Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ralf P. Brueckner"'
Autor:
Douglas B. Tang, David J. Braitman, Ralf P. Brueckner, Watcharee Chokejindachai, John Horton, Thomas G. Brewer, D. Gray Heppner, Polrat Wilairatana, Parnpen Viriyavejakul, Wilbur K. Milhous, Douglas S. Walsh, Sornchai Looareesuwan, Brian G. Schuster, Dennis E. Kyle
Publikováno v:
The Journal of Infectious Diseases. 180:1282-1287
WR 238605 is an 8-aminoquinoline developed for the radical cure of Plasmodium vivax. Forty-four P. vivax-infected patients were randomly assigned to 1 of 4 treatment regimens: 3 groups received a blood schizonticidal dose of chloroquine followed by W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa062c43e023532321e94921e3398b9
https://doi.org/10.1086/315034
https://doi.org/10.1086/315034
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 58:645-649
WR 238605 is an 8-aminoquinoline drug currently under development for prophylaxis and treatment of malaria. Preclinical studies have demonstrated that it has greater efficacy and less toxicity compared with primaquine. In this first-time-in-human ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee45c0aad43b23d5cc51f925267121c1
https://doi.org/10.4269/ajtmh.1998.58.645
https://doi.org/10.4269/ajtmh.1998.58.645
Autor:
Brian G. Schuster, Kenneth C. Lasseter, Andris Kaminskis, Mark T. Marino, Emil T. Lin, Ralf P. Brueckner
Publikováno v:
The Journal of Clinical Pharmacology. 38:227-235
This study was conducted to determine the pharmacokinetics and pharmacodynamics of pyridostigmine given as 30 mg of pyridostigmine bromide every 8 hours in healthy subjects. Plasma pyridostigmine concentration and red blood cell acetylcholinesterase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526544fa6eaef6dca5091d96486c2718
https://doi.org/10.1002/j.1552-4604.1998.tb04420.x
https://doi.org/10.1002/j.1552-4604.1998.tb04420.x
Publikováno v:
Spine. 21:2363-2367
Study Design. This study is a prospective, controlled study of the effect of intraoperative and postoperative blood loss during spinal surgery on serum cefazolin level. Objectives. To determine what effect, if any, intraoperative blood loss has on se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b288d0b38a4178aedd4031714a22724
https://doi.org/10.1097/00007632-199610150-00011
https://doi.org/10.1097/00007632-199610150-00011
Publikováno v:
Pharmaceutical Research. :1505-1510
Methemoglobin (MHb) formation can be a clinically significant and dose-limiting side effect of 8-aminoquinoline antimalarials. MHb may also protect against cyanide poisoning. A two-compartment pharmacokinetic model, linked to a sigmoid Emax pharmacod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a1261d0c34e0961c7d2af63e3d49036
https://doi.org/10.1023/a:1015842316177
https://doi.org/10.1023/a:1015842316177
Autor:
Ralf P. Brueckner, Jeffrey J. Meter, Joachim J. Tenuta, William Hopkinson, David W. Polly, Lynn M. Asplund
Publikováno v:
The Journal of bone and joint surgery. American volume. 78(8)
The effect of intraoperative blood loss on serum levels of cefazolin in patients being managed with total hip arthroplasty was studied. Eighteen patients, thirteen men and five women, with a mean age of sixty-five years (range, forty to eighty-five y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df0a529ed9b22792d07e3eb91376653
https://pubmed.ncbi.nlm.nih.gov/8753712
https://pubmed.ncbi.nlm.nih.gov/8753712
Autor:
Trinka S. Coster, Moshe J. Shmuklarsky, Brian G. Schuster, Ralf P. Brueckner, David L. Wesche
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:1293-1294
The prophylactic efficacy of WR 238605, a primaquine analog, was studied with a human Plasmodium falciparum challenge model. A single oral dose of 600 mg, administered 1 day prior to challenge, successfully protected three of four subjects. The fourt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ab0d883613be97a18dbd490db73b86
https://doi.org/10.1128/aac.42.5.1293
https://doi.org/10.1128/aac.42.5.1293
Autor:
Ralf P Brueckner, Barbara Guller
Publikováno v:
Computers and Biomedical Research. 20:99-103
Right ventricular hypertrophy (RVH) is the most frequent abnormality in children with heart disease. We have developed a computer electrocardiogram (ECG) diagnosis program to evaluate new scaler electrocardiographic criteria for the diagnosis of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f324cf271f3c001a47a4b516523f0b5f
https://doi.org/10.1016/0010-4809(87)90022-x
https://doi.org/10.1016/0010-4809(87)90022-x