Zobrazeno 1 - 10
of 473
pro vyhledávání: '"Ralf, Hoffmann"'
Autor:
Simon M. Lauer, Maren Reepmeyer, Ole Berendes, Dorota Klepacki, Jakob Gasse, Sara Gabrielli, Helmut Grubmüller, Lars V. Bock, Andor Krizsan, Rainer Nikolay, Christian M. T. Spahn, Ralf Hoffmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Proline-rich antimicrobial peptides (PrAMPs) inhibit bacterial protein biosynthesis by binding to the polypeptide exit tunnel (PET) near the peptidyl transferase center. Api137, an optimized derivative of honeybee PrAMP apidaecin, inhibits p
Externí odkaz:
https://doaj.org/article/6067bc78e2dd47b68285bb91c3a91b6d
Autor:
Chloe Gulliver, Tara Busiau, Ashleigh Byrne, Jane E. Findlay, Ralf Hoffmann, George S. Baillie
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 707-725 (2024)
A robust body of work has demonstrated that a reduction in cAMP‐specific 3′,5′‐cyclic phosphodiesterase 4D isoform 7 (PDE4D7) is linked with negative prostate cancer outcomes; however, the exact molecular mechanism that underpins this relatio
Externí odkaz:
https://doaj.org/article/40e3306a4c564677806f725011d25c00
Autor:
Maria-Christin Jentsch, Sabrina Lübke, Wieland Schrödl, Daniela Volke, Andor Krizsan, Ralf Hoffmann, Sarah Kaiser-Thom, Vinzenz Gerber, Eliane Marti, Bettina Wagner, Christiane L. Schnabel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSevere equine asthma (SEA) is a common chronic disease of adult horses with characteristic recurrent airway obstruction and similarities to neutrophilic asthma in humans. As an extrinsic stimulus, hay dust exposure is a major risk factor
Externí odkaz:
https://doaj.org/article/d80f62be558b44d8927a9406ce33f8d8
Autor:
Alexandra Brakel, Thomas Grochow, Stefanie Fritsche, Daniel Knappe, Andor Krizsan, Simone A. Fietz, Gottfried Alber, Ralf Hoffmann, Uwe Müller
Publikováno v:
Frontiers in Microbiology, Vol 14 (2024)
BackgroundCryptococcosis and cryptococcal meningitis, caused by Cryptococcus neoformans infections, lead to approximately 180,000 deaths per year, primarily in developing countries. Individuals with compromised immune systems, e.g., due to HIV infect
Externí odkaz:
https://doaj.org/article/8215278527a84e1cb030a9085e9ff7f1
Autor:
Christiane L. Schnabel, Maria-Christin Jentsch, Sabrina Lübke, Sarah Kaiser-Thom, Vinzenz Gerber, Susanne Vrtala, Huey-Jy Huang, Claudio Rhyner, Bettina Wagner, Ralf Hoffmann, Daniela Volke
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere equine asthma (SEA) is a common, chronic respiratory disease of horses characterized by hyperreactivity to hay dust which has many similarities to severe neutrophilic asthma in humans. SEA-provoking antigens have not been comprehen
Externí odkaz:
https://doaj.org/article/0af7bc85d53a404f88e729deba3dfb84
Autor:
Karla Rottmayer, Mandy Schwarze, Christian Jassoy, Ralf Hoffmann, Henry Loeffler-Wirth, Claudia Lehmann
Publikováno v:
Biology, Vol 13, Iss 4, p 273 (2024)
Serological assays for SARS-CoV-2 play a pivotal role in the definition of whether patients are infected, the understanding of viral epidemiology, the screening of convalescent sera for therapeutic and prophylactic purposes, and in obtaining a better
Externí odkaz:
https://doaj.org/article/2d0fe87bc38642c1b482ae692b2d01a9
Autor:
Mandy Schwarze, Daniela Volke, Juan Camilo Rojas Echeverri, Robin Schick, Nicole Lakowa, Thomas Grünewald, Johannes Wolf, Stephan Borte, Markus Scholz, Andor Krizsan, Ralf Hoffmann
Publikováno v:
Biology, Vol 13, Iss 4, p 207 (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect human cells by first attaching to the ACE-2 receptor via its receptor-binding domain (RBD) in the spike protein. Here, we report the influence of N-glycosylation sites of the RBD
Externí odkaz:
https://doaj.org/article/cbcbb68c75094c2a8742d092a84ad010
Publikováno v:
Future Science OA, Vol 9, Iss 9 (2023)
Aim: PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated. Patients & methods: RNA
Externí odkaz:
https://doaj.org/article/54a2186f034a4b5fbe5ce12cc796c057
Autor:
Evelien Wynendaele, Nathan Debunne, Yorick Janssens, Anton De Spiegeleer, Frederick Verbeke, Liesa Tack, Sophie Van Welden, Evy Goossens, Daniel Knappe, Ralf Hoffmann, Christophe Van De Wiele, Debby Laukens, Peter Van Eenoo, Lars Vereecke, Filip Van Immerseel, Olivier De Wever, Bart De Spiegeleer
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Colorectal cancer, one of the most common malignancies worldwide, is associated with a high mortality rate, mainly caused by metastasis. Comparative metagenome-wide association analyses of healthy individuals and cancer patients s
Externí odkaz:
https://doaj.org/article/d6a92a983f61486da5164c4800823461
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 6, Pp 2554-2568 (2022)
The global spread of multi- and pan-resistant bacteria has triggered research to identify novel strategies to fight these pathogens, such as antimicrobial peptides and, more recently, bacteriophages. In a proof-of-concept study, we have genetically m
Externí odkaz:
https://doaj.org/article/5441ce64110d4881a3201ac7923003c7