Výsledky vyhledávání - "Rakesh H Basavalingappa"

Akademický článek

Mutations in the 5' NTR and the Non-Structural Protein 3A of the Coxsackievirus B3 Selectively Attenuate Myocarditogenicity.

Autor: Chandirasegaran Massilamany, Arunakumar Gangaplara, Rakesh H Basavalingappa, Rajkumar A Rajasekaran, Hiep Vu, Jean-Jack Riethoven, David Steffen, Asit K Pattnaik, Jay Reddy

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0131052 (2015)

The 5' non-translated region (NTR) is an important molecular determinant that controls replication and virulence of coxsackievirus B (CVB)3. Previous studies have reported many nucleotide (nt) sequence differences in the Nancy strain of the virus, in

Externí odkaz: https://doaj.org/article/a8d6e28d981e4385891f3ac703591314

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Akademický článek

Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis

Autor: Ninaad Lasrado, Arunakumar Gangaplara, Chandirasegaran Massilamany, Rajkumar Arumugam, Allison Shelbourn, Mahima T. Rasquinha, Rakesh H. Basavalingappa, Gustavo Delhon, Shi-Hua Xiang, Asit K. Pattnaik, David Steffen, Jay Reddy

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)

Abstract Coxsackievirus B3 (CVB3), is commonly implicated in myocarditis, which can lead to dilated cardiomyopathy, in addition to causing acute pancreatitis and meningitis. Yet, no vaccines are currently available to prevent this infection. Here, we

Externí odkaz: https://doaj.org/article/a4c70442348c476e871597050323e742

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Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis

Autor: Mahima T. Rasquinha, Asit K. Pattnaik, David J. Steffen, Chandirasegaran Massilamany, Rajkumar Arumugam, Shi Hua Xiang, Rakesh H. Basavalingappa, G. Delhon, Ninaad Lasrado, Arunakumar Gangaplara, Allison Shelbourn, Jay Reddy

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports

Coxsackievirus B3 (CVB3), is commonly implicated in myocarditis, which can lead to dilated cardiomyopathy, in addition to causing acute pancreatitis and meningitis. Yet, no vaccines are currently available to prevent this infection. Here, we describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060fa9b65b676b8240b49cc6b1dd3ca5
https://doaj.org/article/a4c70442348c476e871597050323e742

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Viral myocarditis involves the generation of autoreactive T cells with multiple antigen specificities that localize in lymphoid and non-lymphoid organs in the mouse model of CVB3 infection

Autor: Rakesh H. Basavalingappa, Chandirasegaran Massilamany, Rajkumar Arumugam, Arunakumar Gangaplara, David J. Steffen, Shi Hua Xiang, Jean-Jack M Riethoven, Jay Reddy, Ninaad Lasrado, Bharathi Yalaka

Publikováno v: Mol Immunol

Autoreactive T cells may contribute to post-viral myocarditis induced with Coxsackievirus B3 (CVB3), but the underlying mechanisms of their generation are unclear. Here, we have comprehensively analyzed the generation of antigen-specific, autoreactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea24953111755fe19a326a04e8700e81
https://europepmc.org/articles/PMC7363587/

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Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A/J Mice

Autor: Muhammad Afzal, Chandirasegaran Massilamany, Rajkumar A. Rajasekaran, Arunakumar Gangaplara, Paras Kumar Mishra, Raymond A. Sobel, Rakesh H. Basavalingappa, David J. Steffen, Vahid Khalilzad-Sharghi, Shyam Sundar Nandi, Jennifer L. Strande, Bharathi Krishnan, N R Jayagopala Reddy, You Zhou, Jean-Jack M Riethoven

Publikováno v: The Journal of Immunology. 200:523-537

Sarcoplasmic/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA)2a, a critical regulator of calcium homeostasis, is known to be decreased in heart failure. Patients with myocarditis or dilated cardiomyopathy develop autoantibodies to SERCA2a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a4e077351dc19f9eb9ab0bb0a5c9c5
https://doi.org/10.4049/jimmunol.1701090

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Branched chain α-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice

Autor: David J. Steffen, Jennifer L. Strande, Jean-Jack M Riethoven, Guobin Kang, Bharathi Krishnan, Rakesh H. Basavalingappa, N R Jayagopala Reddy, Qingsheng Li, Arunakumar Gangaplara, G. Delhon, Francisco A. Uzal, Chandirasegaran Massilamany

Publikováno v: Immunity, Inflammation and Disease. 5:421-434

Introduction Organ-specific autoimmune diseases are believed to result from immune responses generated against self-antigens specific to each organ. However, when such responses target antigens expressed promiscuously in multiple tissues, then the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afe96d3e3015da1f496ad585c47915dc
https://doi.org/10.1002/iid3.177

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Identification of an Epitope from Adenine Nucleotide Translocator 1 That Induces Inflammation in Heart in A/J Mice

Autor: Raymond A. Sobel, Zhongji Han, Vahid Khalilzad-Sharghi, Arunakumar Gangaplara, Shadi F. Othman, Guobin Kang, Chandirasegaran Massilamany, Bharathi Krishnan, Qingsheng Li, David J. Steffen, Rakesh H. Basavalingappa, N R Jayagopala Reddy, Jean-Jack M Riethoven

Publikováno v: The American Journal of Pathology. 186:3160-3175

Heart failure, a leading cause of death in humans, can emanate from myocarditis. Although most individuals with myocarditis recover spontaneously, some develop chronic dilated cardiomyopathy. Myocarditis may result from both infectious and noninfecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24559b7e9bcffa9882c27c0b63fd66a1
https://doi.org/10.1016/j.ajpath.2016.08.005

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β1-Adrenergic Receptor Contains Multiple IAk and IEk Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice

Autor: N R Jayagopala Reddy, Chandirasegaran Massilamany, Arunakumar Gangaplara, Rajkumar A. Rajasekaran, Rakesh H. Basavalingappa, Muhammad Afzal, David J. Steffen, Jean-Jack M Riethoven, Jennifer L. Strande, Bharathi Krishnan

Publikováno v: Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology

Myocarditis/dilated cardiomyopathy (DCM) patients can develop autoantibodies to various cardiac antigens and one major antigen is β1-adrenergic receptor (β1AR). Previous reports indicate that animals immunized with a β1AR fragment encompassing, 19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b5a00afc4fcb50e5f1a3a8fb37f140
http://journal.frontiersin.org/article/10.3389/fimmu.2017.01567/full

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Whole genomic sequence analysis of Bacillus infantis: defining the genetic blueprint of strain NRRL B-14911, an emerging cardiopathogenic microbe

Autor: Tanya Purvis, Akram Mohammed, Timothy P. L. Smith, John Dustin Loy, Etsuko N. Moriyama, Chandirasegaran Massilamany, Raúl G. Barletta, Bharathi Krishnan, Rakesh H. Basavalingappa, Christy M. Kelley, Chittibabu Guda, Jay Reddy

Publikováno v: BMC Genomics

Background We recently reported the identification of Bacillus sp. NRRL B-14911 that induces heart autoimmunity by generating cardiac-reactive T cells through molecular mimicry. This marine bacterium was originally isolated from the Gulf of Mexico, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d3cec31414017c66838b491bb05dec
http://europepmc.org/articles/PMC5001198

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