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Akademický článek

Analysis of 16 studies in nine rodent models does not support the hypothesis that diabetic polyuria is a main reason of urinary bladder enlargement

Autor: Zeynep E. Yesilyurt, Jan Matthes, Edith Hintermann, Tamara R. Castañeda, Ralf Elvert, Jesus H. Beltran-Ornelas, Diana L. Silva-Velasco, Ning Xia, Aimo Kannt, Urs Christen, David Centurión, Huige Li, Andrea Pautz, Ebru Arioglu-Inan, Martin C. Michel

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

The urinary bladder is markedly enlarged in the type 1 diabetes mellitus model of streptozotocin-injected rats, which may contribute to the frequent diabetic uropathy. Much less data exists for models of type 2 diabetes. Diabetic polyuria has been pr

Externí odkaz: https://doaj.org/article/f59087392e074b2ea5f40362b866547a

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Akademický článek

Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice

Autor: Dieter Schmoll, Nicole Ziegler, Benoit Viollet, Marc Foretz, Patrick C. Even, Dalila Azzout‐Marniche, Andreas Nygaard Madsen, Martin Illemann, Karen Mandrup, Michael Feigh, Jörg Czech, Heiner Glombik, Jacob A. Olsen, Wolfgang Hennerici, Klaus Steinmeyer, Ralf Elvert, Tamara R. Castañeda, Aimo Kannt

Publikováno v: Hepatology Communications, Vol 4, Iss 7, Pp 1056-1072 (2020)

The worldwide obesity and type 2 diabetes epidemics have led to an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD covers a spectrum of hepatic pathologies ranging from simple steatosis to nonalcoholic steatohepatitis, characterized by fi

Externí odkaz: https://doaj.org/article/9426e7d8200a4cacaf75487e613184ae

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Akademický článek

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.

Publikováno v: PLoS Genetics, Vol 8, Iss 3, p e1002568 (2012)

Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report t

Externí odkaz: https://doaj.org/article/f523068b28034994bbb17295614b1bd1

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Akademický článek

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9468 (2010)

BACKGROUND: In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. METHODOLOGY/PRINCIPAL FINDINGS: Here we show

Externí odkaz: https://doaj.org/article/2a746982e64d423bb314f9a07839f706

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The Novel Phosphate and Bile Acid Sequestrant Polymer SAR442357 Delays Disease Progression in a Rat Model of Diabetic Nephropathy

Autor: Galina Boldina, Dinesh S. Bangari, Aimo Kannt, Ralf Elvert, Anish Konkar, Cynthia Arbeeny, Tamara R. Castañeda, Kuldeep Singh, Mechthilde Falkenhahn, Thomas Hübschle, María Méndez, Petra Scherer, Corinne Rocher, Pradeep K. Dhal, Ian Davison, Uwe Schwahn, Philip J. Larsen

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 376:190-203

As a gut-restricted, nonabsorbed therapy, polymeric bile acid sequestrants (BAS) play an important role in managing hyperlipidemia and hyperglycemia. Similarly, nonabsorbable sequestrants of dietary phosphate have been used for the management of hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54ceb8c7524aeea0488f514c5289b87
https://doi.org/10.1124/jpet.120.000285

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Urinary bladder enlargement across nine rodent models of diabetes: correlations with glucose and insulin levels

Autor: Ralf Elvert, Diana L. Silva-Velasco, Martin C. Michel, Jesus H. Beltran-Ornelas, Aimo Kannt, Tamara R. Castañeda, Andrea Pautz, Huige Li, Jan Matthes, David Centurión, Zeynep Elif Yesilyurt, Ning Xia, Ebru Arioglu-Inan, Edith Hintermann, Urs Christen

The urinary bladder is markedly enlarged in the type 1 diabetes mellitus model of streptozotocin (STZ)-injected rats, but much less data exist for models of type 2 diabetes (T2DM). Diabetic polyuria has been proposed to explain bladder enlargement. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f68716b1bcf9bef91f49b41a6d87c1a
https://doi.org/10.1101/2021.10.25.465601

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Genetic Nicotinamide N-Methyltransferase (Nnmt) Deficiency in Male Mice Improves Insulin Sensitivity in Diet-Induced Obesity but Does Not Affect Glucose Tolerance

Autor: Ralf Elvert, Maria Brachs, Kerstin Jahn-Hofmann, Sebastian Brachs, Felix Bärenz, Anja Pfenninger, Joachim Spranger, Daniel Margerie, James Polack, Aimo Kannt, Knut Mai

Publikováno v: Diabetes. 68:527-542

Antisense oligonucleotide knockdown (ASO-KD) of nicotinamide N-methyltransferase (NNMT) in high-fat diet (HFD)–fed mice has been reported to reduce weight gain and plasma insulin levels and to improve glucose tolerance. Using NNMT-ASO-KD or NNMT kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39f832a174ac69275e830a769b40f6a4
https://doi.org/10.2337/db18-0780

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