Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ralf Lutterbüse"'
Autor:
Eva Krinner, Patrick Hoffmann, Peter Kufer, Bernd Schlereth, Patrick A. Baeuerle, Klaus Brischwein, Cornelia Haas, Ralf Lutterbüse
Publikováno v:
Immunobiology. 214:441-453
MT110 is an EpCAM/CD3-bispecific antibody construct in clinical development for the treatment of patients with adenocarcinoma expressing EpCAM (CD326). Like other members of this antibody class, MT110 can engage resting, polyclonal CD8(+) and CD4(+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c076f716056179cb254b0ba27e4ec23
https://doi.org/10.1016/j.imbio.2008.11.014
https://doi.org/10.1016/j.imbio.2008.11.014
Autor:
Antonio J. da Silva, Petra Kleindienst, Roman Kischel, Sandra Lippold, Klaus Brischwein, Iduna Fichtner, Patrick A. Baeuerle, Bernd Schlereth, Mathias Locher, Ralf Lutterbüse, Grit Lorenczewski, Peter Kufer
Publikováno v:
Cancer Immunology, Immunotherapy. 55:785-796
Bispecific single-chain antibody constructs specific for human CD3 have been extensively studied for antitumor activity in human xenograft models using severe combined immunodeficient mice supplemented with human T cells. High efficacy at low effecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277bb1e20144892a1594bd75c1d227fe
https://doi.org/10.1007/s00262-005-0082-x
https://doi.org/10.1007/s00262-005-0082-x
Autor:
Annegret de Baey, Peter Kufer, Ines Mende, Andreas Wolf, Eugen Kopp, Patrick Hoffmann, Ralf Lutterbüse, Patrick A. Baeuerle
Publikováno v:
International Immunology. 17:539-547
Conjugates of peptide antigens with antibodies specifically recognizing surface molecules on dendritic cells (DC) represent an attractive approach to target antigens to antigen-presenting cells (APC) for the induction of specific T cell responses. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee160be6715b265977db3198f125786f
https://doi.org/10.1093/intimm/dxh232
https://doi.org/10.1093/intimm/dxh232
Autor:
Grit Lorenczewski, Michael Grün, Bernd Schlereth, Ralf C. Bargou, Iduna Fichtner, Per Gjorstrup, Gert Riethmüller, Patrick A. Baeuerle, Torsten Dreier, Ralf Lutterbüse, Peter Kufer
Publikováno v:
The Journal of Immunology. 170:4397-4402
We have recently demonstrated that a recombinant single-chain bispecific Ab construct, bscCD19xCD3, in vitro induces rapid B lymphoma-directed cytotoxicity at picomolar concentrations with unstimulated peripheral T cells. In this study, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8650a3a54224ea83b63267a1c2448b06
https://doi.org/10.4049/jimmunol.170.8.4397
https://doi.org/10.4049/jimmunol.170.8.4397
Publikováno v:
Discovery medicine. 4(23)
Extract: While monoclonal antibodies closely resemble the naturally occurring immune defense proteins, bispecific antibodies (i.e., antibodies detecting two different antigens) are not found in nature. Both types of antibodies share the feature of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23be0987cd6c1a3b6e6f2d7fd5646933
https://pubmed.ncbi.nlm.nih.gov/20704969
https://pubmed.ncbi.nlm.nih.gov/20704969
Publikováno v:
Trends in biotechnology. 22(5)
Bispecific antibodies usually do not occur in nature but are constructed by recombinant DNA or cell-fusion technologies. Most are designed to recruit cytotoxic effector cells of the immune system effectively against pathogenic target cells. This comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3002d719d7a2df1b8f8a2aba8487845a
https://pubmed.ncbi.nlm.nih.gov/15109810
https://pubmed.ncbi.nlm.nih.gov/15109810
Publikováno v:
Current opinion in molecular therapeutics. 5(4)
Single-chain bispecific antibodies are emerging as an extremely powerful and promising class of polyclonal T-cell-engaging proteins with hitherto unknown properties. Such bispecific antibodies have the potential to bypass most T-cell escape mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c70fcc5545742bf9a0e9d692e73f1edd
https://pubmed.ncbi.nlm.nih.gov/14513685
https://pubmed.ncbi.nlm.nih.gov/14513685
Autor:
Peter, Kufer, Alfred, Zippelius, Ralf, Lutterbüse, Ingo, Mecklenburg, Thomas, Enzmann, Anthony, Montag, Dorothea, Weckermann, Bernward, Passlick, Nadja, Prang, Peter, Reichardt, Martin, Dugas, Manfred W, Köllermann, Klaus, Pantel, Gert, Riethmüller
Publikováno v:
Cancer research. 62(1)
Systemically disseminated tumor cells have become the subject of intensive research as the presumed seminal precursors of later distant metastasis. We describe here a novel sensitive multimarker nested reverse transcription (RT)-PCR capable of detect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6db37be4ffbddf71c5e92f50692e8253
https://pubmed.ncbi.nlm.nih.gov/11782385
https://pubmed.ncbi.nlm.nih.gov/11782385
Autor:
Peter Kufer, Matthias Klinger, Eugen Leo, Ralf C. Bargou, Ralf Lutterbüse, Petra Kirchinger, Carsten Reinhardt, Patrick Bäuerle
Publikováno v:
Blood. 108:2725-2725
MT103 (MEDI-538) is a bispecific single-chain antibody construct directed at CD3 on human T cells and CD19 on human B lymphoma and normal B cells. Transient linkage of B and T cells by MT103 provides T cells with a T cell receptor (TCR)-like signal l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e955af3f0b256c0aa592a5a2f753d79
https://doi.org/10.1182/blood.v108.11.2725.2725
https://doi.org/10.1182/blood.v108.11.2725.2725