A secondary RET mutation in the activation loop conferring resistance to vandetanib

Autor: Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald, Koichi Goto

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

Mechanisms of acquired resistance to RET tyrosine kinase inhibitors in lung cancers are largely unknown. Here, the authors report in a lung adenocarcinoma patient harboring a CCDC6-RET mutation in the RET kinase (S904F) that results in resistance to

Externí odkaz: https://doaj.org/article/5dda588c6b064bfcbe3ac0b3c008bd63

Introducing physician associates to hospital patients: Development and feasibility testing of a patient experience‐based intervention

Autor: Jonathan Ogidi, Francesca Taylor, Sally Brearley, Zeena Ladva, Rakhee Chauhan, Vari Drennan

Publikováno v: Health Expectations : An International Journal of Public Participation in Health Care and Health Policy
Health Expectations, Vol 24, Iss 1, Pp 77-86 (2021)

Background Physician associates (PAs) are one of many new mid-level health practitioner roles being introduced worldwide. They are a recent innovation in English hospitals. Patient confusion with novel mid-level practitioner titles and roles is well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4a8e61c9563d24da26c6b79b2765c1
https://doi.org/10.1111/hex.13149

RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements

Autor: Pascal Meier, Rachael Barry, Ivan Plaza-Menacho, Stephane Mouilleron, Neil Q. McDonald, Mariam Orme, Annabel Borg, Rubén J. Martínez-Torres, Rakhee Chauhan, Karin Barnouin

Publikováno v: Cell Reports, Vol 17, Iss 12, Pp 3319-3332 (2016)
Cell Reports

Summary Receptor tyrosine kinases exhibit a variety of activation mechanisms despite highly homologous catalytic domains. Such diversity arises through coupling of extracellular ligand-binding portions with highly variable intracellular sequences fla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2821f580de1a06fc7821c0b8413a38
https://doi.org/10.1016/j.celrep.2016.11.061

2020 – ACTIVATION OF THE RECEPTOR TYROSINE KINASE (RET) BY GDNF/GFRa1 IMPROVES CORD BLOOD-DERIVED HSC IN VITRO EXPANSION AND IN VIVO ENGRAFTMENT

Autor: Rakhee Chauhan, Marion Piganneau, Hector Huerga-Encabo, Manuel Garcia-Albornoz, Neil Q. McDonald, William Grey, Dominique Bonnet

Publikováno v: Experimental Hematology. 88:S35

Allogeneic hematopoietic stem cell (HSC) transplantation is the gold standard therapy for numerous hematological disorders, but limitations exist in HSC number available per donor and our relative inability to successfully expand transplantable HSCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57ac1a23cae84aeaf4a2ed485e76ad59
https://doi.org/10.1016/j.exphem.2020.09.182

P062. An audit of prepectoral breast reconstructions using the Braxon® acellular dermal matrix (ADM)

Autor: Sarah Tang, Matt Dunstan, Anup Sharma, Rakhee Chauhan, D. Banerjee, Paige Bishop

Publikováno v: European Journal of Surgical Oncology. 45:901-902

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e78c39ccd99363bb36ac34f002509c9
https://doi.org/10.1016/j.ejso.2019.01.084