Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ralf Schröder"'
Autor:
Ralf Schröder, Luzheng Xue, Viktoria Konya, Lene Martini, Nora Kampitsch, Jennifer L Whistler, Trond Ulven, Akos Heinemann, Roy Pettipher, Evi Kostenis
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33329 (2012)
Prostaglandin H(1) (PGH(1)) is the cyclo-oxygenase metabolite of dihomo-γ-linolenic acid (DGLA) and the precursor for the 1-series of prostaglandins which are often viewed as "anti-inflammatory". Herein we present evidence that PGH(1) is a potent ac
Externí odkaz:
https://doaj.org/article/a776db4b8f144f759e59d2a198adaf12
Autor:
Alois Hollerweger, Michael Hoffmann, Claus-Peter Trimborn, K. Dirks, Matthias Anthuber, Sarah Förster, Andrea Tannapfel, Ralf Schröder, Jörg C. Hoffmann
Acute appendicitis (AA) is amongst the most common causes of acute abdominal pain. In spite of progress based on risk stratifications, “negative” appendectomies are performed in up to 30% of patients whilst the appendix perforates in others. Preo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4b6986271f63f7b1de7fcc8793bf28
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/91134
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/91134
Autor:
Frank Halter, Ralf Schröder
Das St. Galler Nachfolge-Modell ist ein Rahmenkonzept für eine ganzheitliche Unternehmensnachfolge. Es richtet sich an Unternehmerinnen und Unternehmer, Beraterinnen und Berater sowie Studierende, die sich differenziert mit dem Thema der Unternehmen
Autor:
Evi Kostenis, Jesus Gomeza, Theresa Bödefeld, Anne-Gaelle Letombe, Michel Gillard, Ramona Schrage, Qing Richard Lu, Liguo Zhang, Julia Fischer, Nicole Merten, Klaus Mohr, Ralf Schröder, Katharina Simon, Celine Vermeiren, Oliver Brüstle, Lucas Peters, Stephanie Hennen
Publikováno v:
Cell chemical biology. 25(6)
Identification of additional uses for existing drugs is a hot topic in drug discovery and a viable alternative to de novo drug development. HAMI3379 is known as an antagonist of the cysteinyl-leukotriene CysLT(2) receptor, and was initially developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1c8d719c8ff159b38452208b5164c2
https://pubmed.ncbi.nlm.nih.gov/29706593
https://pubmed.ncbi.nlm.nih.gov/29706593
Autor:
Suvi Annala, Markus Kuschak, Daniela Wenzel, Evi Kostenis, Christa E. Müller, Bernd K. Fleischmann, Alexander Seidinger, Annika Simon, Gabriele M. König, Richard E. Roberts, Ralf Schröder, Ian P. Hall, Michaela Matthey
Publikováno v:
Science Translational Medicine. 9
Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of Gq protein–dependent signaling cascades. Currently, drugs targeting single G protein (heterotrimeric guanine nucleotide–bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4f4aae81e119fb1396df1599b306ff3
https://doi.org/10.1126/scitranslmed.aag2288
https://doi.org/10.1126/scitranslmed.aag2288
Autor:
Ralf Schröder, Evi Kostenis, Rafael Franco, José Manuel Pérez-Ortiz, Miriam Peinhaupt, Nariman Balenga, Marta Zamarbide, Akos Heinemann, Ana Ricobaraza, Zoltán Bálint, Eva Martínez-Pinilla, Wolfgang Platzer, Maria Waldhoer, Iria G. Dopeso-Reyes, Julia Kargl
Publikováno v:
British Journal of Pharmacology. 171:5387-5406
Background and Purpose Heteromerization of GPCRs is key to the integration of extracellular signals and the subsequent cell response via several mechanisms including heteromer-selective ligand binding, trafficking and/or downstream signalling. As the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db1268d36f4254654cf9d2545359386f
