Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ralf Thoma"'
Autor:
Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi, Martino L. Morella, Iris Ruf, Doris Brugger, Sophia von der Mark, Ralf Thoma, Arne Rufer, Dominik Heer, Nina Pfahler, Anton Jochner, Jens Niewoehner, Luise Wolf, Matthias Fueth, Martin Ebeling, Roberto Villaseñor, Yanping Zhu, Matthew C. Deen, Xiaoyang Shan, Zahra Ehsaei, Verdon Taylor, Ellen Sidransky, David J. Vocadlo, Per-Ola Freskgård, Ravi Jagasia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Mutations in glucocerebrosidase cause the lysosomal storage disorder Gaucher’s disease and are the most common risk factor for Parkinson’s disease. Therapies to restore the enzyme’s function in the brain hold great promise for treating
Externí odkaz:
https://doaj.org/article/dde4fa8e6e8a4bb89ade3a42cbcce8bb
Autor:
Florian Wanke, Simon Gutbier, Anna Rümmelin, Malte Steinberg, Lindsey D. Hughes, Mascha Koenen, Juliana Komuczki, Daniel Regan-Komito, Sagie Wagage, Julia Hesselmann, Ralf Thoma, Doris Brugger, Tony Christopeit, Hayian Wang, Floriane Point, Remy Hallet, Sourav Ghosh, Carla V. Rothlin, Christoph Patsch, Barbara Geering
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Abstract Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for tissue homeostasis. Professional phagocytes express a plethora of surface receptors enabling them to sense and engulf apoptotic cells, thus avoidin
Externí odkaz:
https://doaj.org/article/01cf059ac626494a908897f862c90ad3
Autor:
Paola Favuzza, Elena Guffart, Marco Tamborrini, Bianca Scherer, Anita M Dreyer, Arne C Rufer, Johannes Erny, Joerg Hoernschemeyer, Ralf Thoma, Georg Schmid, Bernard Gsell, Araceli Lamelas, Joerg Benz, Catherine Joseph, Hugues Matile, Gerd Pluschke, Markus G Rudolph
Publikováno v:
eLife, Vol 6 (2017)
Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a crucial component of a ternary complex, includ
Externí odkaz:
https://doaj.org/article/020ed0eebb0d43a8aea76fd5a4619c3b
Autor:
Eric J. Niesor, Christine Magg, Naoto Ogawa, Hiroshi Okamoto, Elisabeth von der Mark, Hugues Matile, Georg Schmid, Roger G. Clerc, Evelyne Chaput, Denise Blum-Kaelin, Walter Huber, Ralf Thoma, Philippe Pflieger, Makoto Kakutani, Daisuke Takahashi, Gregor Dernick, Cyrille Maugeais
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 12, Pp 3443-3454 (2010)
The mechanism by which cholesteryl ester transfer protein (CETP) activity affects HDL metabolism was investigated using agents that selectively target CETP (dalcetrapib, torcetrapib, anacetrapib). In contrast with torcetrapib and anacetrapib, dalcetr
Externí odkaz:
https://doaj.org/article/6b0ce888f3634531a2b4ff3ba44e3457
Autor:
Henrietta Dehmlow, Ralf Thoma, Armin Ruf, Narendra Panday, Elisabeth Von Der Mark, Olivier Morand, Hans Peter Märki, Manfred Kansy, Peter Hartman, Philippe Coassolo, Alexander Chucholowski, Denise Blum-Kaelin, Johannes Aebi, Jean Ackermann, Tanja Schulz-Gasch
Publikováno v:
CHIMIA, Vol 59, Iss 3 (2005)
Novel inhibitors of oxidosqualene cyclase (OSC) for the treatment of dyslipidemia are reported. Starting point for the chemistry program was a set of compounds derived from a fungicide project which, in addition to high affinity for OSC from Candida
Externí odkaz:
https://doaj.org/article/52a208c1b0c345b49b3846af115d21f8
Autor:
Anna Rümmelin, Malte Steinberg, Ralf Thoma, Simon Gutbier, Florian Wanke, Floriane Point, Hayian Wang, Barbara Geering, Sagie Wagage, Carla V. Rothlin, Doris Brugger, Christoph Patsch, Remy Hallet, Lindsey D. Hughes, Daniel Regan-Komito, Julia Hesselmann, Tony Christopeit, Sourav Ghosh, Mascha Koenen, Juliana Komuczki
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for tissue homeostasis. Professional phagocytes express a plethora of surface receptors enabling them to sense and engulf apoptotic cells, thus avoiding persist
Autor:
Clara Schweiker, Sergej Zankovic, Anna Baghnavi, Dirk Velten, Hagen Schmal, Ralf Thomann, Michael Seidenstuecker
Publikováno v:
Frontiers in Drug Delivery, Vol 4 (2024)
Externí odkaz:
https://doaj.org/article/10fadc3f44ee4ed1a29fa511a7bca940
Autor:
Clara Schweiker, Sergej Zankovic, Anna Baghnavi, Dirk Velten, Hagen Schmal, Ralf Thomann, Michael Seidenstuecker
Publikováno v:
Frontiers in Drug Delivery, Vol 4 (2024)
The core/shell 3D printing process using CPC and alginate is intended to create biodegradable scaffolds that have a similar stability to bone tissue and also offer sufficient and continuous antibiotic release. In this way, a patient-specific and pati
Externí odkaz:
https://doaj.org/article/b736270d003843e194f1a39f186d2e31
Autor:
Itxaso Bellon-Echeverria, Andrea Araujo Del Rosario, Jean Philippe Carralot, Imre Berger, Georg Schmid, Ralf Thoma, Harald Mauser, Stephanie Kueng
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Bellón-Echeverría, I, Carralot, J P, Del Rosario, A A, Kueng, S, Mauser, H, Schmid, G, Thoma, R & Berger, I 2018, ' MultiBacMam Bimolecular Fluorescence Complementation (BiFC) tool-kit identifies new small-molecule inhibitors of the CDK5-p25 protein-protein interaction (PPI) ', Scientific Reports, vol. 8, 5083 . https://doi.org/10.1038/s41598-018-23516-x
Scientific Reports
Bellón-Echeverría, I, Carralot, J P, Del Rosario, A A, Kueng, S, Mauser, H, Schmid, G, Thoma, R & Berger, I 2018, ' MultiBacMam Bimolecular Fluorescence Complementation (BiFC) tool-kit identifies new small-molecule inhibitors of the CDK5-p25 protein-protein interaction (PPI) ', Scientific Reports, vol. 8, 5083 . https://doi.org/10.1038/s41598-018-23516-x
Protein-protein interactions (PPIs) are at the core of virtually all biological processes in cells. Consequently, targeting PPIs is emerging at the forefront of drug discovery. Cellular assays which closely recapitulate native conditions in vivo are
Autor:
Dominique Burger, Guillaume A. Schoch, Toon Laeremans, David C. Fry, Ashwani Sharma, Jörg Benz, Michel O. Steinmetz, Ralf Thoma, Armin Ruf, Jan Steyaert, Alfred Ross, Thomas Kremer, Paola Di Lello, Hugues Matile, Maja Debulpaep, Arne C. Rufer, Walter Huber, Brigitte D'Arcy, Martine Stihle, Markus G. Rudolph
Publikováno v:
Journal of Biological Chemistry
Doublecortin is a microtubule-associated protein produced during neurogenesis. The protein stabilizes microtubules and stimulates their polymerization, which allows migration of immature neurons to their designated location in the brain. Mutations in