Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ralf Heim"'
Publikováno v:
Journal of Computer-Aided Molecular Design. 25:51-66
A series of 51 5-HT(2A) partial agonistic arylethylamines (primary or benzylamines) from different structural classes (indoles, methoxybenzenes, quinazolinediones) was investigated by fragment regression analysis (FRA), docking and 3D-QSAR approaches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f748d293dbcbb5906100ece254269d7
https://doi.org/10.1007/s10822-010-9400-2
https://doi.org/10.1007/s10822-010-9400-2
Publikováno v:
Zeitschrift für anorganische und allgemeine Chemie. 636:320-324
The twelve membered and eighteen membered cyclosiloxazanes [Me2SiOSiMe2N(H)SiMe2O]2 (3) and [Me2SiOSiMe2N(H)SiMe2O]3 (4) have been obtained as colourless liquids from the reaction of 1,5-Dichlorohexamethyltrisiloxane with ammonia at–50 °C without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62a3fb373cc23be2fed8ce1702a0a78b
https://doi.org/10.1002/zaac.200900366
https://doi.org/10.1002/zaac.200900366
Autor:
Craig M. Williams, Stefan Wiedemann, Paul V. Bernhardt, Brett D. Schwartz, David Tilly, Ralf Heim
Publikováno v:
European Journal of Organic Chemistry. 2006:3181-3192
Studies detailing synthetic approaches to a variety of biosynthetically related vibsanin-type diterpenes (i.e. vibsanin E, 15-O-methylcyclovibsanin B, 3-hydroxy-vibsanin E, furano-vibsanin A, and 3-O-methylfuranovibsanin A) are discussed. Biogenetica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88711261b9280bd76e8681c55d059430
https://doi.org/10.1002/ejoc.200600246
https://doi.org/10.1002/ejoc.200600246
Publikováno v:
Tetrahedron. 61:3771-3779
Specific 3-azabicyclo[3.3.1]nonane derivatives undergo skeletal cleavage when subjected to light or Lewis acidic conditions affording novel heterotricycles, which is in stark contrast to 3-oxabicyclo[3.3.1]nonanes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d963f0149d73e90505e252e757929814
https://doi.org/10.1016/j.tet.2005.02.013
https://doi.org/10.1016/j.tet.2005.02.013
Autor:
Rolf W. Hartmann, Ralf Heim, Cornelia M. Grombein, Sabrina Rau, Qingzhong Hu, Christina Zimmer
Publikováno v:
European journal of medicinal chemistry. 89
1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols and related compounds were synthesized and evaluated for inhibition of aldosterone synthase (CYP11B2), a potential target for cardiovascular diseases associated with elevated plasma aldosterone levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7eeb39d87477084a82034ee21f57e0
https://pubmed.ncbi.nlm.nih.gov/25462268
https://pubmed.ncbi.nlm.nih.gov/25462268
Publikováno v:
ChemInform. 45
1-Arylthio-2-naphthols are obtained as an unexpected result of the nucleophilic aromatic substitution reaction of β-naphthyl triflates with thiophenols.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc931ef7bdf11c60d9c426304187bb54
https://doi.org/10.1002/chin.201412082
https://doi.org/10.1002/chin.201412082
1-(Phenylthio)-3-(pyridin-3-yl)-2-naphthol was obtained as an unexpected result of a nucleophilic aromatic substitution reaction of 3-(pyridine-3-yl)naphthalene-2-yl trifluoromethanesulfonate with thiophenol. This observation led to the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848d5f0376520723b64d4a7ca92c79b5
https://hdl.handle.net/10033/311929
https://hdl.handle.net/10033/311929
Publikováno v:
Journal of medicinal chemistry. 54(7)
Pyridine substituted 3,4-dihydro-1H-quinolin-2-ones (e.g., 1-3) constitute a class of highly potent and selective inhibitors of aldosterone synthase (CYP11B2), a promising target for the treatment of hyperaldosteronism, congestive heart failure, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82930c71732b1e8042afedfdf5507a78
https://pubmed.ncbi.nlm.nih.gov/21384875
https://pubmed.ncbi.nlm.nih.gov/21384875
Publikováno v:
Journal of medicinal chemistry. 51(24)
Pyridine substituted naphthalenes (e.g., I-III) constitute a class of potent inhibitors of aldosterone synthase (CYP11B2). To overcome the unwanted inhibition of the hepatic enzyme CYP1A2, we aimed at reducing the number of aromatic carbons of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f8852c2b9a41edfac80286e3901f98
https://pubmed.ncbi.nlm.nih.gov/19049427
https://pubmed.ncbi.nlm.nih.gov/19049427
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 116(3-5)
Aldosterone plays a crucial role in salt and water homeostasis but in case of pathologically increased plasma aldosterone levels it is also involved in the development and the progression of severe cardiovascular diseases like heart failure and myoca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ec6a1fc02d3be438f3f6db385da2c9
https://pubmed.ncbi.nlm.nih.gov/19427380
https://pubmed.ncbi.nlm.nih.gov/19427380