Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ralf, Endres"'
Publikováno v:
Journal of Telecommunications and Information Technology, Iss 2 (2023)
The evaluation of the world’s first MOSFETs with epitaxially-grown rare-earth high-k gate dielectrics is the main issue of this work. Electrical device characterization has been performed on MOSFETs with high-k gate oxides as well as their referenc
Externí odkaz:
https://doaj.org/article/6692ced7642140c19136d5dfd622e1e7
Autor:
Marc Bigaud, Achim Schlapbach, Ina Dix, Ralf Endres, Jean Quancard, Jutta Blank, Frédéric Bornancin, Markus Wartmann, Julien Scesa, Paulo Antonio Fernandes Gomes Dos Santos, Eva Altmann, Thomas Radimerski, Guido Bold, Nicole Buschmann, Samu Melkko, Andreas Weiss, Paul W. Manley, P. Erbel, Oliver Simic, Thomas Zoller, Catherine H. Régnier, Ansgar Schuffenhauer, Elisabeth Buchdunger, Martin Renatus, Paul M.J. McSheehy, Carole Pissot Soldermann
Publikováno v:
Journal of Medicinal Chemistry. 63:14576-14593
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Autor:
Jean Quancard, Laurence Kieffer, Samu Melkko, Ralf Endres, Martin Renatus, Catherine H. Régnier, Thomas Calzascia, Mickael Sorge, Markus Wartmann, Frédéric Bornancin, Thomas Radimerski, P. Erbel, Carole Pissot Soldermann, Paul M.J. McSheehy, Markus Blatter, Reiner Aichholz, Trixie Wagner, Oliver Simic, Karen Beltz, Marc Bigaud, Achim Schlapbach, Andreas Weiss
Publikováno v:
Journal of Medicinal Chemistry. 63:14594-14608
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds to explore the therapeutic potential of this target. Here, we report
Autor:
Carole, Pissot Soldermann, Oliver, Simic, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Markus, Wartmann, Marc, Bigaud, Andreas, Weiss, Paul, McSheehy, Ralf, Endres, Paulo, Santos, Jutta, Blank, Ansgar, Schuffenhauer, Guido, Bold, Nicole, Buschmann, Thomas, Zoller, Eva, Altmann, Paul W, Manley, Ina, Dix, Elisabeth, Buchdunger, Julien, Scesa, Jean, Quancard, Achim, Schlapbach, Frédéric, Bornancin, Thomas, Radimerski, Catherine H, Régnier
Publikováno v:
Journal of medicinal chemistry. 63(23)
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Autor:
Jean, Quancard, Oliver, Simic, Carole, Pissot Soldermann, Reiner, Aichholz, Markus, Blatter, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Ralf, Endres, Mickael, Sorge, Laurence, Kieffer, Trixie, Wagner, Karen, Beltz, Paul, Mcsheehy, Markus, Wartmann, Catherine H, Régnier, Thomas, Calzascia, Thomas, Radimerski, Marc, Bigaud, Andreas, Weiss, Frédéric, Bornancin, Achim, Schlapbach
Publikováno v:
Journal of medicinal chemistry. 63(23)
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds to explore the therapeutic potential of this target. Here, we report
N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity
Autor:
Markus Wartmann, Ralf Endres, Jean Quancard, Richard Heng, Laszlo Revesz, Frédéric Bornancin, Samu Melkko, Achim Schlapbach, Catherine H. Régnier, Martin Renatus, Carole Pissot Soldermann, Oliver Simic, Ansgar Schuffenhauer, P. Erbel, Thomas Zoller, Jutta Blank, Thomas Radimerski
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(12)
Starting from a weak screening hit, potent and selective inhibitors of the MALT1 protease function were elaborated. Advanced compounds displayed high potency in biochemical and cellular assays. Compounds showed activity in a mechanistic Jurkat T cell
Publikováno v:
Microelectronic Engineering. 88:3393-3398
In this work, we present MOS capacitors and field effect transistors with a crystalline gadolinium oxide (Gd"2O"3) gate dielectric and metal gate electrode (titanium nitride) fabricated in a gentle damascene gate last process. Details of the gate las
Autor:
Rita Andraos, Thomas Radimerski, Elisabeth Buchdunger, Andreas Weiss, Catherine H. Régnier, Jean Quancard, Markus Wartmann, Dario Sterker, Paul M.J. McSheehy, Achim Schlapbach, Frédéric Bornancin, Daniel Wyss, Martin Renatus, Carole Pissot, Francesco Hofmann, Ralf Endres, Oliver Simic, William R. Sellers, Marc Bigaud, Alexandra Buhles
Publikováno v:
Cancer Research. 78:1879-1879
Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin's lymphoma, comprising 30% to 40% of all newly diagnosed cases. DLBCL is a biologically and clinically diverse disease with more than a dozen subtypes classi
Publikováno v:
Microelectronic Engineering. 85:15-19
This paper presents the first successful attempt to integrate crystalline high-k gate dielectrics into a virtually damage-free damascene metal gate process. Process details as well as initial electrical characterization results on fully functional ga
Publikováno v:
Microelectronics Reliability. 47:528-531
This paper presents the first successful attempt to integrate crystalline high-K gate dielectrics into a virtually damage-free damascene metal gate process. Process details as well as initial electrical characterization results on fully functional ga