed, initially antibody-negative maternal thyrotoxicosis with possible disr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2717ea44a92d8710d4c0e16dda373edb
https://doi.org/10.1136/bcr-2017-222620

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Serum insulin-like growth factor-Binding protein-2 levels and metabolic and cardiovascular risk factors in young adults and children born small for gestational age

Autor: Ad G. M. van de Sande, Anita C. S. Hokken-Koelega, Sandra W K de Kort, Jaap van Doorn, Ralph W. J. Leunissen

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 95(2), 864-871. Endocrine Society

IGF binding protein (IGFBP)-2 might protect against cardiovascular disease. Small for gestational age (SGA) birth could be associated with a higher risk for type 2 diabetes mellitus and cardiovascular disease in later life. No data are available on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19fa90fd9a74427245fa1a199cfd2fd
https://hdl.handle.net/1765/27345

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Insulin-Like Growth Factor-Binding Protein-1: Serum Levels, Promoter Polymorphism, and Associations with Components of the Metabolic Syndrome in Short Subjects Born Small for Gestational Age

Autor: Ralph W. J. Leunissen, Cheri Deal, Wietske A. Ester, Danielle C. M. van der Kaay, Anita C. S. Hokken-Koelega, Sandra W K de Kort, Jean Paquette, Jaap van Doorn, Ruben H. Willemsen

Publikováno v: Endocrine Research, 94(4), 1386-1392. Informa Healthcare

IGF binding protein (IGFBP)-1 is the only acute regulator of IGF-I bioavailability. Its production is suppressed by insulin, and low levels are associated with hyperinsulinemia and cardiovascular disease risk in adults. Data on IGFBP-1 levels in shor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef47ed232554b2b14de53a356f635947
https://doi.org/10.1210/jc.2008-1430

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Genetic and epigeneti variability in the gene for IGFBP-3 (IGFBP3): Correlation with serum IGFBP-3 levels and growth in short children born small for gestational age

Autor: D.C.M. van der Kaay, Cheri Deal, S. W. K. de Kort, Jean Paquette, Ralph W. J. Leunissen, Wietske A. Ester, Anita C. S. Hokken-Koelega, A.E.J. Hendriks, Ruben H. Willemsen

Publikováno v: Growth Hormone and IGF Research, 19, 198-205. Elsevier Ltd.

Context IGF-I and IGFBP-3 play a central role in fetal and postnatal growth and levels are low in short SGA children. The -202 A/C and -185 C/T SNPs are located near elements involved in directing IGFBP3 promoter activity and expression. Changes in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb66852f17360cd77293d825aeb36f29
https://pure.eur.nl/en/publications/720807d5-1fca-4e94-ac15-feb14b35bd30

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