Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Ralf Bützow"'
Autor:
Susanna Nousiainen, Outi Kuismin, Siiri Reinikka, Roosa Manninen, Sara Khamaiseh, Mari Kuivalainen, Anna Terho, Sari Koivurova, Maarit Niinimäki, Kari Salokas, Markku Varjosalo, Anne Ahtikoski, Ralf Bützow, Outi Lindgren, Outi Uimari, Pia Vahteristo
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-10 (2023)
Abstract Background Endometriosis is a common, chronic disease among fertile-aged women. Disease course may be highly invasive, requiring extensive surgery. The etiology of endometriosis remains elusive, though a high level of heritability is well es
Externí odkaz:
https://doaj.org/article/6dacf57f4e0f49a8840d6d3a6215fa94
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Endometrial carcinoma (EC) is one of the most common gynecological cancers in the world. In this work we apply Cox proportional hazards (CPH) and optimal survival tree (OST) algorithms to the retrospective prognostic modeling of disease-spec
Externí odkaz:
https://doaj.org/article/7ecf101a2e9a4dce81939468cfe4ed85
Autor:
Miika Mehine, Terhi Ahvenainen, Sara Khamaiseh, Jouni Härkönen, Siiri Reinikka, Tuomas Heikkinen, Anna Äyräväinen, Päivi Pakarinen, Päivi Härkki, Annukka Pasanen, Anna-Liisa Levonen, Ralf Bützow, Pia Vahteristo
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-10 (2022)
Abstract Uterine leiomyomas, or fibroids, are the most common tumors in women of reproductive age. Uterine leiomyomas can be classified into at least three main molecular subtypes according to mutations affecting MED12, HMGA2, or FH. FH-deficient lei
Externí odkaz:
https://doaj.org/article/199d3f3126b54a4fbad0c263ac974ff4
Autor:
Heli Kuisma, Simona Bramante, Kristiina Rajamäki, Lauri J. Sipilä, Eevi Kaasinen, Jaana Kaukomaa, Kimmo Palin, Netta Mäkinen, Jari Sjöberg, Nanna Sarvilinna, Jussi Taipale, Liisa Kauppi, Manuela Tumiati, Antti Hassinen, Janne Pitkäniemi, Jyrki Jalkanen, Sanna Heikkinen, Annukka Pasanen, Oskari Heikinheimo, Ralf Bützow, Niko Välimäki, Lauri A. Aaltonen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Many factors have been associated with chromosomal damage, including mechanical forces in a constrained cellular environment. Here the authors reveal an association between parity and chromosomal damage by analysing karyotypes of 1946 uterine leiomyo
Externí odkaz:
https://doaj.org/article/d2e867958c8a4229a73872634dd5e339
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 1034-1042 (2021)
Abstract Background Mismatch repair (MMR) system has been implicated in the response of mammalian cells to ionizing radiation and DNA damaging agents. We investigated the value of the MMR system in predicting response to adjuvant therapy in endometri
Externí odkaz:
https://doaj.org/article/dbd01a947abd43b590f468a9d2626ffe
Autor:
Astrid Murumägi, Daniela Ungureanu, Mariliina Arjama, Ralf Bützow, Jouko Lohi, Hannu Sariola, Jukka Kanerva, Minna Koskenvuo, Olli Kallioniemi
Publikováno v:
Translational Oncology, Vol 14, Iss 4, Pp 101027- (2021)
Genetic rearrangements involving the anaplastic lymphoma kinase (ALK) gene create oncogenic drivers for several cancers, including malignant peritoneal mesothelioma (MPeM). Here, we report genomic and functional precision oncology profiling on a rare
Externí odkaz:
https://doaj.org/article/333af32b89cc40249fd01611041baefc
Autor:
Annukka Pasanen, Mikko Loukovaara, Elina Kaikkonen, Alisa Olkinuora, Kirsi Pylvänäinen, Pia Alhopuro, Päivi Peltomäki, Jukka-Pekka Mecklin, Ralf Bützow
Publikováno v:
Cancers, Vol 14, Iss 5, p 1348 (2022)
International guidelines recommend universal screening of endometrial carcinoma (EC) patients for Lynch syndrome (LS). This screening is generally based on mismatch repair (MMR) protein immunohistochemistry followed by MLH1 methylation analysis of ML
Externí odkaz:
https://doaj.org/article/2d377a0bba524ab9a48ae3de67e863e0
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0253472 (2021)
ObjectiveTo assess whether the prognostic impact of conventional risk factors and ancillary biomarkers differs across the 2 largest ProMisE molecular subgroups of endometrial carcinoma (EC).MethodsDirect sequencing of POLE exonuclease domain hot spot
Externí odkaz:
https://doaj.org/article/d71ddb2b73cd4825865a760f909702f2
Publikováno v:
Cancers, Vol 14, Iss 3, p 651 (2022)
This was a retrospective study of 604 patients with endometrial carcinoma, classified into ESGO-ESTRO-ESP 2021 clinicopathologic and molecular integrated risk groups. The Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) and Leiden
Externí odkaz:
https://doaj.org/article/cf04e4e041654266a72c78fbcec5d54b
Autor:
Anne Kolehmainen, Annukka Pasanen, Taru Tuomi, Riitta Koivisto-Korander, Ralf Bützow, Mikko Loukovaara
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242733 (2020)
BackgroundClinical factors may influence endometrial cancer survival outcomes. We examined the prognostic significance of age, body mass index (BMI), and type 2 diabetes among molecular subgroups of endometrial cancer.MethodsThis was a single institu
Externí odkaz:
https://doaj.org/article/0daeac62f9b14433ab15a36be613c748