Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study.

Autor: Carcache de Blanco EJ; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA. kinghorn.4@osu.edu., Addo EM; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA. kinghorn.4@osu.edu., Rakotondraibe HL; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA. kinghorn.4@osu.edu., Soejarto DD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.; Science and Education, Field Museum, Chicago, IL 60605, USA., Kinghorn AD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA. kinghorn.4@osu.edu.

Publikováno v: Natural product reports [Nat Prod Rep] 2023 Jul 19; Vol. 40 (7), pp. 1181-1197. Date of Electronic Publication: 2023 Jul 19.

Understanding the Biosynthesis of Paxisterol in Lichen-Derived Penicillium aurantiacobrunneum for Production of Fluorinated Derivatives.

Autor: Yamano Y; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.; Graduate School of Biomedical and Health Sciences, Pharmaceutical Sciences, Hiroshima University, Hiroshima 739-8527, Japan., Rakotondraibe HL; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.; Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210, USA.; Center for Applied Plant Sciences, The Ohio State University, Columbus, OH 43210, USA.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Mar 02; Vol. 27 (5). Date of Electronic Publication: 2022 Mar 02.

Spermidine alkaloid and glycosidic constituents of Vietnamese Homalium cochinchinensis .

Autor: Addo EM; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Ren Y; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Anaya-Eugenio GD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Ninh TN; Vietnam Academy of Science and Technology, Hanoi, Vietnam., Rakotondraibe HL; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., de Blanco EJC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA., Soejarto DD; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.; Science and Education, Field Museum of Natural History, Chicago, IL 60605, USA., Kinghorn AD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

Publikováno v: Phytochemistry letters [Phytochem Lett] 2021 Jun; Vol. 43, pp. 154-162. Date of Electronic Publication: 2021 Apr 15.

Semi-synthetic cinnamodial analogues: Structural insights into the insecticidal and antifeedant activities of drimane sesquiterpenes against the mosquito Aedes aegypti.

Autor: Manwill PK; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America.; Center for Applied Plant Sciences, The Ohio State University, Columbus, Ohio, United States of America., Kalsi M; Department of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, Ohio, United States of America., Wu S; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America., Martinez Rodriguez EJ; Department of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, Ohio, United States of America., Cheng X; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America., Piermarini PM; Center for Applied Plant Sciences, The Ohio State University, Columbus, Ohio, United States of America.; Department of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, Ohio, United States of America., Rakotondraibe HL; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America.; Center for Applied Plant Sciences, The Ohio State University, Columbus, Ohio, United States of America.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Feb 26; Vol. 14 (2), pp. e0008073. Date of Electronic Publication: 2020 Feb 26 (Print Publication: 2020).

Discovery of Anticancer Agents of Diverse Natural Origin.

Autor: Kinghorn AD; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A. kinghorn.4@osu.edu.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A., DE Blanco EJ; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A., Lucas DM; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.; College of Medicine, The Ohio State University, Columbus, OH, U.S.A., Rakotondraibe HL; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A., Orjala J; College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A., Soejarto DD; College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A.; Field Museum of Natural History, Chicago, IL, U.S.A., Oberlies NH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, U.S.A., Pearce CJ; Mycosynthetix, Inc., Hillsborough, NC, U.S.A., Wani MC; Research Triangle Institute, Research Triangle Park, NC, U.S.A., Stockwell BR; Department of Biological Sciences, Columbia University, New York, NY, U.S.A.; Department of Chemistry, Columbia University, New York, NY, U.S.A., Burdette JE; College of Pharmacy, University of Illinois at Chicago, Chicago, IL, U.S.A., Swanson SM; School of Pharmacy, University of Wisconsin-Madison, Madison, WI, U.S.A., Fuchs JR; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A., Phelps MA; College of Pharmacy, The Ohio State University, Columbus, OH, U.S.A.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A., Xu L; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A., Zhang X; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, U.S.A.; College of Medicine, The Ohio State University, Columbus, OH, U.S.A., Shen YY; Eisai Inc., Andover, MA, U.S.A.

Publikováno v: Anticancer research [Anticancer Res] 2016 Nov; Vol. 36 (11), pp. 5623-5637.