Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Ralf Wienecke"'
Publikováno v:
Journal der Deutschen Dermatologischen Gesellschaft. 2:588-591
Zusammenfassung Vier Fallberichte von Patienten mit myeloproliferativem Syndrom, die zur Therapie Hydroxycarbamid (Synonyme: Hydroxyurea, Hydroxyharnstoff; Handelsnamen: Litalir®, Syrea®) einnehmen, und bei denen es einige Monate nach Beginn der Th
Autor:
Jeffrey E. DeClue, Steven Kaddu, Phuong-Anh Vu, Michael W. Johnson, Matthias Volkenandt, Harry V. Vinters, Christian A. Sander, Heidi Rust, Ingrid Fackler, Ralf Wienecke, Heinz Kutzner, Arno Rütten
Publikováno v:
Journal of Cutaneous Pathology. 30:174-177
Background: Angiofibromas occur sporadically, and they develop in most patients with tuberous sclerosis complex (TSC), which is associated with alterations of the tumor suppressor genes TSC1 or TSC2. Loss of tuberin, the protein product of TSC2, has
Autor:
Ralf Wienecke, Neil A. Swanson, Eckart Klemm, Sarolta Karparti, Jeffrey E. DeClue, Andrew Green
Publikováno v:
Journal of Cutaneous Pathology. 29:287-290
Background: Patients affected with tuberous sclerosis complex (TSC) are prone to the development of multiple benign tumors of the skin and other organs. Tuberin, the protein product of the tuberous-sclerosis-complex-2 tumor suppressor gene (TSC2) has
Autor:
Raymond S. Yeung, Ralf Wienecke, Jeffrey E. DeClue, Michael J. Flaig, Ingrid Fackler, Adelheid Rust, Christian A. Sander, Matthias Volkenandt, Phuong-Anh Nguyen-Vu
Publikováno v:
Journal of Cutaneous Pathology. 28:470-475
Background: Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited disorder associated with an alteration of the TSC2 tumor suppressor gene which encodes for the protein product tuberin. The disease is characterized by the development
Antitumoral Activity of Rapamycin in Renal Angiomyolipoma Associated With Tuberous Sclerosis Complex
Autor:
Ralf Wienecke, Ingrid Fackler, Karin Mayer, Ulrich Linsenmaier, Thomas Licht, Matthias Kretzler
Publikováno v:
American Journal of Kidney Diseases. 48:e27-e29
A 19-year old patient with tuberous sclerosis presented with a renal angiomyolipoma. Because animal trials of tuberous sclerosis showed an effect of rapamycin on renal tumors, our patient was administered rapamycin for 6 months. During this time, the
Publikováno v:
Journal of Biological Chemistry. 272:29301-29308
Tuberous sclerosis is an autosomal dominant disorder characterized by the development of benign growths in many tissues and organs. Linkage analysis revealed two disease-determining genes on chromosome 9 and chromosome 16. The TSC2 gene on chromosome
Publikováno v:
Oncogene. 15:1611-1616
Several inherited predisposition to cancer syndromes are associated with the development of nervous system tumors. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder in which affected individuals are at risk for developing astrocytoma
Publikováno v:
Proceedings of the National Academy of Sciences. 93:9154-9159
The Tsc2 gene, which is mutationally inactivated in the germ line of some families with tuberous sclerosis, encodes a large, membrane-associated GTPase activating protein (GAP) designated tuberin. Studies of the Eker rat model of hereditary cancer st
Publikováno v:
Journal of Biological Chemistry. 270:16409-16414
Tuberous sclerosis (TSC) is a human genetic syndrome characterized by the development of benign tumors in a variety of tissues, as well as rare malignancies. Two different genetic loci have been implicated in TSC; one of these loci, the tuberous scle
Publikováno v:
Journal of Clinical Microbiology. 41:1791-1793
MICs and minimal bactericidal concentrations (MBCs) were evaluated for the four antibiotics azithromycin, amoxicillin, ceftriaxone, and doxycycline against the three main genospecies of Borrelia burgdorferi sensu lato. In MBC testing, statistically s