Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Rakhi B. Shah"'
Autor:
Cyrus Agarabi, Rakhi B. Shah, Erik K. Read, Mansoor A. Khan, David Awotwe-Otoo, Scott Lute, Kurt Brorson
Publikováno v:
International Journal of Pharmaceutics. 450:70-78
An efficient and potentially scalable technology was evaluated to control the ice nucleation step of the freezing process for a model monoclonal antibody formulation and the effect on process performance and quality attributes of the final lyophilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2fadd0d03d82332258d738dfdd451f
https://doi.org/10.1016/j.ijpharm.2013.04.041
https://doi.org/10.1016/j.ijpharm.2013.04.041
Autor:
Alan S. Carlin, Mansoor A. Khan, Yongsheng Yang, Rakhi B. Shah, Lawrence X. Yu, Srikant Bykadi
Publikováno v:
Journal of Pharmaceutical Sciences. 102:1370-1381
The aims of this study were to systematically evaluate the effects of pH levels, phosphate concentrations, and tablet integrity on the phosphate binding profiles of lanthanum carbonate chewable tablets, and to compare the in vitro phosphate binding e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1daadee2339ee4902d300a426c6f076
https://doi.org/10.1002/jps.23454
https://doi.org/10.1002/jps.23454
Publikováno v:
Molecular Pharmaceutics. 10:544-550
A conventional human pharmacokinetic (PK) in vivo study is often considered as the "gold standard" to determine bioequivalence (BE) of drug products. However, this BE approach is not always applicable to the products not intended to be delivered into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ea8fd86c082a0c120ea1c748a3f187
https://doi.org/10.1021/mp300517p
https://doi.org/10.1021/mp300517p
Autor:
Yellela S.R. Krishnaiah, Rakhi B. Shah, Prashanth Manda, Naresh Pavurala, Usha Katragadda, Mansoor A. Khan, Guodong Fang, Yang Yang, Yongsheng Yang
Publikováno v:
AAPS PharmSciTech. 18(6)
Study objective was to assess skin-to-skin drug transfer potential that may occur due to drug retention in human epidermis (DRE) pretreated with application of estradiol transdermal drug delivery systems (TDDS) and other estradiol transdermal dosage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4668dae0c717a64dbbaec9716fd04cef
https://pubmed.ncbi.nlm.nih.gov/28028793
https://pubmed.ncbi.nlm.nih.gov/28028793
Autor:
David A. Keire, Rakhi B. Shah, Sau L. Lee, Mansoor A. Khan, Cyrus Agarabi, Lawrence X. Yu, Muhammad J. Habib, Andre Raw, David Awotwe-Otoo
Publikováno v:
The AAPS Journal. 14:619-626
The purpose of this study was to characterize and evaluate differences of protamine sulfate, a highly basic peptide drug, obtained from five different sources, using orthogonal thermal and spectroscopic analytical methods. Thermogravimetric analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c052f7aae2734c7f42363967f71ee122
https://doi.org/10.1208/s12248-012-9375-0
https://doi.org/10.1208/s12248-012-9375-0
Autor:
Dayue Chen, Kurt Brorson, Rakhi B. Shah, Erik K. Read, Daniel Strauss, Adith Venkiteshwaran, Scott Lute, A Kreuzman, George Miesegaes, Parviz Ayazi Shamlou
Publikováno v:
Biotechnology and Bioengineering. 109:2048-2058
Traditionally, post-production culture harvest capture of therapeutic monoclonal antibodies (mAbs) is performed using Protein A chromatography. We investigated the efficiency and robustness of cation exchange chromatography (CEX) in an effort to eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3b84a5f99618d8d7be0ada3ad19671
https://doi.org/10.1002/bit.24480
https://doi.org/10.1002/bit.24480
Autor:
Rakhi B. Shah, David Awotwe-Otoo, Muhammad J. Habib, Cyrus Agarabi, Sau Lee, Patrick J. Faustino, Mansoor A. Khan
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 62:61-67
The purpose of this study was to develop a robust reverse phase-HPLC method for the separation of hydrolyzed protamine sulfate peptides using a quality by design approach. A Plackett-Burman experimental design was utilized to screen the effects of mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db4930a05bebaed531ea2e39d1842d5
https://doi.org/10.1016/j.jpba.2012.01.002
https://doi.org/10.1016/j.jpba.2012.01.002
Publikováno v:
AAPS PharmSciTech. 12:442-448
As stipulated by ICH Q8 R2 (1), prediction of critical process parameters based on process modeling is a part of enhanced, quality by design approach to product development. In this work, we discuss a Bayesian model for the prediction of primary dryi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e03e47f1ec3531e0d3a5f9ba069ba4
https://doi.org/10.1208/s12249-011-9598-x
https://doi.org/10.1208/s12249-011-9598-x
Autor:
Jarrod S. Collier, Arthur Bryant, Vilayat A. Sayeed, Muhammad J. Habib, Rakhi B. Shah, Mansoor A. Khan
Publikováno v:
AAPS PharmSciTech. 11:1359-1367
Levothyroxine is a narrow therapeutic index, and to avoid adverse effect associated with under or excessive dosage, the dose response is carefully titrated. The tablets are marketed with a score providing an option to split. However, there are no sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde2054d07952712bd01603318cb57fe
https://doi.org/10.1208/s12249-010-9515-8
https://doi.org/10.1208/s12249-010-9515-8
Autor:
Andre Raw, Yongsheng Yang, Mansoor A. Khan, Patrick J. Faustino, Rakhi B. Shah, Lawrence X. Yu
Publikováno v:
Journal of Pharmaceutical Sciences. 99:142-153
A high performance gel permeation chromatography (HP-GPC) method was developed, validated and used to determine the molecular weight (MW) of sodium ferric gluconate following various stress conditions. The intra-day accuracy (90-103%), intra-day prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5aca108106dec6cbf3ddec4e82d74d9
https://doi.org/10.1002/jps.21806
https://doi.org/10.1002/jps.21806