Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Ralf, Schubert"'
Autor:
Marina Reichlmeir, Ruth Pia Duecker, Hanna Röhrich, Jana Key, Ralf Schubert, Kathryn Abell, Anthony P. Possemato, Matthew P. Stokes, Georg Auburger
Publikováno v:
Neurobiology of Disease, Vol 203, Iss , Pp 106756- (2024)
The autosomal recessive disease ataxia-telangiectasia (A-T) presents with cerebellar degeneration, immunodeficiency, radiosensitivity, capillary dilatations, and pulmonary infections. Most symptoms outside the nervous system can be explained by failu
Externí odkaz:
https://doaj.org/article/d4f5a9d28bce480a840e354883c3764f
Autor:
Jochen T. Frueh, Julia Campe, Daniele Yumi Sunaga-Franze, Nikita A. Verheyden, Sakhila Ghimire, Elisabeth Meedt, Denise Haslinger, Sabine Harenkamp, Daniel Staudenraus, Sascha Sauer, Andreas Kreft, Ralf Schubert, Michael Lohoff, Andreas Krueger, Halvard Bonig, Andreas G. Chiocchetti, Robert Zeiser, Ernst Holler, Evelyn Ullrich
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Interferon regulatory factor 4 (IRF4) is a master transcription factor that regulates T helper cell (Th) differentiation. It interacts with the Basic leucine zipper transcription factor, ATF-like (BATF), depletion of which in CD4+ T cells abrogates a
Externí odkaz:
https://doaj.org/article/0e061017555b4bc0b1aa91d36567a9dd
Autor:
Lea Graafen, Annekathrin Heinze, Nawid Albinger, Emilia Salzmann-Manrique, Franziska Ganß, Sabine Hünecke, Claudia Cappel, Sandra Wölke, Helena Donath, Jordis Trischler, Till-Martin Theilen, Christine Heller, Christoph Königs, Stephan Ehl, Peter Bader, Thomas Klingebiel, Jan-Henning Klusmann, Stefan Zielen, Ralf Schubert, Evelyn Ullrich
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Ataxia telangiectasia (AT) is a rare autosomal-recessive disorder characterized by profound neurodegeneration, combined immunodeficiency, and an increased risk for malignant diseases. Treatment options for AT are limited, and the long-term survival p
Externí odkaz:
https://doaj.org/article/cd5c7ce260f64bc4ac1df5a9b6811eee
Autor:
Tanja Hirch, Nadine Brander, Franziska Schenk, Simon J. Pöllmann, Janine Reichenbach, Ralf Schubert, Ute Modlich
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Ataxia telangiectasia is a monogenetic disorder caused by mutations in the ATM gene. Its encoded protein kinase ATM plays a fundamental role in DNA repair of double strand breaks (DSBs). Impaired function of this kinase leads to a multisyste
Externí odkaz:
https://doaj.org/article/0fa81c50e414411d8c70f75fba245208
Autor:
Rebekka Karlowitz, Megan L. Stanifer, Jens Roedig, Geoffroy Andrieux, Denisa Bojkova, Marco Bechtel, Sonja Smith, Lisa Kowald, Ralf Schubert, Melanie Boerries, Jindrich Cinatl, Steeve Boulant, Sjoerd J. L. van Wijk
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-14 (2022)
Abstract Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Type III IFNs (IFN-λ) exhibit cell-type specific and long-lasting functions i
Externí odkaz:
https://doaj.org/article/e0cff6daeb78475a8d5002c6e431347e
Autor:
Nawid Albinger, Rita Pfeifer, Marcus Nitsche, Sarah Mertlitz, Julia Campe, Katja Stein, Hermann Kreyenberg, Ralf Schubert, Melissa Quadflieg, Dina Schneider, Michael W. M. Kühn, Olaf Penack, Congcong Zhang, Nina Möker, Evelyn Ullrich
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 4, Pp 1-9 (2022)
Abstract Acute myeloid leukemia (AML) is a malignant disorder derived from neoplastic myeloid progenitor cells characterized by abnormal proliferation and differentiation. Although novel therapeutics have recently been introduced, AML remains a thera
Externí odkaz:
https://doaj.org/article/6fc0ca3995ea457188b66816b74dd4ba
Autor:
Silvija P. Jerkic, Laura Bächle, Ruth Pia Duecker, Lucia Gronau, Andreas G. Chiocchetti, Stefan Zielen, Ralf Schubert
Publikováno v:
Mediators of Inflammation, Vol 2023 (2023)
Introduction. Bronchiolitis obliterans (BO) is a chronic lung disease, which occurs after an insult to the lower airways, in particular after airway infections or after stem cell transplantation, and which results in persistent inflammation. N–3 an
Externí odkaz:
https://doaj.org/article/0b4097ff71264eceb82b916ba42eabb1
Autor:
Tobias Bexte, Jamal Alzubi, Lisa Marie Reindl, Philipp Wendel, Ralf Schubert, Emilia Salzmann-Manrique, Ivana von Metzler, Toni Cathomen, Evelyn Ullrich
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Natural Killer (NK) cells are known for their high intrinsic cytotoxic capacity, and the possibility to be applied as ‘off-the-shelf’ product makes them highly attractive for cell-based immunotherapies. In patients with multiple myeloma (MM), an
Externí odkaz:
https://doaj.org/article/dabfce889a8d4d1380b4a9666a99c8f1
Autor:
Marina Reichlmeir, Júlia Canet-Pons, Gabriele Koepf, Wasifa Nurieva, Ruth Pia Duecker, Claudia Doering, Kathryn Abell, Jana Key, Matthew P. Stokes, Stefan Zielen, Ralf Schubert, Zoltán Ivics, Georg Auburger
Publikováno v:
Cells, Vol 12, Iss 19, p 2399 (2023)
The autosomal recessive disorder Ataxia-Telangiectasia is caused by a dysfunction of the stress response protein, ATM. In the nucleus of proliferating cells, ATM senses DNA double-strand breaks and coordinates their repair. This role explains T-cell
Externí odkaz:
https://doaj.org/article/db755476b80843dbad5c7f067ecc1ecd
Autor:
Joern Pascal Laubach, Michael Ludwig, Tabea Horn, Olaf Eickmeier, Christina Smaczny, Ralf Schubert, Stefan Zielen, Christof Majoor, Malik Aydin, Alexander Schnell, Sabina Schmitt-Grohé
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 7, p 138 (2023)
Background: High TGFβ1-producing variants cause severe clinical disease in F508del homozygous patients. Lately, we showed that a single nucleotide polymorphism (SNP), rs41266431, in the GJA4 gene modifies the disease severity of cystic fibrosis (CF)
Externí odkaz:
https://doaj.org/article/16d181019809414886fb939000eab2b6