Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rakshin Kharwadkar"'
Autor:
Michelle Chu, Huanling Gao, Patricia Esparza, Abigail Pajulas, Jocelyn Wang, Rakshin Kharwadkar, Hongyu Gao, Mark H. Kaplan, Robert S. Tepper
Publikováno v:
Physiological Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract Populations that are born and raised at high altitude develop under conditions of chronic developmental hypoxia (CDH), which results in pulmonary adaptations of increased lung volume and diffusion capacity to increase gas exchange. It is not
Externí odkaz:
https://doaj.org/article/a2db0584fdb340c8a0d9dd0167af98ca
Autor:
Lisanne Heim, Zuqin Yang, Patrick Tausche, Katja Hohenberger, Mircea T. Chiriac, Julia Koelle, Carol-Immanuel Geppert, Katerina Kachler, Sarah Miksch, Anna Graser, Juliane Friedrich, Rakshin Kharwadkar, Ralf J. Rieker, Denis I. Trufa, Horia Sirbu, Markus F. Neurath, Mark H. Kaplan, Susetta Finotto
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Although lung cancer is the leading cause of cancer deaths worldwide, the mechanisms how lung cancer cells evade the immune system remain incompletely understood. Here, we discovered IL-9-dependent signaling mechanisms that drive immune evasion in no
Externí odkaz:
https://doaj.org/article/123c1359ce714a9b810a0f1bd63a872f
Autor:
Yongyao Fu, Jocelyn Wang, Gayathri Panangipalli, Benjamin J. Ulrich, Byunghee Koh, Chengxian Xu, Rakshin Kharwadkar, Xiaona Chu, Yue Wang, Hongyu Gao, Wenting Wu, Jie Sun, Robert S. Tepper, Baohua Zhou, Sarath Chandra Janga, Kai Yang, Mark H. Kaplan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
BATF is a transcription factor that is needed for IL-9 production by T helper 9 cells. Here the authors show that STAT5 is needed at the Il9 locus to enable BATF to function in this manner and that this interaction can reprogram other T helper subset
Externí odkaz:
https://doaj.org/article/f65e400bd7f5452ca8fba9f15ba2dcc0
Autor:
Rakshin Kharwadkar, Benjamin J. Ulrich, Michelle Chu, Byunghee Koh, Matthew M. Hufford, Yongyao Fu, Graeme M. Birdsey, Bo T. Porse, Anna M. Randi, Mark H. Kaplan
Publikováno v:
The Journal of Immunology. 210:537-546
CD4+ TH cells develop into subsets that are specialized in the secretion of particular cytokines to mediate restricted types of inflammation and immune responses. Among the subsets that promote development of allergic inflammatory responses, IL-9–p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66b7d6c84c4170873d620b8d400d2304
https://doi.org/10.4049/jimmunol.2200113
https://doi.org/10.4049/jimmunol.2200113
Autor:
Benjamin J. Ulrich, Rakshin Kharwadkar, Michelle Chu, Abigail Pajulas, Charanya Muralidharan, Byunghee Koh, Yongyao Fu, Hongyu Gao, Tristan A. Hayes, Hong-Ming Zhou, Nick P. Goplen, Andrew S. Nelson, Yunlong Liu, Amelia K. Linnemann, Matthew J. Turner, Paula Licona-Limón, Richard A. Flavell, Jie Sun, Mark H. Kaplan
Publikováno v:
Science Immunology. 7
Asthma is a chronic inflammatory lung disease with intermittent flares predominately mediated through memory T cells. Yet, the identity of long-term memory cells that mediate allergic recall responses is not well defined. In this report, using a mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222bfca7aa6535e7434174194fde4df6
https://doi.org/10.1126/sciimmunol.abg9296
https://doi.org/10.1126/sciimmunol.abg9296
Autor:
Paula Licona-Limón, Byunghee Koh, Benjamin J. Ulrich, Amina Abdul Qayum, Richard A. Flavell, Rakshin Kharwadkar, Mark H. Kaplan
Publikováno v:
ImmunoHorizons. 4:282-291
Generation of allelic gene reporter mice has provided a powerful tool to study gene function in vivo. In conjunction with imaging technologies, reporter mouse models facilitate studies of cell lineage tracing, live cell imaging, and gene expression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd0eceaf06d5ff3ef86e1c8c7296c58
https://doi.org/10.4049/immunohorizons.1900082
https://doi.org/10.4049/immunohorizons.1900082
Autor:
Rakshin Kharwadkar, Byunghee Koh, Benjamin J. Ulrich, Makoto Kuwahara, Mark H. Kaplan, Masakatsu Yamashita, Yongyao Fu
Publikováno v:
J Immunol
The basic leucine zipper (bZIP) transcription factor BATF is expressed in multiple Th subsets and cooperates with other factors to regulate gene transcription. BATF activates lineage-specific cytokines in Th subsets, activating IL-9 in Th9 cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdbbba95c627dd0eebd5c7a070f50a0
https://doi.org/10.4049/jimmunol.1900128
https://doi.org/10.4049/jimmunol.1900128
Autor:
Daniel H. Conrad, Yongyao Fu, Byunghee Koh, Wenting Wu, Amina Abdul Qayum, Mark H. Kaplan, Rakshin Kharwadkar, Blake T. Kenworthy, Rebecca K. Martin
Publikováno v:
J Immunol
IL-9 is an important mediator of allergic disease that is critical for mast cell–driven diseases. IL-9 is produced by many cell types, including T cells, basophils, and mast cells. Yet, how IL-9 is regulated in mast cells or basophils is not well c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da81afdf47bdcf9432dc3732e6d35987
https://doi.org/10.4049/jimmunol.1900272
https://doi.org/10.4049/jimmunol.1900272
Autor:
Rakshin Kharwadkar, Horia Sirbu, Julia Koelle, Katerina Kachler, Zuqin Yang, Katja Hohenberger, Anna Graser, Denis I. Trufa, Markus F. Neurath, Lisanne Heim, Sarah Mitsch, Patrick Tausche, Ralf J. Rieker, Carol-Immanuel Geppert, Susetta Finotto, Mark H. Kaplan, Juliane Friedrich, Mircea T. Chiriac
Publikováno v:
SSRN Electronic Journal.
Although lung cancer is the leading cause of cancer death worldwide, the mechanisms how lung cancer cells evade the immune system remain incompletely understood. Here, we discovered IL-9-dependent signaling mechanisms that drive immune evasion in non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4229d20efafc662c3ffe09b0a94fa2e4
https://doi.org/10.2139/ssrn.3944543
https://doi.org/10.2139/ssrn.3944543
Autor:
Jie Sun, Xiaona Chu, Yue Wang, Yongyao Fu, Robert S. Tepper, Chengxian Xu, Sarath Chandra Janga, Jocelyn Wang, Mark H. Kaplan, Wenting Wu, Byunghee Koh, Gayathri Panangipalli, Hongyu Gao, Rakshin Kharwadkar, Baohua Zhou, Kai Yang, Benjamin J. Ulrich
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
T helper cell differentiation requires lineage-defining transcription factors and factors that have shared expression among multiple subsets. BATF is required for development of multiple Th subsets but functions in a lineage-specific manner. BATF is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3aa0728bc91df959076b0c36eb41fa
http://europepmc.org/articles/PMC7523001
http://europepmc.org/articles/PMC7523001