Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ralf Agger"'
Autor:
Bao-cun Zhang, Marlene F. Laursen, Lili Hu, Hossein Hazrati, Ryo Narita, Lea S. Jensen, Aida S. Hansen, Jinrong Huang, Yan Zhang, Xiangning Ding, Maimaitili Muyesier, Emil Nilsson, Agnieszka Banasik, Christina Zeiler, Trine H. Mogensen, Anders Etzerodt, Ralf Agger, Mogens Johannsen, Emil Kofod-Olsen, Søren R. Paludan, Martin R. Jakobsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling
Externí odkaz:
https://doaj.org/article/d5f211afbe2146aea0d8433928886c3f
Autor:
Natasja Bruun, Esben Christensen, Marlene Fyrstenberg Laursen, Trine Søndergaard Jensen, Svend Birkelund, Ralf Agger, Emil Kofod-Olsen
Publikováno v:
Bruun, N, Christensen, E, Laursen, M F, Jensen, T S, Birkelund, S, Agger, R & Kofod-Olsen, E 2022, ' Nucleotide-packaging vaccine leads to in vitro immune activation with low toxicity ', Danish Society of Immunology, Annual Meeting, Aarhus C, Denmark, 25/05/2022-25/05/2022 .
Aalborg University
Aalborg University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fe44ad8feb42a747c3977d551805051f
https://vbn.aau.dk/da/publications/c3f234a6-b6b0-4202-9dc2-ef512e9898bd
https://vbn.aau.dk/da/publications/c3f234a6-b6b0-4202-9dc2-ef512e9898bd
Autor:
Rasmus Virenfeldt Flak, Laurids Poulsen, Mogens Tornby Stender, Gintare Naujokaite, Olga Tcacenco, Alkwin Wanders, Sönke Detlefsen, Ralf Agger, Emil Kofod-Olsen, Ole Thorlacius-Ussing, Morten Ladekarl
Publikováno v:
Flak, R V, Poulsen, L Ø, Stender, M T, Naujokaite, G, Tcacenco, O, Wanders, A, Detlefsen, S, Agger, R, Kofod-Olsen, E, Thorlacius-Ussing, O & Ladekarl, M 2021, A phase II-study of electroporation potentiated immunotherapy in liver metastatic pancreatic cancer (EPIC-1) . in Danske Kræftforskningsdage : Abstract Book ., 40, pp. 51, Danske Kræftforskningsdage 2021, Odense, Denmark, 26/08/2021 .
Aalborg University
Aalborg University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3d2cb6019a18774e8a42d191fb6414af
https://vbn.aau.dk/da/publications/50b89a78-c5e0-4d47-a73d-a77691fc7189
https://vbn.aau.dk/da/publications/50b89a78-c5e0-4d47-a73d-a77691fc7189
Publikováno v:
Fyrstenberg Laursen, M, Kofod-Olsen, E & Agger, R 2019, ' Activation of dendritic cells by targeted DNA : a potential addition to the armamentarium for anti-cancer immunotherapy ', Cancer Immunology, Immunotherapy, vol. 68, no. 11, pp. 1875-1880 . https://doi.org/10.1007/s00262-019-02400-1
In the past decade, remarkable progress has been made in immunotherapy against cancer. Specifically, the introduction of immune checkpoint inhibitors has revolutionized the field. However, many patients are unable to benefit significantly from this t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b8156ccfeaa5cd7705a02db0b87fe9
https://vbn.aau.dk/da/publications/b60b5b41-e968-46ee-9ef2-aad9846f78c9
https://vbn.aau.dk/da/publications/b60b5b41-e968-46ee-9ef2-aad9846f78c9
Publikováno v:
Fredriksen, L, Laursen, M F, Birkelund, S, Agger, R & Kofod-Olsen, E 2019, ' CD11c-targeted dendritic cell vaccine ', Danish Society of Immunology, Annual meeting, København, Denmark, 16/05/2019-16/05/2019 .
