Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Ralf Langen"'
Autor:
Alan K. Okada, Kazuki Teranishi, Mark R. Ambroso, Jose Mario Isas, Elena Vazquez-Sarandeses, Joo-Yeun Lee, Arthur Alves Melo, Priyatama Pandey, Daniel Merken, Leona Berndt, Michael Lammers, Oliver Daumke, Karen Chang, Ian S. Haworth, Ralf Langen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lysine acetylation regulates the function of soluble proteins in vivo, yet it remains largely unexplored whether lysine acetylation regulates the function of membrane proteins. Here, the authors map lysine acetylation predominantly in membrane-intera
Externí odkaz:
https://doaj.org/article/969a6247f4f548d799fa269799855a27
Autor:
J. Mario Isas, Nitin K. Pandey, Hui Xu, Kazuki Teranishi, Alan K. Okada, Ellisa K. Fultz, Anoop Rawat, Anise Applebaum, Franziska Meier, Jeannie Chen, Ralf Langen, Ansgar B. Siemer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Huntingtin exon-1 (HTTex1) consists of a N-terminal N17 domain, the disease causing polyQ domain and a C-terminal proline-rich domain (PRD). Here, the authors combine electron paramagnetic resonance (EPR), solid-state NMR with other biophysical metho
Externí odkaz:
https://doaj.org/article/a3ad6629dcdc4912b80f4ba73af97d8a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3484 (2023)
The enamel matrix protein Ameloblastin (Ambn) has critical physiological functions, including regulation of mineral formation, cell differentiation, and cell–matrix adhesion. We investigated localized structural changes in Ambn during its interacti
Externí odkaz:
https://doaj.org/article/fd280f61b864414990ae64f615570a51
Autor:
Anjalika Chongtham, J. Mario Isas, Nitin K. Pandey, Anoop Rawat, Jung Hyun Yoo, Tara Mastro, Mary B. Kennedy, Ralf Langen, Ali Khoshnan
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105517- (2021)
Huntington’s disease (HD) is a genetically inherited neurodegenerative disorder caused by expansion of a polyglutamine (polyQ) repeat in the exon-1 of huntingtin protein (HTT). The expanded polyQ enhances the amyloidogenic propensity of HTT exon 1
Externí odkaz:
https://doaj.org/article/b14f1f67bf2e4d5bac793d3277f76d60
Autor:
Julia R. Taylor, Daniel J. Fernandez, Shantaé M. Thornton, Joseph G. Skeate, Kim P. Lühen, Diane M. Da Silva, Ralf Langen, W. Martin Kast
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Human papillomavirus (HPV) entry into epithelial cells is independent of canonical endocytic pathways. Upon interaction with host cells, HPV establishes infection by traversing through an endocytic pathway that is clathrin- and caveolin-inde
Externí odkaz:
https://doaj.org/article/97141fe03bcf420b9794b641585f6e8a
Autor:
Alan K. Okada, Kazuki Teranishi, Fleur Lobo, J. Mario Isas, Jialin Xiao, Kelvin Yen, Pinchas Cohen, Ralf Langen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Mitochondrial-derived peptides (MDPs) and their analogs have emerged as wide-spectrum, stress response factors protective in amyloid disease models. MDP cytoprotective functions are generally attributed to anti-apoptotic activity, however, l
Externí odkaz:
https://doaj.org/article/0f99bdda07fa499097deb4fdc1230f9a
Autor:
Jobin Varkey, Jiantao Zhang, Junghyun Kim, Gincy George, Guijuan He, George Belov, Ralf Langen, Xiaofeng Wang
Publikováno v:
Viruses, Vol 12, Iss 12, p 1466 (2020)
Positive-strand RNA viruses universally remodel host intracellular membranes to form membrane-bound viral replication complexes, where viral offspring RNAs are synthesized. In the majority of cases, viral replication proteins are targeted to and play
Externí odkaz:
https://doaj.org/article/99e49b746c814a63ac026382659bc07a
Autor:
Valentina Fodale, Natalie C Kegulian, Margherita Verani, Cristina Cariulo, Lucia Azzollini, Lara Petricca, Manuel Daldin, Roberto Boggio, Alessandro Padova, Rainer Kuhn, Robert Pacifici, Douglas Macdonald, Ryan C Schoenfeld, Hyunsun Park, J Mario Isas, Ralf Langen, Andreas Weiss, Andrea Caricasole
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e112262 (2014)
BACKGROUND:In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display a high propensity to misfold and aggregat
Externí odkaz:
https://doaj.org/article/4a6d9360eb37452db5d79a45e783c38e
Autor:
Andrew W Woodham, Diane M Da Silva, Joseph G Skeate, Adam B Raff, Mark R Ambroso, Heike E Brand, J Mario Isas, Ralf Langen, W Martin Kast
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43519 (2012)
Mucosotropic, high-risk human papillomaviruses (HPV) are sexually transmitted viruses that are causally associated with the development of cervical cancer. The most common high-risk genotype, HPV16, is an obligatory intracellular virus that must gain
Externí odkaz:
https://doaj.org/article/a95a282ebc4a4c70b78031dcbef4845a
Autor:
Leona Berndt, Elena Vazquez-Sarandeses, Arthur Alves de Melo, Kazuki Teranishi, Ralf Langen, Mark R. Ambroso, Michael Lammers, Daniel Merken, Oliver Daumke, Ian S. Haworth, Joo-Yeun Lee, Alan K Okada, Jose Mario Isas, Karen Chang, Priyatama Pandey
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Lysine acetylation regulates the function of soluble proteins in vivo, yet it remains largely unexplored whether lysine acetylation regulates membrane protein function. Here, we use bioinformatics, biophysical analysis of recombinant proteins, live-c