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Next generation sequencing of B cell receptor (BCR) repertoires has become a ubiquitous tool for understanding the antibody-mediated immune response: it is now common to have large volumes of sequence data coding for both the heavy and light chain su
Externí odkaz:
http://arxiv.org/abs/2203.11367
We are frequently faced with a large collection of antibodies, and want to select those with highest affinity for their cognate antigen. When developing a first-line therapeutic for a novel pathogen, for instance, we might look for such antibodies in
Externí odkaz:
http://arxiv.org/abs/2004.11868
The human body is able to generate a diverse set of high affinity antibodies, the soluble form of B cell receptors (BCRs), that bind to and neutralize invading pathogens. The natural development of BCRs must be understood in order to design vaccines
Externí odkaz:
http://arxiv.org/abs/1906.11982
Publikováno v:
PLoS Comput Biol 15(7): e1007133 (2019)
The collection of immunoglobulin genes in an individual's germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In humans, for example, each individual has only a fraction of the several
Externí odkaz:
http://arxiv.org/abs/1711.05843
The human immune system depends on a highly diverse collection of antibody-making B cells. B cell receptor sequence diversity is generated by a random recombination process called "rearrangement" forming progenitor B cells, then a Darwinian process o
Externí odkaz:
http://arxiv.org/abs/1603.08127
VDJ rearrangement and somatic hypermutation work together to produce antibody-coding B cell receptor (BCR) sequences for a remarkable diversity of antigens. It is now possible to sequence these BCRs in high throughput; analysis of these sequences is
Externí odkaz:
http://arxiv.org/abs/1503.04224
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Autor:
Dhar, Amrit1,2 (AUTHOR), Ralph, Duncan K.2 (AUTHOR), Minin, Vladimir N.3 (AUTHOR) vminin@uci.edu, Matsen IV, Frederick A.2 (AUTHOR) vminin@uci.edu
Publikováno v:
PLoS Computational Biology. 8/17/2020, Vol. 16 Issue 8, p1-27. 27p. 4 Diagrams, 2 Charts, 2 Graphs.
Autor:
Ralph, Duncan K.1 dkralph@gmail.com, IVMatsen, Frederick A.1
Publikováno v:
PLoS Computational Biology. 7/22/2019, Vol. 15 Issue 7, p1-30. 30p. 9 Diagrams, 1 Chart, 5 Graphs.
Akademický článek
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