Výsledky vyhledávání - "Rakesh C. Sharma"

Akademický článek

Biomonitoring of genotoxic and cytotoxic effects of gingival epithelial cells exposed to digital panoramic radiography

Autor: Anuradha Pai, Rakesh C Sharma, Raghavendra Mahadev Naik, Yadavalli Guruprasad

Publikováno v: Journal of Orofacial Sciences, Vol 4, Iss 2, Pp 124-128 (2012)

Objective: The aim of this study was to evaluate genotoxic and cytotoxic effects of low level ionizing radiation used in digital panoramic radiography on gingival epithelial cells. Materials and Methods: We included 50 healthy individuals advised for

Externí odkaz: https://doaj.org/article/3bcd93acdac64d14be1f403e92aef2c7

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P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake

Autor: Eugene B. Mechetner, Rakesh C. Sharma, Robert T. Schimke, David de Graaf, Igor B. Roninson

Publikováno v: Proceedings of the National Academy of Sciences. 93:1238-1242

P-glycoprotein (Pgp), a transmembrane efflux pump encoded by the MDR1 gene, transports various lipophilic drugs that enter the cell by passive diffusion through the lipid bilayer. Pgp-expressing multidrug-resistant cell lines are not usually cross-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8a6fb9b9189115de7113f4bcabb074
https://doi.org/10.1073/pnas.93.3.1238

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Life, death and genomic change in perturbed cell cycles

Autor: Rakesh C. Sharma, Steven S. Sherwood, Robert T. Schimke, Andrew L. Kung, Jamie Sheridan

Publikováno v: Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 345:311-317

HeLaS3 cells undergo apoptosis after 18-24 h of cell cycle stasis irrespective of the agent employed (colcemid, aphidicolin, cis-platin). At high drug concentrations apoptosis occurs in cells arrested in the cell cycle in which the drug is applied an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25a48c4a54c7f7f6eec8376db5b288c
https://doi.org/10.1098/rstb.1994.0111

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Biomonitoring of genotoxic and cytotoxic effects of gingival epithelial cells exposed to digital panoramic radiography

Autor: Raghavendra Mahadev Naik, Anuradha Pai, Rakesh C Sharma, Yadavalli Guruprasad

Publikováno v: Journal of Orofacial Sciences, Vol 4, Iss 2, Pp 124-128 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56550b5a7e0d64c7c10d09671c7d3b7b
https://doi.org/10.4103/0975-8844.106207

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The propensity for gene amplification: a comparison of protocols, cell lines, and selection agents

Autor: Rakesh C. Sharma, Robert T. Schimke

Publikováno v: Mutation research. 304(2)

We have studied cell lines of rodent and human origin for their propensity to become resistant to antifolates (methotrexate, trimetrexate), phosphonacetyl- L -aspartate (PALA), and colcemid, resistances associated with amplification of the DHFR, CAD,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdaedec6c4105b7e32b2bdc1887169f3
https://pubmed.ncbi.nlm.nih.gov/7506368

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Repair of DNA double-strand breaks in UV-irradiated Escherichia coli uvrB recF cells is inhibited by rich growth medium

Autor: Rakesh C. Sharma, Kendric C. Smith

Publikováno v: Mutation Research/DNA Repair Reports. 166:23-28

Ultraviolet (UV)-irradiated uvrB recF and uvrB recB cells of Escherichia coli K-12 showed similar radiation sensitivities when plated on minimal growth medium (MM), however, the uvrB recF cells were much more UV radiation-sensitive than the uvrB recB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e060cc23a66b034613b8f8eaa712394
https://doi.org/10.1016/0167-8817(86)90037-4

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Comparison of the rep-38 and mmrA1 mutations of Escherichia coli

Autor: Rakesh C. Sharma, Kendric C. Smith

Publikováno v: Mutation Research/DNA Repair Reports. 184:23-28

The rep-38 and mmrA1 mutations are located very close to each other (approximately 85 min), and have been suggested to be allelic. To address this question we have compared the phenotypes of the mmrA1 and rep-38 mutants. Both the mmrA1 and rep-38 mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060a25bdc7af6a6251b423bb7a130877
https://doi.org/10.1016/0167-8817(87)90032-0

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recA-Dependent DNA repair in UV-irradiated Escherichia coli

Autor: Rakesh C. Sharma, Kendric C. Smith, Tzu-chien V. Wang

Publikováno v: Journal of Photochemistry and Photobiology B: Biology. 1:1-11

UV-radiation-induced lesions in DNA result in the formation of excision gaps, daughter-strand gaps (DSG) and double-strand breaks (DSB), which are repaired by several different mechanisms. Postreplication repair. The recA gene is a master gene that c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e540d593f483cd5d3101c5848911a603
https://doi.org/10.1016/1011-1344(87)80002-7

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Role of DNA polymerase I in postreplication repair: a reexamination with Escherichia coli delta polA

Autor: Rakesh C. Sharma, Kendric C. Smith

Publikováno v: Journal of Bacteriology. 169:4559-4564

Using strains of Escherichia coli K-12 that are deleted for the polA gene, we have reexamined the role of DNA polymerase I (encoded by polA) in postreplication repair after UV irradiation. The polA deletion (in contrast to the polA1 mutation) made uv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7601b4c88aa334b1f32f4214b3721c40
https://doi.org/10.1128/jb.169.10.4559-4564.1987

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