Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Ralf A, Linker"'
Autor:
Caroline Reinhardt, Klemens Angstwurm, David Freudenstein, De-Hyung Lee, Christina Wendl, Ralf A. Linker
Publikováno v:
Neurological Research and Practice, Vol 6, Iss 1, Pp 1-9 (2024)
Abstract Background Atrophy of white and grey matter volumes occurs early in the brains of people with multiple sclerosis (pwMS) and has great clinical relevance. In clinical trials, brain atrophy can be quantified by magnetic resonance imaging (MRI)
Externí odkaz:
https://doaj.org/article/9e221952a13b48089f62560aa46bc4f4
Autor:
Sophie Wecker, David Freudenstein, Iris Ganser, Klemens Angstwurm, De-Hyung Lee, Ralf A. Linker
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Background: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system affecting approximately 2.8 million people worldwide. In addition to genetic and environmental factors, various lifestyle factors contribute to dis
Externí odkaz:
https://doaj.org/article/68083bf677ba46708f0be656f3b46eb5
Autor:
Stefanie Haase, Kristina Kuhbandner, Florian Mühleck, Barbara Gisevius, David Freudenstein, Sarah Hirschberg, De-Hyung Lee, Stefanie Kuerten, Ralf Gold, Aiden Haghikia, Ralf A. Linker
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundRecent studies provide increasing evidence for a relevant role of lifestyle factors including diet in the pathogenesis of neuroinflammatory diseases such as multiple sclerosis (MS). While the intake of saturated fatty acids and elevated sal
Externí odkaz:
https://doaj.org/article/976f724651fb444b9c6b48a02f4fbcb3
Autor:
David Freudenstein, Magdalena Lippert, Janina Sophie Popp, Jessica Aprato, Michael Wegner, Elisabeth Sock, Stefanie Haase, Ralf A. Linker, María Nazareth González Alvarado
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Genome-wide association studies identified a single nucleotide polymorphism (SNP) downstream of the transcription factor Sox8, associated with an increased risk of multiple sclerosis (MS). Sox8 is known to influence oligodendrocyte terminal
Externí odkaz:
https://doaj.org/article/b86bdbdcbd9640a9852791d3b9c4047a
Use of the SONAS Ultrasound Device for the Assessment of Cerebral Perfusion in Acute Ischemic Stroke
Autor:
Amir M. Molaie, Sibylle Wilfling, Mustafa Kilic, Christina Wendl, Ralf A. Linker, Felix Schlachetzki, David S. Liebeskind
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 4, Iss 3 (2024)
Background Early recognition of large‐vessel occlusion in acute ischemic stroke is pivotal to ensuring timely and effective treatment. However, current prehospital evaluation strategies largely rely on stroke scales that lack sensitivity and specif
Externí odkaz:
https://doaj.org/article/bfff6f045a5f49aeae2109aea12ada50
Autor:
Olaf Hoffmann, Ralf Gold, Sven G. Meuth, Ralf A. Linker, Thomas Skripuletz, Heinz Wiendl, Mike P. Wattjes
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Magnetic resonance imaging (MRI) of the brain and spinal cord plays a crucial role in the diagnosis and monitoring of multiple sclerosis (MS). There is conclusive evidence that brain and spinal cord MRI findings in early disease stages also provide r
Externí odkaz:
https://doaj.org/article/5152db563333444f9b8b9c3de6d33112
Autor:
Ayse N. Menevse, Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Marcell Kupczyk, Julia Lorenz, Lorraine Weidner, Abir Hussein, Julian Sax, Jasmin Mühlbauer, Nicole Heuschneider, Celine Rohrmus, Laura S. Mai, Birgit Jachnik, Slava Stamova, Valentina Volpin, Franziska C. Durst, Antonio Sorrentino, Maria Xydia, Vladimir M. Milenkovic, Stefanie Bader, Frank K. Braun, Christian Wetzel, Nathalie L. Albert, Joerg-Christian Tonn, Peter Bartenstein, Martin Proescholdt, Nils O. Schmidt, Ralf A. Linker, Markus J. Riemenschneider, Philipp Beckhove, Peter Hau
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with malignancy and poor prognosis, but
Externí odkaz:
https://doaj.org/article/5b085ac5cc8b49e9922c86d6fca1cd96
Autor:
Tareq M. Haedenkamp, Michael F. Leitzmann, Ralf A. Linker, Christoph Meier, Claudia Becker, Susan Jick, Peter Hau, Corinna Seliger
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 3684-3695 (2023)
Abstract Background The use of antibiotics has been associated with increased risks of various cancers. Comprehensive information on the association of antibiotic use with the risk of glioma is lacking. Methods We performed a large case–control stu
Externí odkaz:
https://doaj.org/article/b47548f6118b41a5b774ca8981649799
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 12, Pp 2599-2605 (2023)
Multiple sclerosis is a multifactorial chronic inflammatory disease of the central nervous system that leads to demyelination and neuronal cell death, resulting in functional disability. Remyelination is the natural repair process of demyelination, b
Externí odkaz:
https://doaj.org/article/bc60279e6c4442b68708766c2d6aca63
Autor:
Marlene Tahedl, Seth M. Levine, Robert Weissert, Zacharias Kohl, De-Hyung Lee, Ralf A. Linker, Jens V. Schwarzbach
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background The development of permanent disability in multiple sclerosis (MS) is highly variable among patients, and the exact mechanisms that contribute to this disability remain unknown. Methods Following the idea that the brain has intrin
Externí odkaz:
https://doaj.org/article/dbf0199821d4437ebf1b76a9073b5265