Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Ralf Jockers"'
Autor:
Ralf Jockers, Oreste Gualillo
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/c58b702cc18f4c1ba032c67727c6d9e2
Autor:
Bertrand Duvillié, Ralf Jockers
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/c9e9157a553a4bcea53edcffd787284d
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/3af6023161a14783afae34cd1bcca558
Autor:
Erika Cecon, Atsuro Oishi, Marine Luka, Delphine Ndiaye-Lobry, Arnaud François, Mathias Lescuyer, Fany Panayi, Julie Dam, Patricia Machado, Ralf Jockers
Publikováno v:
eLife, Vol 12 (2023)
Aggregates of the tau protein are a well-known hallmark of several neurodegenerative diseases, collectively referred to as tauopathies, including frontal temporal dementia and Alzheimer’s disease (AD). Monitoring the transformation process of tau f
Externí odkaz:
https://doaj.org/article/60b46b54a6b242a9afabff8b315dade9
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13927 (2023)
Simufilam is a novel oral drug candidate in Phase 3 clinical trials for Alzheimer’s disease (AD) dementia. This small molecule binds an altered form of filamin A (FLNA) that occurs in AD. This drug action disrupts FLNA’s aberrant linkage to the
Externí odkaz:
https://doaj.org/article/ab956b87a59c4e17a31e3090a28cc4bf
Autor:
Ines S Amorim, Sylvie Challal, Laetitia Cistarelli, Thierry Dorval, Laurene Abjean, Manuelle Touzard, Nicolas Arbez, Arnaud François, Fany Panayi, Ross Jeggo, Erika Cecon, Atsuro Oishi, Julie Dam, Ralf Jockers, Patricia Machado
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283941 (2023)
Intracellular accumulation of tau protein is a hallmark of Alzheimer's Disease and Progressive Supranuclear Palsy, as well as other neurodegenerative disorders collectively known as tauopathies. Despite our increasing understanding of the mechanisms
Externí odkaz:
https://doaj.org/article/8015c54627e64350a7b3b92db676e019
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/1b5e9178245a4c6eb3e2e204a6e053ab
Autor:
Nedjma Labani, Florence Gbahou, Marc Noblet, Bernard Masri, Olivier Broussaud, Jianfeng Liu, Ralf Jockers
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1845 (2023)
Melatonin is a tryptophan derivative synthesized in plants and animals. In humans, melatonin acts on melatonin MT1 and MT2 receptors belonging to the G protein-coupled receptor (GPCR) family. Synthetic melatonin receptor agonists are prescribed for i
Externí odkaz:
https://doaj.org/article/79a981ecc07d4f81b4efc193ea0f6ac0
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101024- (2022)
Summary: The SARS-CoV-2 coronavirus infects human cells through the interaction of the viral envelope spike protein (IPR044366) with the human angiotensin-converting enzyme 2 (ACE2), expressed at the surface of target cells. Here, we describe a detai
Externí odkaz:
https://doaj.org/article/62e5fa1e7a7b49bc91579994e85ff7b9
Autor:
Arini Isnani Preninka, Karen Kuriya, Kyosuke Yazawa, Michiko Yoshii, Yuhki Yanase, Ralf Jockers, Julie Dam, Toru Hosoi, Koichiro Ozawa
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Abnormally high serum homocysteine levels have been associated with several disorders, including obesity, cardiovascular diseases or neurological diseases. Leptin is an anti-obesity protein and its action is mainly mediated by the activation of its O
Externí odkaz:
https://doaj.org/article/2fbd4a84bb824dbe952a9169e3ce8c2e