Plasma pharmacokinetics of tigolaner, emodepside, and praziquantel following topical administration of a combination product (Felpreva®) and of intravenous administration of the individual active ingredients in cats

Autor: Norbert Mencke, Wolfgang Bäumer, Kristine Fraatz, Ralph Krebber, Marc Schneider, Katrin Blazejak

Publikováno v: Current Research in Parasitology and Vector-Borne Diseases, Vol 4, Iss , Pp 100126- (2023)

Felpreva® for cats contains the new acaricidal/insecticidal active ingredient tigolaner in a fixed combination with the nematocidal and cestocidal compounds emodepside and praziquantel, respectively. The plasma pharmacokinetics of tigolaner, emodeps

Externí odkaz: https://doaj.org/article/4cc6a17c865b4a53b7156aa76d48026a

Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis

Autor: Anouk Sarr, Carsten Terjung, Gabriele Schmuck, David D. Ekale, Daniel Kulke, Lucien Rufener, Vincent N. Tanya, Germanus S. Bah, John Graham-Brown, Nicolas H. Bayang, Helena Fieseler, Ralph Krebber, Steffen Hahnel, Benjamin L. Makepeace, Youssouf M. Mfopit, Sebastian Schneckener, Martin Glenschek-Sieberth, Henrietta F. Ngangyung

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 6, p e1009601 (2021)
PLOS PATHOGENS

Onchocerciasis (river blindness), caused by the filarial worm Onchocerca volvulus, is a neglected tropical disease mostly affecting sub-Saharan Africa and is responsible for >1.3 million years lived with disability. Current control relies almost enti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68a330cfa1483211b26a8215e4d5d72
http://europepmc.org/articles/PMC8202924

Toltrazuril treatment of congenitally acquired Neospora caninum infection in newborn mice

Autor: Gisela Greif, Andrew Hemphill, Norbert Müller, Ralph Krebber, Bruno Gottstein, Maria Strohbusch

Publikováno v: Strohbusch, M.; Muller, N.; Hemphill, A.; Krebber, R.; Greif, G.; Gottstein, B. (2009). Toltrazuril treatment of congenitally acquired Neospora caninum infection in newborn mice. Parasitology research, 104(6), pp. 1335-43. Berlin: Springer-Verlag 10.1007/s00436-009-1328-x

C57BL/6 mice were infected with Neospora caninum tachyzoites during pregnancy, yielding a transplacental infection of developing fetuses. Subsequently, congenitally infected newborn mice were treated either once or three times with toltrazuril (or pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef69ad3281aee7ec4a368783e3b6ea2
http://doc.rero.ch/record/320993/files/436_2009_Article_1328.pdf

A toxicokinetic and toxicodynamic modeling approach usingMyriophyllum spicatumto predict effects caused by short-term exposure to a sulfonylurea

Autor: Ralph Krebber, Simon Heine, Frederik Schild, Gerhard Görlitz, Walter Schmitt, Thomas G. Preuss

Publikováno v: Environmental Toxicology and Chemistry. 35:376-384

Toxicokinetic and toxicodynamic models are a promising tool to address the effects of time-variable chemical exposure. While standard toxicity tests rely, in most cases, on static concentrations, these chemical exposure patterns are unlikely to appea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e8d9c7aafa89c16cb312bbdaee32e9e
https://doi.org/10.1002/etc.3153

Simple and rapid determination of enrofloxacin and ciprofloxacin in edible tissues by turbulent flow chromatography/tandem mass spectrometry (TFC–MS/MS)

Autor: Franz-Jürgen Hoffend, Frank Ruttmann, Ralph Krebber

Publikováno v: Analytica Chimica Acta. 637:208-213

A simple and rapid method for the determination of residues of enrofloxacin and its metabolite ciprofloxacin in edible tissues of farm animals using turbulent flow chromatography/tandem mass spectrometry (TFC–MS/MS) is described. The tissue samples

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d71b708a16da95332692c7d2c6be8ab
https://doi.org/10.1016/j.aca.2008.11.006