Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ralf Paul"'
Autor:
Johanna K. Ahlskog, Antti Pohjakallio, Ralf Paul, Martin Augustin, Elisabeth Schneider, Sakshi Johri, Tuomas Tervahauta, Hans-Georg Beisel, Lars Neumann, Julia Lindqvist, Anu Moilanen
Publikováno v:
Cancer Research. 83:6179-6179
Background: DNA Polymerase θ (Polθ) is active in Theta-mediated end joining (TMEJ), a repair pathway that utilizes resected 3’ ends and micro-homology sequences to repair double strand breaks. Polθ contains an N-terminal helicase domain and a C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a398847ea3513ad142d5cc706bdaf5e
https://doi.org/10.1158/1538-7445.am2023-6179
https://doi.org/10.1158/1538-7445.am2023-6179
Autor:
Sofia Karlstrom, Hongtao Zhao, Kevin E. B. Parkes, Ralf Paul, Mikaela Rapp, Dean Derbyshire, Kerstin Böhm, Mari Kullman-Magnusson, Olof Engström, Oscar Belda, Ian R. Henderson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127471
Ubiquitin specific protease-7 (USP7) is considered an attractive target for cancer therapy by promoting degradation of the tumor suppressor p53 and negatively affecting the immune response to tumors. However, the development of selective non-covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60af20452db2d6af002b3dc1d649279a
https://doi.org/10.1016/j.bmcl.2020.127471
https://doi.org/10.1016/j.bmcl.2020.127471
Autor:
Ralf Paul, Marc Folcher, Markus Meuwly, Urs Jenal, Matthias Christen, Franziska F.-F. Schmid, Paul Jenoe, Beat Christen
Publikováno v:
Journal of Biological Chemistry. 281:32015-32024
Cyclic di-guanosine monophosphate is a bacterial second messenger that has been implicated in biofilm formation, antibiotic resistance, and persistence of pathogenic bacteria in their animal host. Although the enzymes responsible for the regulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f7039b99cb76d983e971dd82eb9a37
https://doi.org/10.1074/jbc.m603589200
https://doi.org/10.1074/jbc.m603589200
Autor:
Nicholas C. Amiot, Carmen Chan, Stefan Weiser, Bernd Giese, Ralf Paul, Urs Jenal, Tilman Schirmer
Publikováno v:
Genes & Development. 18:715-727
Pole development is coordinated with the Caulobacter crescentus cell cycle by two-component signaling proteins. We show that an unusual response regulator, PleD, is required for polar differentiation and is sequestered to the cell pole only when it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4ab5efb02a4fc7734449e8813b5d20
https://doi.org/10.1101/gad.289504
https://doi.org/10.1101/gad.289504
Publikováno v:
Molecular Microbiology. 47:1695-1708
Several members of the two-component signal transduction family have been implicated in the control of polar development in Caulobacter crescentus: PleC and DivJ, two polarly localized histidine sensor kinases; and the response regulators DivK and Pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce4984e0afaa47c183401ec2c53d1b6
https://doi.org/10.1046/j.1365-2958.2003.03401.x
https://doi.org/10.1046/j.1365-2958.2003.03401.x
Publikováno v:
Protein expression and purification. 110
The large scale screening of cytokine mutants is a component of binding and activity mapping and requires an efficient method of cytokine protein expression. Here, we compared recombinant IL-7 expression with and purification from Escherichia coli an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471fffd6a3ed0d89752095b30f485c68
https://pubmed.ncbi.nlm.nih.gov/25703052
https://pubmed.ncbi.nlm.nih.gov/25703052
Publikováno v:
Biophysical Journal. 106(2)
Type 1 diabetes (T1D) is characterized as a chronic autoimmune disease caused by a selective inflammatory destruction of the insulin producing beta cells in the pancreatic islets of Langerhans. Closely associated to T1D are insulin autoantibodies (IA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c608eb2e72fa54052cbe468b706c88b
Publikováno v:
Giesserei; Apr2022, Issue 4, p82-87, 6p
Autor:
Urs Jenal, Irene Wiederkehr, Tina Jaeger, Ralf Paul, Emanuele G. Biondi, Marc Folcher, Michael T. Laub, Sören Abel
Publikováno v:
Cell. 133(5)
SummaryThe two-component phosphorylation network is of critical importance for bacterial growth and physiology. Here, we address plasticity and interconnection of distinct signal transduction pathways within this network. In Caulobacter crescentus an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a36f50b713ab46651590925dbf0b275