Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Rakesh K. Sit"'
Autor:
Nathan M. Samskey, Palmer Taylor, Zoran Radić, Arnold Garcia, Yadira Sepulveda, Rakesh K. Sit, K. Barry Sharpless, Jeremiah D. Momper, Yan Jye Shyong
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 378:315-321
Inhibition of acetylcholinesterase (AChE) by certain organophosphates (OPs) can be life-threatening and requires reactivating antidote accessibility to the peripheral and central nervous systems to reverse symptoms and enhance survival parameters. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91471633449ad7f8cc9ca68c86ba077
https://doi.org/10.1124/jpet.121.000715
https://doi.org/10.1124/jpet.121.000715
Autor:
Palmer Taylor, Carol E. Green, Nikolina Maček Hrvat, Valery V. Fokin, Suzana Žunec, Rakesh K. Sit, Zoran Radić, K. Barry Sharpless, Zrinka Kovarik
Publikováno v:
The Journal of pharmacology and experimental therapeutics, vol 367, iss 2
In the development of antidotal therapy for treatment of organophosphate exposure from pesticides used in agriculture and nerve agents insidiously employed in terrorism, the alkylpyridinium aldoximes have received primary attention since their early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5fc445126ee04fd983d35211ecaac1
https://doi.org/10.1124/jpet.118.249383
https://doi.org/10.1124/jpet.118.249383
Autor:
William C. Hou, K. Barry Sharpless, Shyong Yan-Jye, Zoran Radić, Gisela Andrea Camacho-Hernandez, Palmer Taylor, Zrinka Kovarik, Yvonne J. Rosenberg, Jeremiah D. Momper, Rakesh K. Sit
Publikováno v:
Chemico-biological interactions. 308
Since the development in the 1950's of 2-PAM (Pralidoxime), an antidote that reactivates organophosphate conjugated acetylcholinesterase in target tissues upon pesticide or nerve agent exposure, improvements in antidotal therapy have largely involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180d48412df8c09ffa0ba2276f38fb0f
https://pubmed.ncbi.nlm.nih.gov/31100277
https://pubmed.ncbi.nlm.nih.gov/31100277
Autor:
K. Barry Sharpless, Nikolina Maček Hrvat, Palmer Taylor, Zoran Radić, Valery V. Fokin, Rakesh K. Sit, Maja Katalinić, Jaroslaw Kalisiak, Zrinka Kovarik, Tamara Zorbaz
Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Currently used therapy in counteracting excessive cholinergic stimulation consists o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02802094b3bc5269f6389b65566438fe
https://www.bib.irb.hr/994871
https://www.bib.irb.hr/994871
Autor:
Zoran Radić, K. Barry Sharpless, Nathan Samskey, Palmer Taylor, Rakesh K. Sit, Kwok-Yiu Ho, Jeremiah D. Momper
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::953a995857a784336b824172d318ee40
https://doi.org/10.1096/fasebj.2020.34.s1.06319
https://doi.org/10.1096/fasebj.2020.34.s1.06319
Autor:
Zoran Radić, Rakesh K. Sit, Gabriel Amitai, K. Barry Sharpless, Palmer Taylor, Valery V. Fokin
Publikováno v:
Journal of medicinal chemistry, vol 57, iss 4
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by efficient, quickly deployable countermeasures such as antidotes reactivating acetylcholinesterase or scavenging the parent OP. We present here synthesis and initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a260055edf150eeb4af4b1271ac65ff
https://doi.org/10.1021/jm401650z
https://doi.org/10.1021/jm401650z
Publikováno v:
Journal of the American Chemical Society. 136:195-202
Rhodium(II) azavinyl carbenes, conveniently generated from 1-sulfonyl-1,2,3-triazoles, undergo a facile, mild, and convergent formal 1,3-insertion into N-H and O-H bonds of primary and secondary amides, various alcohols, and carboxylic acids to affor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812ac52a5614a1198132f9bf651ee089
https://doi.org/10.1021/ja408185c
https://doi.org/10.1021/ja408185c
Autor:
Zoran Radić, Palmer Taylor, Valery V. Fokin, Limin Zhang, Suzana Berend, Gabriel Amitai, K. Barry Sharpless, Edzna Garcia, Rakesh K. Sit, Zrinka Kovarik
Publikováno v:
Chemico-Biological Interactions. 203:67-71
A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. N-substituted 2-hydroxyiminoacet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26672827f8efd721970eb87bd70c2fd
https://doi.org/10.1016/j.cbi.2012.08.014
https://doi.org/10.1016/j.cbi.2012.08.014
Autor:
Palmer Taylor, Valery V. Fokin, Rakesh K. Sit, Zrinka Kovarik, Zoran Radić, Suzana Žunec, Alexander Paradyse, Maja Katalinić, Kamil Musilek, Nikolina Maček Hrvat
Publikováno v:
Chemical research in toxicology, vol 28, iss 5
Exposure to the nerve agent soman is difficult to treat due to the rapid dealkylation of soman-acetylcholinesterase (AChE) conjugate known as aging. Oxime antidotes commonly used to reactivate organophosphate inhibited AChE are ineffective against so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf0efaf78faeb91e3468e5b02a4fe6e
https://europepmc.org/articles/PMC4791098/
https://europepmc.org/articles/PMC4791098/
Publikováno v:
ChemInform. 46
(Cyclopentadienyl)(cyclooctadiene) ruthenium(II) chloride [CpRuCl(cod)] catalyzes the reaction between nitrile oxides and electronically deficient 1-choro-, 1-bromo-, and 1-iodoalkynes leading to 4-haloisoxazoles. Organic azides are also suitable 1,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c6fcb3e66908c74e982d2f92dcc6b07
https://doi.org/10.1002/chin.201509028
https://doi.org/10.1002/chin.201509028