Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rakesh K. Singhal"'
Autor:
Ranjan Mittal, Mayanak K. Gupta, Sanjay K. Mishra, Sourabh Wajhal, Peram D. Babu, Manoj Mohapatra, Baltej Singh, Anil Bhimrao Shinde, Poluri Siva Rama Krishna, R. M. Kadam, Rakesh K. Singhal, Rakesh Ranjan, Samrath Lal Chaplot
Publikováno v:
Physical Review B. 105
Autor:
Kuang-Hua Chen, Deepak K. Srivastava, Sam Jacob, Rakesh K. Singhal, Samuel H. Wilson, Ahmed E. Ahmed
Publikováno v:
Carcinogenesis. 21:1017-1022
In the present study, we found that oxidized low density lipoprotein, but not low density lipoprotein, down-regulated base excision repair activity in extracts of mouse monocyte cell line PU5-1.8. An enzyme required in this pathway, DNA polymerase be
Autor:
Rakesh K. Singhal, Ajey Jain
Publikováno v:
Neonatology. 77:261-266
Human premature neonates suffer from respiratory distress syndrome due to immature lungs and require assisted ventilation with high concentrations of oxygen. Hyperoxic exposure and/or antioxidant deficiency causes an increase in the lung levels of re
Autor:
Julie K. Horton, F. Michael Yakes, Kuang-Hua Chen, Robert W. Sobol, Deepak Srivastava, Rakesh K. Singhal, Bennett Van Houten, Samuel H. Wilson
Publikováno v:
Nucleic Acids Research. 26:2001-2007
DNA polymerase beta is required in mammalian cells for the predominant pathway of base excision repair involving single nucleotide gap filling DNA synthesis. Here we examine the relationship between oxidative stress, cellular levels of DNA polymerase
Publikováno v:
Journal of Biological Chemistry. 270:949-957
The G:U mismatch in genomic DNA mainly arises from deamination of cytosine residues and is repaired by the base excision repair pathway. We found that a bovine testis crude nuclear extract conducts uracil-initiated base excision repair in vitro. A 51
Autor:
Rakesh K. Singhal, Samuel H. Wilson
Publikováno v:
Journal of Biological Chemistry. 268:15906-15911
Mammalian DNA polymerase beta (beta-pol) is considered to be part of the DNA repair machinery. However, there have been conceptual problems with this idea because beta-pol does not completely fill some gapped substrates, and unlike other DNA polymera
Autor:
Louise Prakash, Steven G. Widen, John F. Watkins, Samuel H. Wilson, Rakesh K. Singhal, Rajendra Prasad
Publikováno v:
Nucleic Acids Research. 21:5301-5307
We have shown by activity gel that overexpression in E. coli of a yeast chromosome 3 open reading frame (ORF) designated YCR14C and bearing homology to mammalian DNA polymerases beta results in a new DNA polymerase in the host cells. The molecular ma
Publikováno v:
Molecular and General Genetics MGG. 236:17-24
We measured the relative steady-state levels of the mRNA transcribed from the Saccharomyces cerevisiae REV3 gene in cells at different stages of the mitotic and meiotic cycles, and after UV irradiation. This gene is thought to encode a DNA polymerase
Autor:
Ralf Kühn, Samuel H. Wilson, Klaus Rajewsky, Rajendra Prasad, Hua Gu, Julie K. Horton, Rakesh K. Singhal, Robert W. Sobol
Publikováno v:
Nature. 379(6561)
Synthesis of DNA by DNA polymerase-beta is distributive on single-stranded DNA templates, but short DNA gaps with a 5' PO4 in the gap are filled processively to completion. In vitro studies have suggested a role of beta-polymerase in different types
Autor:
Jeffrey M. Besterman, Bradley Morton, William A. Beard, Rakesh K. Singhal, Samuel H. Wilson, Rajendra Prasad, Intisar Husain
DNA polymerase beta (beta-polymerase) has been implicated in short-patch DNA synthesis in the DNA repair pathway known as base excision repair. The native 39 kDa enzyme is organized into four structurally and functionally distinct domains. In an effo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a147a55cd72631fa7440d5c410e12d
https://europepmc.org/articles/PMC306903/
https://europepmc.org/articles/PMC306903/