Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ralf Brundiers"'
Autor:
David Klatzmann, Birgitta M. Wöhrl, Laurence Loubiere, Ralf Brundiers, Manfred Konrad, Roger S. Goody
Publikováno v:
ResearcherID
The triphosphorylated form of the nucleoside analogue AZT (AZTTP) acts as a chain terminator during reverse transcription of the human immunodeficiency virus (HIV) genome. The bottleneck in the conversion of AZT to AZTTP is the phosphorylation of AZT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbbd165af01fd9d87e8dc45ddea6df5
https://doi.org/10.1099/vir.0.80529-0
https://doi.org/10.1099/vir.0.80529-0
Autor:
Arnon Lavie, Ilme Schlichting, Ralf Brundiers, Nils Ostermann, Thomas Veit, Manfred Konrad, Roger S. Goody, Jochen Reinstein
Publikováno v:
Structure
Background: Thymidylate kinase (TMPK) is a nucleoside monophosphate kinase that catalyzes the reversible phosphoryltransfer between ATP and TMP to yield ADP and TDP. In addition to its vital role in supplying precursors for DNA synthesis, human TMPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e3fa8b4137d842bb958d9a108a5a8d
https://doi.org/10.1016/s0969-2126(00)00149-0
https://doi.org/10.1016/s0969-2126(00)00149-0
Autor:
Ralf Brundiers, Achim Knappik
Publikováno v:
Springer Protocols Handbooks ISBN: 9781603274746
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7357d5bd2f8f0f49d317b0198f2a4fd0
https://doi.org/10.1007/978-1-59745-198-7_203
https://doi.org/10.1007/978-1-59745-198-7_203
Autor:
John P. Carulli, Ralf Brundiers, Beate Diefenbach, Chao Sun, Alex Lukashin, Daniel R. Kilburn, Thomas Crowell, Humphrey Gardner
Publikováno v:
Genomics. 82(2)
A novel immunoglobulin superfamily (Igsf) protein gene was discovered by computational analysis of human draft genomic DNA, and multiple cDNA clones were obtained. The protein encoded by this gene contains five Ig domains, one transmembrane domain, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7bfa2f0f39b7ac2a40158b664d567c
https://pubmed.ncbi.nlm.nih.gov/12837264
https://pubmed.ncbi.nlm.nih.gov/12837264
Autor:
Thomas Veit, Jochen Reinstein, Ilme Schlichting, Nils Ostermann, Arnon Lavie, Manfred Konrad, Roger S. Goody, Ralf Brundiers
Publikováno v:
The Journal of Biological Chemistry
Based on the knowledge of the crystal structures of yeast and Escherichia coli thymidylate kinases (TmpKs) and the observation that TmpK from E. coli can phosphorylate azidothymidine monophosphate (AZT-MP) much more efficiently than either the yeast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7428af84dc5f31ad9f2ee73f22aad8c6
https://hdl.handle.net/11858/00-001M-0000-002C-2264-111858/00-001M-0000-002C-2262-5
https://hdl.handle.net/11858/00-001M-0000-002C-2264-111858/00-001M-0000-002C-2262-5
Autor:
Manfred Konrad, Nils Ostermann, Roger S. Goody, Ilme Schlichting, Ralf Brundiers, Jochen Reinstein, Arnon Lavie
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The crystal structures of Escherichia coli thymidylate kinase (TmpK) in complex with P 1 -(5′-adenosyl)- P 5 -(5′-thymidyl)pentaphosphate and P 1 -(5′-adenosyl)P 5 -[5′-(3′-azido-3′-deoxythymidine)] pentaphosphate have been solved to 2.0-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a6b12f5c35e0041faa550127c37481
https://pubmed.ncbi.nlm.nih.gov/9826650
https://pubmed.ncbi.nlm.nih.gov/9826650
Autor:
Ilme Schlichting, Jochen Reinstein, Arnon Lavie, Manfred Konrad, Roger S. Goody, Ralf Brundiers
Publikováno v:
Biochemistry
The crystal structure of yeast thymidylate kinase (TmpK) complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) was determined at 2.0 A resolution. In this complex, TmpK adopts a closed conformation with a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef09598cac4b97330b2c1099b9bd74d2
https://pubmed.ncbi.nlm.nih.gov/9521686
https://pubmed.ncbi.nlm.nih.gov/9521686
Autor:
Hansjürgen Volkmer, Maria Thomas, Andreas Lingnau, Dirk Waldherr, Michael H. G. Kubbutat, Achim Knappik, Ralf Brundiers, Angelika Oehmig, Andrea Klotzbücher, Frank Weise, Ursula Hagner, Thomas O. Joos
Publikováno v:
BMC Genomics, Vol 9, Iss 1, p 441 (2008)
BMC Genomics
BMC Genomics
Background The identification of novel drug targets by assessing gene functions is most conveniently achieved by high-throughput loss-of-function RNA interference screening. There is a growing need to employ primary cells in such screenings, since th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4753274b263dc33eccec4b0238d61d93