https://doi.org/10.1111/bph.12850
https://doi.org/10.1111/bph.12850
Autor:
Stephanie Hennen, Philip Preis, Ramona Schrage, Celine Vermeiren, Katharina Simon, Nicole Merten, Ralf Schröder, Klaus Mohr, Michel Gillard, Evi Kostenis, Lucas Peters, Jesus Gomeza, Nina-Katharina Schmitt
Publikováno v:
Molecular pharmacology. 91(5)
Pairing orphan G protein–coupled receptors (GPCRs) with their cognate endogenous ligands is expected to have a major impact on our understanding of GPCR biology. It follows that the reproducibility of orphan receptor ligand pairs should be of funda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f8bbe55bd520771be26a21ee292fa6
https://pubmed.ncbi.nlm.nih.gov/28550097
https://pubmed.ncbi.nlm.nih.gov/28550097
Autor:
Michaela, Matthey, Richard, Roberts, Alexander, Seidinger, Annika, Simon, Ralf, Schröder, Markus, Kuschak, Suvi, Annala, Gabriele M, König, Christa E, Müller, Ian P, Hall, Evi, Kostenis, Bernd K, Fleischmann, Daniela, Wenzel
Publikováno v:
Science translational medicine. 9(407)
Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::091e173dd373141180278774f312d2f7
https://pubmed.ncbi.nlm.nih.gov/29081526
https://pubmed.ncbi.nlm.nih.gov/29081526
Autor:
Christian Urban, Evi Kostenis, Ralf Schröder, Graeme Milligan, Matthias U. Kassack, Michael A. Cawthorne, Trond Ulven, Brian D. Hudson, Elisabeth Christiansen, Maria E Due-Hansen, Manuel Grundmann
Publikováno v:
Christiansen, E, Due-Hansen, M E, Urban, C, Grundmann, M, Schröder, R, Hudson, B D, Milligan, G, Cawthorne, M A, Kostenis, E, Kassack, M U & Ulven, T 2012, ' Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists : Mesylpropoxy Appendage Lowers Lipophilicity and Improves ADME Properties ', Journal of Medicinal Chemistry, vol. 55, no. 14, pp. 6624-8 . https://doi.org/10.1021/jm3002026
FFA1 (GPR40) is a new target for treatment of type 2 diabetes. We recently identified the potent FFA1 agonist TUG-469 (5). Inspired by the structurally related TAK-875, we explored the effects of a mesylpropoxy appendage on 5. The appendage significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce220e64a278c42d1bd03d439ed683d8
https://doi.org/10.1021/jm3002026
https://doi.org/10.1021/jm3002026
Autor:
Petra Luschnig, Angel Gonzalez, Leonardo Pardo, Akos Heinemann, Stephanie Hennen, Klaus Mohr, Ralf Schröder, Michael Gütschow, Evi Kostenis, Viktoria Konya, Rahul Tyagi, Andreas Bock, Trond Ulven, Philipp A. Ottersbach, Lucas Peters, C. David Weaver, Jürgen Gäb, Stefanie Blättermann
Publikováno v:
Blättermann, S, Peters, L, Ottersbach, P A, Bock, A, Konya, V, Weaver, C D, Gonzalez, A, Schröder, R, Tyagi, R, Luschnig, P, Gäb, J, Hennen, S, Ulven, T, Pardo, L, Mohr, K, Gütschow, M, Heinemann, A & Kostenis, E 2012, ' A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer ', Nature Chemical Biology, vol. 8, no. 7, pp. 631-638 . https://doi.org/10.1038/nchembio.962
Differential targeting of heterotrimeric G protein versus β-arrestin signaling are emerging concepts in G protein-coupled receptor (GPCR) research and drug discovery, and biased engagement by GPCR ligands of either β-arrestin or G protein pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d200f0bdcc5b9ed560cdbd77972f84b
https://doi.org/10.1038/nchembio.962
https://doi.org/10.1038/nchembio.962