Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ralf Spörle"'
An RNA interference phenotypic screen identifies a role for FGF signals in colon cancer progression.
Autor:
Marc Leushacke, Ralf Spörle, Christof Bernemann, Antje Brouwer-Lehmitz, Johannes Fritzmann, Mirko Theis, Frank Buchholz, Bernhard G Herrmann, Markus Morkel
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23381 (2011)
In tumor cells, stepwise oncogenic deregulation of signaling cascades induces alterations of cellular morphology and promotes the acquisition of malignant traits. Here, we identified a set of 21 genes, including FGF9, as determinants of tumor cell mo
Externí odkaz:
https://doaj.org/article/61c4d04199884c3696add6a3c54a6b40
Publikováno v:
Gene Expression Patterns. 7:370-374
Neurite outgrowth (e.g. axonal or dendrite outgrowth) of neurons is necessary for the development and functioning of the central nervous system. It is well accepted that the differentiation of neurons and neurite outgrowth involve alterations in gene
Autor:
Bernhard Strauss, Gerd B. Müller, Johannes Streicher, Ralf Spörle, Markus A. Donat, Klaus Schughart
Publikováno v:
Nature Genetics. 25:147-152
A broad understanding of the relationship between gene activation, pattern formation and morphogenesis will require adequate tools for three-dimensional and, perhaps four-dimensional, representation and analysis of molecular developmental processes.
Autor:
Klaus Schughart, Ralf Spörle
Publikováno v:
Developmental Genetics. 22:359-373
In open brain (opb) mutant embryos, developmental defects of the trunk spinal cord were spatially correlated with severe defects of the epaxial somite derivatives including sclerotomes, whereas hypaxial somite derivatives are much less affected. Late
Autor:
Ralf Spörle, Klaus Schughart
Publikováno v:
Developmental Dynamics. 210:216-226
The identification of the axial levels of metameric elements along the rostro-caudal axis of vertebrates until now was not possible before late, fetal development, when the vertebral anlagen first appear. We developed a new system for the exact axial
Autor:
Tobias Nolden, Hans Lehrach, Heinz Himmelbauer, Joachim Wittbrodt, Florian Mertes, Ralf Spörle, Juan Ramón Martínez-Morales
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
6 páginas, 4 figuras, 1 tabla de sequencia de datos (NCBI accession number EU683438).
Ojoplano (Opo) is a morphogenetic gene playing an important role during embryogenesis in medaka. This report focuses on the identification and characterizatio
Ojoplano (Opo) is a morphogenetic gene playing an important role during embryogenesis in medaka. This report focuses on the identification and characterizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981ade493a681d7b51c99a936b0d3a46
http://hdl.handle.net/10261/41586
http://hdl.handle.net/10261/41586
Autor:
Ralf Spörle
Publikováno v:
Development genes and evolution. 211(4)
During vertebrate neural tube formation, the initially lateral borders between the neural and epidermal ectoderm fuse to form the definitive dorsal region of the embryo, while the initially dorsally located notochord-floor plate complex is being inte
Publikováno v:
Genomics. 57(2)
The frizzled gene family is conserved from insects to mammals and codes for putative Wnt receptors that share a cysteine-rich extracellular domain and seven transmembrane domains. We previously identified a novel frizzled gene, FZD3, now renamed FZD9
Autor:
Klaus Schughart, Christina Grimm, Ilse-Dore Adler, Ralf Spörle, Thomas E. Schmid, Jochen Graw, Jerzy Adamski
Publikováno v:
Hum. Mol. Genet. 8, 697-710 (1999)
Scopus-Elsevier
Scopus-Elsevier
The human gene HIC1 (hypermethylated in cancer) maps to chromosome 17p13.3 and is deleted in the contiguous gene disorder Miller-Dieker syndrome (MDS) [Makos-Wales et al. (1995) Nature Med., 1, 570-577; Chong et al. (1996) Genome Res., 6, 735-741]. W
Autor:
Shahragim Tajbakhsh, Ralf Spörle
Publikováno v:
Cell. 92(1)
We thank our colleagues M. Buckingham, G. Cossu, O. Pourquie, and K. Schughart and participants at the meeting for their many insightful comments. We also thank Didier Rocancourt for artwork. We regret that not all primary references could be cited d