Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ralf Zuhse"'
Autor:
Jan Kiebist, Kai-Uwe Schmidtke, Marina Schramm, Rosalie König, Stephan Quint, Johannes Kohlmann, Ralf Zuhse, René Ullrich, Martin Hofrichter, Katrin Scheibner
Publikováno v:
Journal of Fungi, Vol 7, Iss 9, p 752 (2021)
Antithrombotic thienopyridines, such as clopidogrel and prasugrel, are prodrugs that undergo a metabolic two-step bioactivation for their pharmacological efficacy. In the first step, a thiolactone is formed, which is then converted by cytochrome P450
Externí odkaz:
https://doaj.org/article/8d4c1b107522450a94ee6d7faa5716bd
Autor:
Jan Kiebist, Kerstin Hoffmann-Jacobsen, Christian Mayer, Kim N. Ingenbosch, Philipp Süss, Ute Liebelt, Klaus Opwis, Melanie Dyllick-Brenzinger, D.S. Wunschik, Katrin Scheibner, Ralf Zuhse, Jochen S. Gutmann, Ulf Menyes, Stephan Quint
Publikováno v:
Chembiochem
Singlet oxygen is a reactive oxygen species undesired in living cells but a rare and valuable reagent in chemical synthesis. We present a fluorescence spectroscopic analysis of the singlet‐oxygen formation activity of commercial peroxidases and nov
Publikováno v:
ChemistrySelect. 4:6469-6472
Autor:
Junichi Enoki, Andreas Liese, Carolin Mügge, Lutz Hilterhaus, Ralf Zuhse, Robert Kourist, Kenji Miyamoto, Miriam Assmann, Jasmin Wetzig, Sarah Katharina Gaßmeyer
Publikováno v:
ChemCatChem. 8:916-921
The bacterial decarboxylase (AMDase) catalyzes the enantioselective decarboxylation of prochiral arylmalonates with high enantioselectivity. Although this reaction would provide a highly sustainable synthesis of active pharmaceutical compounds such a
Autor:
Tom A. Ewing, Ralf Zuhse, Silvia Segarra, Marta Tortajada, Willem J. H. van Berkel, Jasmin Kühn
Publikováno v:
Advanced Synthesis and Catalysis 360 (2018) 12
Advanced Synthesis and Catalysis, 360(12), 2370-2376
Advanced Synthesis and Catalysis, 360(12), 2370-2376
The enantioselective oxyfunctionalisation of C−H bonds is a highly interesting reaction, as it provides access to chiral alcohols that are important pharmaceutical building blocks. However, it is hard to achieve using traditional methods. One way i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9affa037d5eab84d0af3982ab19512e6
https://research.wur.nl/en/publications/multigram-scale-enzymatic-synthesis-of-r-1-4-hydroxyphenylethanol
https://research.wur.nl/en/publications/multigram-scale-enzymatic-synthesis-of-r-1-4-hydroxyphenylethanol
Publikováno v:
Organic Process Research & Development. 19:369-372
Biocatalytic asymmetric reduction of ethyl-4,4,4-trifluoroacetoacetate under water-deficient reaction conditions using a “smart cosubstrate” 1,4-butanediol was demonstrated up to a 2 L scale. Substrate concentrations of 100 g/L were applied by us
Autor:
Ralf Zuhse, Andreas Vogel, Selin Kara, Paul Könst, Svenja Kochius, Hedda Merkens, Frank Hollmann, Isabel W. C. E. Arends, Dirk Holtmann
Publikováno v:
Angewandte Chemie. 124:10052-10055
Autor:
Ralf Zuhse, Hans-Ulrich Reissig, Caterina Murruzzu, Hans Christian Korting, Maja Natek, Monika Schäfer-Korting, Anja Schwanke, Barbara Zdrazil, Hans-Dieter Höltje, Monika Höltje
Publikováno v:
International Journal of Pharmaceutics. 397:9-18
Aiming to address new drug targets, molecular modelling is gaining increasing importance although the prediction capability of the in silico method is still under debate. For an improved treatment of actinic keratosis and squamous cell carcinoma, inh
Autor:
Isabel W. C. E. Arends, Dirk Holtmann, Selin Kara, Ralf Zuhse, Hedda Merkens, Paul Könst, Frank Hollmann, Andreas Vogel, Svenja Kochius
Publikováno v:
Angewandte Chemie (International ed. in English). 51(39)
Teaching old dogs new tricks: Alcohol dehydrogenases (ADHs) may be established redox biocatalysts but they still are good for a few surprises. ADHs can be used to oxidize aldehydes, and this was demonstrated by the oxidative dynamic kinetic resolutio
Publikováno v:
ChemInform. 23