Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Ralf B. Schittenhelm"'
Autor:
Brooke K. Hayes, Marina Harper, Hariprasad Venugopal, Jessica M. Lewis, Amy Wright, Han-Chung Lee, Joel R. Steele, David L. Steer, Ralf B. Schittenhelm, John D. Boyce, Sheena McGowan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The type VI secretion system (T6SS) is a molecular machine utilised by many Gram-negative bacteria to deliver antibacterial toxins into adjacent cells. Here we present the structure of Tse15, a T6SS Rhs effector from the nosocomial pathogen
Externí odkaz:
https://doaj.org/article/8ac7eabc625b428f98ca3d2616a6f181
Autor:
Yuqin Wu, Ashish Foollee, Andrea Y. Chan, Susanne Hille, Jana Hauke, Matthew P. Challis, Jared L. Johnson, Tomer M. Yaron, Victoria Mynard, Okka H. Aung, Maria Almira S. Cleofe, Cheng Huang, Terry C. C. Lim Kam Sian, Mohammad Rahbari, Suchira Gallage, Mathias Heikenwalder, Lewis C. Cantley, Ralf B. Schittenhelm, Luke E. Formosa, Greg C. Smith, Jürgen G. Okun, Oliver J. Müller, Patricia M. Rusu, Adam J. Rose
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little regarding how glucagon exerts its pleiotropic
Externí odkaz:
https://doaj.org/article/2996febe0d924ecca6c4254d1c0d96ef
Autor:
Elizabeth G. Reisman, Javier Botella, Cheng Huang, Ralf B. Schittenhelm, David A. Stroud, Cesare Granata, Owala S. Chandrasiri, Georg Ramm, Viola Oorschot, Nikeisha J. Caruana, David J. Bishop
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Analyses of mitochondrial adaptations in human skeletal muscle have mostly used whole-muscle samples, where results may be confounded by the presence of a mixture of type I and II muscle fibres. Using our adapted mass spectrometry-based prot
Externí odkaz:
https://doaj.org/article/be9674725b674affb4d1ee6ce2d81638
Autor:
Pok Man Leung, Rhys Grinter, Eve Tudor-Matthew, James P. Lingford, Luis Jimenez, Han-Chung Lee, Michael Milton, Iresha Hanchapola, Erwin Tanuwidjaya, Ashleigh Kropp, Hanna A. Peach, Carlo R. Carere, Matthew B. Stott, Ralf B. Schittenhelm, Chris Greening
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Diverse aerobic bacteria use atmospheric hydrogen (H2) and carbon monoxide (CO) as energy sources to support growth and survival. Such trace gas oxidation is recognised as a globally significant process that serves as the main sink in the bi
Externí odkaz:
https://doaj.org/article/10d161a372d14e91ac81575c40436497
Autor:
Felipe Martelli, Annelise Quig, Sarah Mele, Jiayi Lin, Tahlia L. Fulton, Mia Wansbrough, Christopher K. Barlow, Ralf B. Schittenhelm, Travis K. Johnson, Matthew D. W. Piper
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Drosophila melanogaster is unique among animal models because it has a fully defined synthetic diet available to study nutrient-gene interactions. However, use of this diet is limited to adult studies due to impaired larval development and s
Externí odkaz:
https://doaj.org/article/1402184d5678404da39f83a9a59792eb
Autor:
Felipe Martelli, Jiayi Lin, Sarah Mele, Wendy Imlach, Oguz Kanca, Christopher K. Barlow, Jefferson Paril, Ralf B. Schittenhelm, John Christodoulou, Hugo J. Bellen, Matthew D.W. Piper, Travis K. Johnson
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113861- (2024)
Summary: Inherited metabolic disorders are a group of genetic conditions that can cause severe neurological impairment and child mortality. Uniquely, these disorders respond to dietary treatment; however, this option remains largely unexplored becaus
Externí odkaz:
https://doaj.org/article/37055522b2c8443f94ea3b03560bb55f
Autor:
Shanie Landen, Macsue Jacques, Danielle Hiam, Javier Alvarez-Romero, Ralf B. Schittenhelm, Anup D. Shah, Cheng Huang, Joel R. Steele, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Séverine Lamon, Sarah Voisin, Nir Eynon
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Exercise training elicits changes in muscle physiology, epigenomics, transcriptomics, and proteomics, with males and females exhibiting differing physiological responses to exercise training. However, the molecular mechanisms cont
Externí odkaz:
https://doaj.org/article/9cfe2efed4024313a006a9534e7ee91d
Autor:
Songya Zhang, Lin Zhang, Anja Greule, Julien Tailhades, Edward Marschall, Panward Prasongpholchai, Daniel J. Leng, Jingfan Zhang, Jing Zhu, Joe A. Kaczmarski, Ralf B. Schittenhelm, Oliver Einsle, Colin J. Jackson, Fabrizio Alberti, Andreas Bechthold, Youming Zhang, Manuela Tosin, Tong Si, Max J. Cryle
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3561-3574 (2023)
WS9326A is a peptide antibiotic containing a highly unusual N-methyl-E-2-3-dehydrotyrosine (NMet-Dht) residue that is incorporated during peptide assembly on a non-ribosomal peptide synthetase (NRPS). The cytochrome P450 encoded by sas16 (P450Sas) ha
Externí odkaz:
https://doaj.org/article/7d63ec27ecab4b6da2493ecc0f966b70
Autor:
Katie L. Ayers, Stefanie Eggers, Ben N. Rollo, Katherine R. Smith, Nadia M. Davidson, Nicole A. Siddall, Liang Zhao, Josephine Bowles, Karin Weiss, Ginevra Zanni, Lydie Burglen, Shay Ben-Shachar, Jenny Rosensaft, Annick Raas-Rothschild, Anne Jørgensen, Ralf B. Schittenhelm, Cheng Huang, Gorjana Robevska, Jocelyn van den Bergen, Franca Casagranda, Justyna Cyza, Svenja Pachernegg, David K. Wright, Melanie Bahlo, Alicia Oshlack, Terrence J. O’Brien, Patrick Kwan, Peter Koopman, Gary R. Hime, Nadine Girard, Chen Hoffmann, Yuval Shilon, Amnon Zung, Enrico Bertini, Mathieu Milh, Bochra Ben Rhouma, Neila Belguith, Anu Bashamboo, Kenneth McElreavey, Ehud Banne, Naomi Weintrob, Bruria BenZeev, Andrew H. Sinclair
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Squamous cell carcinoma antigen recognized by T cells 3 (SART3) is an RNA-binding protein with numerous biological functions including recycling small nuclear RNAs to the spliceosome. Here, we identify recessive variants in SART3 in nine ind
Externí odkaz:
https://doaj.org/article/490c3c6f5efa46c79fc60769df8db9e9
Autor:
Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well a
Externí odkaz:
https://doaj.org/article/6d65b18b91de403488fe5eca204df6be