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pro vyhledávání: '"Ralf Kubitz"'
One major function of the liver is the uptake of endo- and xenobiotics from the bloodstream and their excretion into bile. The transport systems involved in hepatobiliary transport have been recently cloned and characterized at the molecular level an
Autor:
Elisabeth Lang, Vitaly I. Pozdeev, Sergios Gatidis, Syed M. Qadri, Dieter Häussinger, Ralf Kubitz, Diran Herebian, Ertan Mayatepek, Florian Lang, Karl S. Lang, Philipp A. Lang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 4, Pp 1500-1509 (2016)
Background/Aims: In nucleated cells, bile acids may activate cation channels subsequently leading to entry of Ca2+. In erythrocytes, increase of cytosolic Ca2+ activity triggers eryptosis, the suicidal death of erythrocytes characterized by phosphati
Externí odkaz:
https://doaj.org/article/21cfc1dff59a4aa8b57a3f6c6dfd1941
Autor:
Nadja Lehwald, Constanze Duhme, Iryna Pinchuk, Julian Kirchner, Kristina Wieferich, Moritz Schmelzle, Kerstin Jurk, Beatrice A. Windmöller, Wolfgang Hübner, Bernhard Homey, Johannes Bode, Ralf Kubitz, Tahar Benhidjeb, Martin Krüger, Simon C. Robson, Wolfram T. Knoefel, Beate E. Kehrel, Jan Schulte am Esch
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6431 (2020)
We previously demonstrated that clinical administration of mobilized CD133+ bone marrow stem cells (BMSC) accelerates hepatic regeneration. Here, we investigated the potential of platelets to modulate CD133+BMSC homing to hepatic endothelial cells an
Externí odkaz:
https://doaj.org/article/6d7e5492f3ba413cbbd900af521214d9
Autor:
Ralf Kubitz
Publikováno v:
Gastro-News. 8:44-47
Autor:
Ralf Kubitz, Dieter Häussinger, Ertan Mayatepek, Christoph G. W. Gertzen, Diran Herebian, Holger Gohlke, Verena Keitel, Lutz Schmitt
Publikováno v:
Biological chemistry 402(9), 1047-1062 (2021). doi:10.1515/hsz-2021-0156
Bile acids perform vital functions in the human liver and are the essential component of bile. It is therefore not surprising that the biology of bile acids is extremely complex, regulated on different levels, and involves soluble and membrane recept
Autor:
Dieter Häussinger, Ralf Kubitz
Publikováno v:
Neues aus Wissenschaft und Lehre der Heinrich-Heine-Universität Düsseldorf 2010 ISBN: 9783110720051
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b303fe5bf434f50201bb2215b8c6f104
https://doi.org/10.1515/9783110720051-048
https://doi.org/10.1515/9783110720051-048
Autor:
Frank Leinen, Stefanie Ritz-Timme, Raimund Schirmeister, Andreas Hippe, Johannes Dietlein, Jan Schulte am Esch, Gerhard Schurz, Volker Weuthen, Ricarda Bauschke-Hartung, Ulrike Brunenberg-Piel, Timm Oliver Goecke, Ulrich Koppitz, Hans-Theo Normann, Hans Werner Müller, Roland Fenk, Esther Betz, Guido Kobbe, Peter Westhoff, Alfons Hugger, Peter Albers, Artur Lichtenberg, Bernd Günter, Johannes Siegrist, Vlada B. Urlacher, Michale Feldbrügge, Sigrun Wegener-Feldbrügge, Wolfgang Janni, Holger Gohlke, Timo van Treeck, Ulrich Decking, Helmut Frister, Wilfried Budach, Gero Maatz, Beate Fieseler, Peter Feindt, Susanne Brandt, Felix B. Hüsken, Andreas Weber, Ralph Alexander Lorz, Justus Haucap, Michael Beurskens, Hartwig Hummel, Peter Sass, Helmut E. Gabbert, Nadine Müller, Gabriele Gloger-Tippelt, Susanne Leitner, Andreas Feuerborn, Merja Mahrt, Stefan Süss, Cornelius Puschmann, Norbert Gattermann, Othmar Kalthoff, Alexander Tokar, Sabine Etges, H. Michael Piper, Ulrich Germing, Frank Meyer, Jens Sagemüller, Katrin Weller, Heike Brötz-Oesterhelt, Joachim Windolf, Thorsten Halling, Christian Ohmann, Brigitte Royer-Pokora, Christian Dumpitak, Dieter Häussinger, Axel Gödecke, Rüdiger Hahn, Rolf Willhardt, Christel Marian, Andrea Icks, Anja Müller-Homey, Rainer Haas, Evelyn Vollmeister, Cord Eberspächer, Helmut Ritter, Reinhard Pietrowsky, Wolfram Trudo Knoefel, Matthias Schneider, Stephan Roth, Jörg Vögele, Katja Koschorreck, Thomas Beikler, Sascha Flohé, Monir Tabatabai, Peter Indefrey, Andreas P. M. Weber, Christoph Ingenhoven, Susanne Keuneke, Stefan Schweizer, Susanne Schillberg, Matthias Schott, Shingo Shimada, Ralf Kubitz, Andreas Erhardt, Stefanie Knöll, Dirk Olzen, Rüdiger Simon, Philipp Alexander Lang, Elisabeth Stratmann, Ursula Kessen, Bernhard Homey, Isabella Peters, Christian Kersting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008a8863aed9bc5eb3397e2991e3cb3d
https://doi.org/10.1515/9783110720051
https://doi.org/10.1515/9783110720051
Autor:
Jan Stindt, Philipp Ellinger, Claudia Stross, Verena Keitel, Dieter Häussinger, Sander H J Smits, Ralf Kubitz, Lutz Schmitt
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20562 (2011)
Homologous recombination in Saccharomyces cerevisiae is a well-studied process. Here, we describe a yeast-recombination-based approach to construct and mutate plasmids containing the cDNA of the human bile salt export pump (BSEP) that has been shown
Externí odkaz:
https://doaj.org/article/bdcdee7e959f46709a3483635d6b4003
Autor:
John Hicks, Sanjiv Harpavat, Mihail Firan, Verena Keitel, Milton J. Finegold, Ralf Kubitz, Kalyani R. Patel, Hao Wu, Karen W. Eldin
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 65:364-369
Recurrent bile salt export pump (rBSEP) disease has been reported in progressive familial intrahepatic cholestasis type 2 (PFIC2) patients following liver transplantation (LT) and is often refractory to standard anti-cellular rejection immunosuppress
Autor:
Carola Dröge, Ralf Kubitz, Jan Stindt, Ulrike Teufel, Daniel Wenning, Guido Engelmann, Dieter Häussinger, Stefanie Kluge, Claudia Stross, Christa Flechtenmacher, Claus Peter Schmitt
Publikováno v:
Pediatric Transplantation. 20:987-993
PFIC due to BSEP mutations (PFIC type 2) often necessitates OLT. It has recently been recognized that some PFIC-2 patients develop phenotypic disease recurrence post-OLT due to the appearance of anti-BSEP antibodies. Here, we describe a boy who becam