Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rakshita A. Charan"'
Autor:
Defne A. Amado, Alice Chen-Plotkin, Yunji Seo, Rakshita A. Charan, Maria Diaz-Ortiz, Rebecca Zack, Travis L. Unger, Johanna I. Busch, Elisia M. Clark
Publikováno v:
SSRN Electronic Journal.
Frontotemporal lobar degeneration (FTLD) is a leading cause of early-onset dementia, but the pathological mechanisms underlying this disorder are not well understood. Common variants in the gene encoding Transmembrane Protein 106B (TMEM106B) increase
Autor:
Katsuya Inagaki, Kei Adachi, Maliha Zahid, Rakshita A. Charan, Hiroyuki Nakai, Nicole M. Kotchey, Robert S. Parker
Publikováno v:
Molecular Therapy. 19(6):1079-1089
Recombinant adeno-associated virus serotype 9 (rAAV9) vectors show robust in vivo transduction by a systemic approach. It has been proposed that rAAV9 has enhanced ability to cross the vascular endothelial barriers. However, the scientific basis of s
Autor:
Rakshita A. Charan, Matthew J. LaVoie
Publikováno v:
Molecular and cellular neurosciences. 66
Mutations in the E3 ligase parkin are the most common cause of autosomal recessive Parkinson's disease (PD), but it is believed that parkin dysfunction may also contribute to idiopathic PD. Since its discovery, parkin has been implicated in supportin
Publikováno v:
Cell Death & Disease
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, affecting 1–3% of the population over 65. Mutations in the ubiquitin E3 ligase parkin are the most common cause of autosomal recessive PD. The parkin protein posses
Autor:
Nimansha Jain, Alice Chen-Plotkin, Rakshita A. Charan, Travis L. Unger, R. Tyler Skrinak, Johanna I. Busch
Publikováno v:
Human Molecular Genetics. :ddw127
Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is an important cause of dementia in individuals under age 65. Common variants in the TMEM106B gene were previously discovered by genome-wide association to confer genetic risk for F
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(2)
Duchenne muscular dystrophy (DMD) is caused by the lack of a functional dystrophin protein that results in muscle fiber membrane disruption and, ultimately, degeneration. Regeneration of muscle fibers fails progressively, and muscle tissue is replace
Publikováno v:
Journal of neurobiology. 66(4)
Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) are involved in acetylcholine synthesis and degradation at pre- and postsynaptic compartments, respectively. Here we show that their anterograde transport in Drosophila larval ganglion
Publikováno v:
Cell Cycle
literature predicting a direct downstream function within a highly conserved cell death pathway. Soon after the cloning of the PARKIN gene, numerous studies shed light on the function of parkin. Parallel efforts from many groups also revealed that pa