Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Ralf Ficner"'
Autor:
Ridhima Gomkale, Andreas Linden, Piotr Neumann, Alexander Benjamin Schendzielorz, Stefan Stoldt, Olexandr Dybkov, Markus Kilisch, Christian Schulz, Luis Daniel Cruz-Zaragoza, Blanche Schwappach, Ralf Ficner, Stefan Jakobs, Henning Urlaub, Peter Rehling
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The TOM and TIM23 complexes facilitate the transport of nuclear-encoded proteins into the mitochondrial matrix. Here, the authors use a stalled client protein to purify the translocation supercomplex and gain insight into the TOM-TIM23 interface and
Externí odkaz:
https://doaj.org/article/8744caceb7e7478892fe2e26b0cf2134
Autor:
Larissa Krüger, Christina Herzberg, Dennis Wicke, Heike Bähre, Jana L. Heidemann, Achim Dickmanns, Kerstin Schmitt, Ralf Ficner, Jörg Stülke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
In several bacteria, cyclic di-AMP mediates potassium (K+) and osmotic homeostasis. Here, the authors show that DarB, a Bacillus subtilis protein previously reported to bind cyclic di-AMP, interacts with the (p)ppGpp synthetase/hydrolase Rel in a K+-
Externí odkaz:
https://doaj.org/article/09902e6043b6418cada4e487ae632736
Autor:
Roshan Priyarangana Perera, Alaa Shaikhqasem, Nadia Rostam, Achim Dickmanns, Ralf Ficner, Kai Tittmann, Roland Dosch
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1507 (2021)
Many multicellular organisms specify germ cells during early embryogenesis by the inheritance of ribonucleoprotein (RNP) granules known as germplasm. However, the role of complex interactions of RNP granules during germ cell specification remains elu
Externí odkaz:
https://doaj.org/article/d6eb163b6cc24fed8b2e280df3c08cb9
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The biological function of lipoxygenases depends on the regio and stereo specific formation of fatty acid-derived hydroperoxides and different concepts exist to explain the mechanism that directs dioxygen to a specific carbon atom within the
Externí odkaz:
https://doaj.org/article/984ebb9695be482e9b12126648e01635
Autor:
Edith Bonnin, Pauline Cabochette, Alessandro Filosa, Ramona Jühlen, Shoko Komatsuzaki, Mohammed Hezwani, Achim Dickmanns, Valérie Martinelli, Marjorie Vermeersch, Lynn Supply, Nuno Martins, Laurence Pirenne, Gianina Ravenscroft, Marcus Lombard, Sarah Port, Christiane Spillner, Sandra Janssens, Ellen Roets, Jo Van Dorpe, Martin Lammens, Ralph H Kehlenbach, Ralf Ficner, Nigel G Laing, Katrin Hoffmann, Benoit Vanhollebeke, Birthe Fahrenkrog
Publikováno v:
PLoS Genetics, Vol 14, Iss 12, p e1007845 (2018)
Nucleoporins build the nuclear pore complex (NPC), which, as sole gate for nuclear-cytoplasmic exchange, is of outmost importance for normal cell function. Defects in the process of nucleocytoplasmic transport or in its machinery have been frequently
Externí odkaz:
https://doaj.org/article/88c96d3ae2aa45ddb907f5a735313301
Autor:
Carsten Boesler, Norbert Rigo, Maria M. Anokhina, Marcel J. Tauchert, Dmitry E. Agafonov, Berthold Kastner, Henning Urlaub, Ralf Ficner, Cindy L. Will, Reinhard Lührmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The assembly of the splicesome involves several distinct stages that require the sequential action of DExD/H-box RNA helicases. Here, the authors uncover a new intermediate, the pre-B complex, that accumulates in the presence of an inactive form of t
Externí odkaz:
https://doaj.org/article/e7d1d18e40824533a67b9650add6c83c
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 2, Pp 276-287 (2016)
In eukaryotes, oxidized PUFAs, so-called oxylipins, are vital signaling molecules. The first step in their biosynthesis may be catalyzed by a lipoxygenase (LOX), which forms hydroperoxides by introducing dioxygen into PUFAs. Here we characterized Csp
Externí odkaz:
https://doaj.org/article/7c25cb769ff64cedbbf1e09f3ba864e5
Autor:
Miriam Kolog Gulko, Gabriele Heinrich, Carina Gross, Blagovesta Popova, Oliver Valerius, Piotr Neumann, Ralf Ficner, Gerhard H Braus
Publikováno v:
PLoS Genetics, Vol 14, Iss 2, p e1007141 (2018)
The transition from vegetative growth to multicellular development represents an evolutionary hallmark linked to an oxidative stress signal and controlled protein degradation. We identified the Sem1 proteasome subunit, which connects stress response
Externí odkaz:
https://doaj.org/article/da522216f1e14aba9e5059415287dd2a
Autor:
Sarah A. Port, Thomas Monecke, Achim Dickmanns, Christiane Spillner, Romina Hofele, Henning Urlaub, Ralf Ficner, Ralph H. Kehlenbach
Publikováno v:
Cell Reports, Vol 13, Iss 4, Pp 690-702 (2015)
CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine (FG) repeats of multiple nucleoporins. On the cytoplasmic side of the nuclear pore, CRM1 tig
Externí odkaz:
https://doaj.org/article/b9e3ebdaa4eb4fa9bd017adef6b43a68
Publikováno v:
Cells, Vol 4, Iss 3, Pp 538-568 (2015)
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establishment and maintenance of various cancers. Nucleocytoplasmic transport is highly regulated and coordinated, involving different nuclear transport facto
Externí odkaz:
https://doaj.org/article/f6a4a454e02f4e84b5a0d7c6710c12d5