Výsledky vyhledávání - "Ralph, Kühne"

Computational material flow analysis for thousands of chemicals of emerging concern in European waters

Autor: Ralph Kühne, Jos van Gils, Stela Kutsarova, John Munthe, Hans Baveco, Rudy Schueder, Claudia Lindim, Andreas Focks, Leo Posthuma, Ian T. Cousins, Janek Greskowiak, Annemarie P. van Wezel, Rolf Altenburger, Jaroslav Slobodnik, Dick de Zwart, Dik van de Meent, Arjen Markus, Gerrit Schüürmann, Werner Brack

Publikováno v: Journal of hazardous materials 397, 122655 (2020). doi:10.1016/j.jhazmat.2020.122655 special issue: "SI: Micropollutants in water / Edited by Sungpyo Kim, Sung Kyu Maeng, Jiangyong Hu, Shane Snyder, Despo Fatta-Kassinos"
Journal of Hazardous Materials 397 (2020)
Journal of Hazardous Materials, 397:122655. Elsevier
Journal of Hazardous Materials, 397

Journal of hazardous materials 397, 122655 (2020). doi:10.1016/j.jhazmat.2020.122655 special issue: "SI: Micropollutants in water / Edited by Sungpyo Kim, Sung Kyu Maeng, Jiangyong Hu, Shane Snyder, Despo Fatta-Kassinos"
Published by Science Dir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c82ed48f7ba0235eab05973b24d630
https://dare.uva.nl/personal/pure/en/publications/computational-material-flow-analysis-for-thousands-of-chemicals-of-emerging-concern-in-european-waters(7b724321-46d2-482f-a002-95b1189ba0cd).html

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PBT assessment under REACH: Screening for low aquatic bioaccumulation with QSAR classifications based on physicochemical properties to replace BCF in vivo testing on fish

Autor: Sebastian Strempel, Ralph Kühne, Anna Lombardo, Gerrit Schüürmann, Monika Nendza

Publikováno v: Science of The Total Environment. :97-106

Aquatic bioconcentration factors (BCFs) are critical in PBT (persistent, bioaccumulative, toxic) and risk assessment of chemicals. High costs and use of more than 100 fish per standard BCF study (OECD 305) call for alternative methods to replace as m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19e1fc497a9db0b3743804c44c6311f
https://doi.org/10.1016/j.scitotenv.2017.10.317

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Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH)

Autor: Joop de Knecht, Romanas Cesnaitis, Zhichao Dang, Ralph Kühne, Henrik Tyle, Stefan Scholz, Marta A. Sobanska, Anna-Maija Nyman, Simon Gutierrez Alonso, Wim De Coen, Claudio Carlon, Nils Klüver, Ivar Lundbergh

Publikováno v: Environmental Toxicology and Chemistry. 37:657-670

In 2013 the Organisation for Economic Co-operation and Development (OECD) test guideline (236) for fish embryo acute toxicity (FET) was adopted. It determines the acute toxicity of chemicals to embryonic fish. Previous studies show a good correlation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2bf4be185ed824728d54e682da94f8b
https://doi.org/10.1002/etc.4055

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Akademický článek

Prediction of Physicochemical Properties of Organic Compounds from 2D Molecular Structure – Fragment Methods vs. LFER Models

Autor: Gerrit Schüürmann, Ralf-Uwe Ebert, Ralph Kühne

Publikováno v: CHIMIA, Vol 60, Iss 10 (2006)

A large number of models is available to predict physicochemical properties directly from the two-dimensional molecular structure. An alternative to conventional fragment methods is given by linear free-energy relationships (LFERs) employing Abraham

Externí odkaz: https://doaj.org/article/1a132f92fd4844b3ba001d61581d109b

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Nontargeted detection and identification of (aromatic) amines in environmental samples based on diagnostic derivatization and LC-high resolution mass spectrometry

Autor: Ralph Kühne, Norbert Ost, Martin Krauss, Melis Muz, Gerrit Schüürmann, Werner Brack

Publikováno v: Chemosphere. 166:300-310

The presence of aromatic amines in the environment has been in the focus of research, as many of these compounds are known or suspected mutagens and carcinogens. To facilitate the detection of aromatic amines in complex environmental samples by LC-hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e91594c9bad9c3d4e93a0036ce4c31
https://doi.org/10.1016/j.chemosphere.2016.09.138

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Micropollutants in European rivers: A mode of action survey to support the development of effect-based tools for water monitoring

Autor: Wibke Busch, Martin Krauss, Tobias Schulze, Ralph Kühne, Susanne Schmidt, Rolf Altenburger

Publikováno v: Environmental Toxicology and Chemistry. 35:1887-1899

Environmental quality monitoring of water resources is challenged with providing the basis for safeguarding the environment against adverse biological effects from exposure to anthropogenic chemicals originating from diffuse and point sources. Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0de8455df54bc670125b53db943560bd
https://doi.org/10.1002/etc.3460

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Variation in predicted internal concentrations in relation to PBPK model complexity for rainbow trout

Autor: Vladimir Potemkin, Dominik Wondrousch, Gerrit Schüürmann, Elena Salmina, Ralph Kühne

Publikováno v: Science of The Total Environment. 550:586-597

The present study is motivated by the increasing demand to consider internal partitioning into tissues instead of exposure concentrations for the environmental toxicity assessment. To this end, physiologically based pharmacokinetic (PBPK) models can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c88f41ee1f571fc891f0e5659545f3
https://doi.org/10.1016/j.scitotenv.2016.01.107

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Inhalation threshold of toxicological concern (TTC) — Structural alerts discriminate high from low repeated-dose inhalation toxicity

Autor: Inga Tluczkiewicz, Ralph Kühne, Sylvia Escher, Gerrit Schüürmann, Ralf-Uwe Ebert

Publikováno v: Environment International, Vol 88, Iss, Pp 123-132 (2016)

The threshold of toxicological concern (TTC) of a compound represents an exposure value below which the associated human health risk is considered negligible. As such, this approach offers assessing the risk of potential toxicants when little or no t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6020fb300057e33334fc9b1c5fef872a
https://doi.org/10.1016/j.envint.2015.12.005

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