Aalborg University
Aalborg University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d7648e8e7c98a5610966b005002dd861
https://vbn.aau.dk/da/publications/512ed312-4421-409c-8335-cab8a49562e5
https://vbn.aau.dk/da/publications/512ed312-4421-409c-8335-cab8a49562e5
Autor:
Martin R. Jakobsen, Marlene Fyrstenberg Laursen, Kasper L Jønsson, Emil Kofod-Olsen, Laura L. T. Degn, Ralf Agger, Esben Christensen
Publikováno v:
Laursen, M F, Christensen, E, Degn, L L T, Jønsson, K, Jakobsen, M R, Agger, R & Kofod-Olsen, E 2018, ' CD11c-targeted delivery of DNA to dendritic cells leads to cGAS-and STING-dependent maturation ', Journal of Immunotherapy, vol. 41, no. 1, pp. 9-18 . https://doi.org/10.1097/CJI.0000000000000195
Laursen, M F, Christensen, E, Degn, L L T, Jønsson, K, Jakobsen, M R, Agger, R & Kofod-Olsen, E 2018, ' CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS-and STING-dependent Maturation ', Journal of Immunotherapy, vol. 41, no. 1, pp. 9-18 . https://doi.org/10.1097/CJI.0000000000000195
Laursen, M F, Christensen, E, Degn, L L T, Jønsson, K, Jakobsen, M R, Agger, R & Kofod-Olsen, E 2018, ' CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS-and STING-dependent Maturation ', Journal of Immunotherapy, vol. 41, no. 1, pp. 9-18 . https://doi.org/10.1097/CJI.0000000000000195
Immunotherapeutic activation of tumor-specific T cells has proven to be an interesting approach in anticancer treatment. Particularly, anti-CTLA-4 and anti-PD-1/PD-L1 treatment looks promising, and conceivably, even better clinical results might be o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37f02769d1f22d36d14f7ee681e1770
https://vbn.aau.dk/da/publications/ddd85507-dcfc-45ee-88b7-647758443f7e
https://vbn.aau.dk/da/publications/ddd85507-dcfc-45ee-88b7-647758443f7e
Publikováno v:
Pugholm, L H, Varming, K & Agger, R 2015, ' In vitro assay for screening of optimal targets for antigen-delivery to murine dendritic cells ', Scandinavian Journal of Immunology, vol. 82, no. 6, pp. 498-505 . https://doi.org/10.1111/sji.12365
Targeting of antigen to dendritic cells (DCs) have been shown to increase the efficiency of immunization procedures and may facilitate the development of more effective vaccines. Several surface molecules on DCs have shown to be useful for antigen ta
Autor:
Meg Duroux, René Johannes Laursen, Linda Pilgaard, Joachim Høg Mortensen, Torben Moos, Preben Sørensen, Ralf Agger, Vladimir Zachar, Mogens Vyberg, Michael Henriksen, Pia Olesen
Publikováno v:
Brain Pathology. 24:360-370
Human glioblastoma multiforme (GBM) is an aggressive cancer with a very poor prognosis. Cripto-1 (CR-1) has a key regulatory role in embryogenesis, while in adult tissue re-expression of CR-1 has been correlated to malignant progression in solid canc
Autor:
Knud Kragballe, Carina A. Rosenberg, Søren R. Paludan, Claus Johansen, Lars Iversen, Mogens Erlandsen, Thomas Vorup-Jensen, Rikke Bech, Babak Jalilian, Ralf Agger, Kristian Otkjaer
Publikováno v:
Bech, R, Jalilian, B, Agger, R, Iversen, L, Erlandsen, M, Otkjaer, K, Johansen, C, Paludan, S R, Rosenberg, C A, Kragballe, K & Vorup-Jensen, T 2016, ' Interleukin 20 regulates dendritic cell migration and expression of co-stimulatory molecules ', Molecular and Cellular Therapies, vol. 4, no. 1 . https://doi.org/10.1186/s40591-016-0046-x
Bech, R, Jalilian, B, Agger, R, Iversen, L, Erlandsen, M, Otkjaer, K, Johansen, C, Paludan, S R, Rosenberg, C A, Kragballe, K & Vorup-Jensen, T 2016, ' Interleukin 20 regulates dendritic cell migration and expression of co-stimulatory molecules ', Molecular and Cellular Therapies, vol. 4, 1 . https://doi.org/10.1186/s40591-016-0046-x
Molecular and Cellular Therapies
Bech, R, Jalilian, B, Agger, R, Iversen, L, Erlandsen, M, Otkjaer, K, Johansen, C, Paludan, S R, Rosenberg, C A, Kragballe, K & Vorup-Jensen, T 2016, ' Interleukin 20 regulates dendritic cell migration and expression of co-stimulatory molecules ', Molecular and Cellular Therapies, vol. 4, 1 . https://doi.org/10.1186/s40591-016-0046-x
Molecular and Cellular Therapies
Background Psoriasis is an inflammatory disease characterized by leukocyte skin infiltration. Interestingly, recent works suggest that the migration of dendritic cells (DCs) is abnormal in psoriatic skin. DCs have significant role in regulating the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6dc3e54ebdef379123238ef2270999
https://pure.au.dk/portal/da/publications/interleukin-20-regulates-dendritic-cell-migration-and-expression-of-costimulatory-molecules(0084d84f-af25-4c56-b9e3-56761d43c121).html
https://pure.au.dk/portal/da/publications/interleukin-20-regulates-dendritic-cell-migration-and-expression-of-costimulatory-molecules(0084d84f-af25-4c56-b9e3-56761d43c121).html
Publikováno v:
Pugholm, L H, Varming, K & Agger, R 2016, ' Antibody-Mediated Delivery of Antigen to Dendritic Cells ', Immunotherapy: Open Access, vol. 2, no. 2, 1000119 . https://doi.org/10.4172/2471-9552.1000119
Dendritic cells (DCs) are specialized antigen-presenting cells that control T cell responses. DCs play a dual role in inducing and orchestrating adaptive immune responses upon infection but also maintaining T cell tolerance. The superior capacity of