Výsledky vyhledávání - "Rakhee S. Gupte"

G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases

Autor: Sachin A. Gupte, Connie Zheng, Rakhee S. Gupte, Christina Jacob, Atsushi Kitagawa, John G. Edwards, Vidhi Dhagia, Petra Rocic, Angelo D'Alessandro

Publikováno v: Am J Physiol Heart Circ Physiol

We aimed to determine 1) the mechanism(s) that enables glucose-6-phosphate dehydrogenase (G6PD) to regulate serum response factor (SRF)- and myocardin (MYOCD)-driven smooth muscle cell (SMC)-restricted gene expression, a process that aids in the diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc92ea86752b3c66d53d925d044007f6
https://doi.org/10.1152/ajpheart.00488.2020

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CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean G6PD Variant

Autor: Joseph M. Miano, Sachin A. Gupte, Igor V. Kizub, Kevin Michael, Petra Rocic, Michael Grzybowski, Atsushi Kitagawa, Christina Jacob, Aron M. Geurts, Rakhee S. Gupte, Julie A. Reisz, Angelo D'Alessandro

Publikováno v: Hypertension. 76:523-532

Epidemiological studies suggest that individuals in the Mediterranean region with a loss-of-function, nonsynonymous single nucleotide polymorphism (S188F), in glucose-6-phosphate dehydrogenase ( G6pd ) are less susceptible to vascular diseases. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d59f0a9d46d372f6a7747c6aea57e8f7
https://doi.org/10.1161/hypertensionaha.120.14772

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Glucose-6-phosphate dehydrogenase increases Ca2+currents by interacting with Cav1.2 and reducing intrinsic inactivation of the L-type calcium channel

Autor: Vidhi Dhagia, Rakhee S. Gupte, Sachin A. Gupte, Rikuo Ochi, Petra Rocic

Publikováno v: Am J Physiol Heart Circ Physiol

Pyridine nucleotides, such as NADPH and NADH, are emerging as critical players in the regulation of heart and vascular function. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, is the primary sourc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948b09d6fe35798a0c634eb66b2b13e3
https://doi.org/10.1152/ajpheart.00727.2019

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Increased Reactive Oxygen Species, Metabolic Maladaptation, and Autophagy Contribute to Pulmonary Arterial Hypertension–Induced Ventricular Hypertrophy and Diastolic Heart Failure

Autor: Takao Okada, Sachin A. Gupte, Abdallah Alzoubi, Andrea G. Kahn, Dhawjbahadur K. Rawat, Ivan F. McMurtry, Rakhee S. Gupte, Makino Watanabe, Sukrutha Chettimada

Publikováno v: Hypertension. 64:1266-1274

Pulmonary arterial hypertension (PAH) is a debilitating and deadly disease with no known cure. Heart failure is a major comorbidity and a common cause of the premature death of patients with PAH. Increased asymmetrical right ventricular hypertrophy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09839054557c6891cd8e788084ed736
https://doi.org/10.1161/hypertensionaha.114.03261

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Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats

Autor: Sukrutha Chettimada, Rakhee S. Gupte, Sachin A. Gupte, Sarah A. Gebb, Ivan F. McMurtry, Abdallah Alzoubi, Sachindra R. Joshi

Publikováno v: Am J Physiol Lung Cell Mol Physiol

Although hypoxia is detrimental to most cell types, it aids survival of progenitor cells and is associated with diseases like cancer and pulmonary hypertension in humans. Therefore, understanding the underlying mechanisms that promote survival of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd83ed4c4f59be73f0d6ff6d0f23387
https://doi.org/10.1152/ajplung.00303.2013

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Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency

Autor: Vidhi Dhagia, Joseph M. Miano, Alessandro Aiezza, Sachin A. Gupte, Thomas M. Lincoln, Sachindra R. Joshi, Rakhee S. Gupte, Sukrutha Chettimada

Publikováno v: American journal of physiology. Heart and circulatory physiology. 311(4)

Homeostatic control of vascular smooth muscle cell (VSMC) differentiation is critical for contractile activity and regulation of blood flow. Recently, we reported that precontracted blood vessels are relaxed and the phenotype of VSMC is regulated fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484ee6eb1e95551d2934f37deb87bcc1
https://pubmed.ncbi.nlm.nih.gov/27521420

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Glucose-6-Phosphate Dehydrogenase Is a Regulator of Vascular Smooth Muscle Contraction

Autor: Madoka Abe, Rakhee S. Gupte, Sachin A. Gupte, Dhawjbahadur K. Rawat, Rikuo Ochi, Hirotaka Ata, Mark S. Taylor

Publikováno v: Antioxidants & Redox Signaling. 14:543-558

Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in the pentose phosphate pathway and a major source of nicotinamide adenine dinucleotide phosphate reduced (NADPH), which regulates numerous enzymatic (including glutathione reducta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365a5e8a55eb26a24bdd740284237b39
https://doi.org/10.1089/ars.2010.3207

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Activation of Glucose-6-phosphate Dehydrogenase Promotes Acute Hypoxic Pulmonary Artery Contraction

Autor: Sachin A. Gupte, Michael S. Wolin, Rakhee S. Gupte, Donna L. Cioffi, Dhawjbahadur K. Rawat, Sukrutha Chettimada, William T. Gerthoffer, Ivan F. McMurtry

Publikováno v: Journal of Biological Chemistry. 285:19561-19571

Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to a decrease in airway O(2) tension, but the underlying mechanism is incompletely understood. We studied the contribution of glucose-6-phosphate dehydrogenase (Glc-6-PD), an import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea13a284b664ee12318f3617fb7c72ff
https://doi.org/10.1074/jbc.m109.092916

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Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver

Autor: Zoltan Ungvari, Michael S. Wolin, Rakhee S. Gupte, Mark Kozicky, Vanessa Neito, Sachin A. Gupte, Beverly C. Floyd, Shimran George

Publikováno v: Free Radical Biology and Medicine. 47:219-228

Type 2 diabetes affects approximately 170 million people around the world and these numbers are rapidly rising every year [1]. This metabolic syndrome is now widely recognized as a risk factor for liver disorders, obesity and cardiovascular diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94f8d49cb72c979d38d6a3bbf2a6054
https://doi.org/10.1016/j.freeradbiomed.2009.01.028

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HDAC Expression and Activity in Vascular Smooth Muscle Cells is Regulated by Glucose‐6‐Phosphate Dehydrogenase

Autor: Rakhee S. Gupte, Vidhi Dhagia, Sachin A. Gupte

Publikováno v: The FASEB Journal. 29

Glucose-6-phosphate dehydrogenase (G6PD), a key enzyme in the glucose metabolism, regulates vascular smooth muscle cell (VSMC) phenotype and function. In proteomic analysis, we discovered that G6PD formed a complex with histone acyltransferase (KAT6A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0918b2478458bee1cba7e13688c1120
https://doi.org/10.1096/fasebj.29.1_supplement.1052.3

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