Výsledky vyhledávání - "Ralf J. Rieker"

Akademický článek

Neutrophil extracellular traps characterize caseating granulomas

Publikováno v: Cell Death and Disease, Vol 15, Iss 7, Pp 1-12 (2024)

Abstract Tuberculosis (TB) remains one of the top 10 causes of death worldwide and still poses a serious challenge to public health. Recent attention to neutrophils has uncovered unexplored areas demanding further investigation. Therefore, the aim of

Externí odkaz: https://doaj.org/article/eea18bd40a674ab488cd864665af2707

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Akademický článek

Fiber rich food suppressed airway inflammation, GATA3 + Th2 cells, and FcεRIα+ eosinophils in asthma

Autor: Alicia Schenzel, Adriana Geiger, Elvedina Nendel, Zuqin Yang, Susanne Krammer, Anna Leberle, Ann-Kathrin Brunst, Sonja Trump, Susanne Mittler, Manfred Rauh, Carol I. Geppert, Patrick Tausche, Katja Hohenberger, Ralf J. Rieker, Oliver Schieweck, Sebastian Zundler, Susetta Finotto

Publikováno v: Frontiers in Nutrition, Vol 11 (2024)

BackgroundAllergic Asthma is a disease presenting various endotypes and no current therapies act curative but alleviate disease symptoms. Dietary interventions are gaining increasing importance in regulating immune responses. Furthermore, short chain

Externí odkaz: https://doaj.org/article/39b0a87bb91247229f8164f0537f2605

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Akademický článek

Contribution of serum lipids and cholesterol cellular metabolism in lung cancer development and progression

Autor: Philipp Hartmann, Denis I. Trufa, Katja Hohenberger, Patrick Tausche, Sonja Trump, Susanne Mittler, Carol I. Geppert, Ralf J. Rieker, Oliver Schieweck, Horia Sirbu, Arndt Hartmann, Susetta Finotto

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Neoplasms of the lungs are the leading cause of cancer incidence and mortality worldwide. Although immunotherapy has increased the overall survival of patients with lung cancer, there is the need to improve this treatment. At this regard, bl

Externí odkaz: https://doaj.org/article/8208be4c350044d98812e834b5d8bad4

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Akademický článek

Vitamin D3 resolved human and experimental asthma via B lymphocyte–induced maturation protein 1 in T cells and innate lymphoid cells

Autor: Janina C. Grund, Susanne Krammer, RPh, Zuqin Yang, MSc, Hannah Mitländer, Manfred Rauh, PhD, Sabine Zirlik, MD, Alexander Kiefer, MD, Theodor Zimmermann, MD, Ralf J. Rieker, MD, Carol I. Geppert, MD, Nikolaos G. Papadopoulos, MD, Susetta Finotto, PhD

Publikováno v: Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 3, Pp 100099- (2023)

Background: Vitamin D3 (VitD3) is known to have immunomodulatory functions, and VitD3 deficiency is associated with more severe asthma. Objective: We aimed to assess the immunoregulatory effects of VitD3 food supplementation on asthma manifestation,

Externí odkaz: https://doaj.org/article/c7ef54dabe87475d9e5fdaca89eb3997

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Akademický článek

Targeted deletion of Interleukin-3 results in asthma exacerbations

Autor: Julia Kölle, Theodor Zimmermann, Alexander Kiefer, Ralf J. Rieker, Paraskevi Xepapadaki, Sebastian Zundler, Nikolaos G. Papadopoulos, Susetta Finotto

Publikováno v: iScience, Vol 25, Iss 6, Pp 104440- (2022)

Summary: The cytokine interleukin-3 (IL-3) acts on early hematopoietic precursor cells. In humans, Treg cells secrete IL-3 and repress inflammatory cells except for basophils. The present study aims to elucidate the contribution of IL-3 in the develo

Externí odkaz: https://doaj.org/article/b332aab80fca4b019218138090718865

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Akademický článek

IL-9 Producing Tumor-Infiltrating Lymphocytes and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer

Autor: Lisanne Heim, Zuqin Yang, Patrick Tausche, Katja Hohenberger, Mircea T. Chiriac, Julia Koelle, Carol-Immanuel Geppert, Katerina Kachler, Sarah Miksch, Anna Graser, Juliane Friedrich, Rakshin Kharwadkar, Ralf J. Rieker, Denis I. Trufa, Horia Sirbu, Markus F. Neurath, Mark H. Kaplan, Susetta Finotto

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Although lung cancer is the leading cause of cancer deaths worldwide, the mechanisms how lung cancer cells evade the immune system remain incompletely understood. Here, we discovered IL-9-dependent signaling mechanisms that drive immune evasion in no

Externí odkaz: https://doaj.org/article/123c1359ce714a9b810a0f1bd63a872f

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Akademický článek

Glucose-Restricted Diet Regulates the Tumor Immune Microenvironment and Prevents Tumor Growth in Lung Adenocarcinoma

Autor: Alexander Gähler, Denis I. Trufa, Mircea T. Chiriac, Patrick Tausche, Katja Hohenberger, Ann-Kathrin Brunst, Manfred Rauh, Carol I. Geppert, Ralf J. Rieker, Susanne Krammer, Anna Leberle, Markus F. Neurath, Horia Sirbu, Arndt Hartmann, Susetta Finotto

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

BackgroundLung cancer is the second common cancer type in western countries and has a high mortality. During the development and progression of the tumor, the nutrients in its environment play a central role. The tumor cells depend crucially on gluco

Externí odkaz: https://doaj.org/article/5af820fb33ba445790484f248af9f25f

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Akademický článek

Vascular occlusion by neutrophil extracellular traps in COVID-19

Publikováno v: EBioMedicine, Vol 58, Iss , Pp 102925- (2020)

Background: Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. Methods: Samples

Externí odkaz: https://doaj.org/article/724dc37caf5547c390e6022a21be3717

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