Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Rakesh C Kukreja"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86977 (2014)
BackgroundIt has been well documented that phosphodiesterase-5 inhibitor, sildenafil (SIL) protects against myocardial ischemia/reperfusion (I-R) injury. SIRT1 is part of the class III Sirtuin family of histone deacetylases that deacetylates proteins
Externí odkaz:
https://doaj.org/article/05908ba017504837bc2a445f15aac99f
Autor:
Aditi R Chiplunkar, Tina K Lung, Yousef Alhashem, Benjamin A Koppenhaver, Fadi N Salloum, Rakesh C Kukreja, Jack L Haar, Joyce A Lloyd
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54891 (2013)
Krüppel-like factor 2 (KLF2) is expressed in endothelial cells in the developing heart, particularly in areas of high shear stress, such as the atrioventricular (AV) canal. KLF2 ablation leads to myocardial thinning, high output cardiac failure and
Externí odkaz:
https://doaj.org/article/0280dc82b8e54499a3c035d168c1fc01
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45243 (2012)
Insulin resistance impairs nitric oxide (NO) bioavailability and obesity promotes a state of chronic inflammation and damages the vascular endothelium. Phosphodiesterase-5 inhibitors restore NO signaling and may reduce circulating inflammatory marker
Externí odkaz:
https://doaj.org/article/046a3a5f3a7e4109b786d51d16a18209
Autor:
Arun Samidurai, Amy L. Olex, Ramzi Ockaili, Donatas Kraskauskas, Sean K. Roh, Rakesh C. Kukreja, Anindita Das
Publikováno v:
Cells, Vol 12, Iss 24, p 2820 (2023)
The inhibition of mammalian target of rapamycin (mTOR) with rapamycin (RAPA) provides protection against myocardial ischemia/reperfusion (I/R) injury in diabetes. Since interactions between transcripts, including long non-coding RNA (lncRNA), microRN
Externí odkaz:
https://doaj.org/article/ea3dba0734e04220a1b093176baaa78c
Autor:
Arun Samidurai, Manu Saravanan, Ramzi Ockaili, Donatas Kraskauskas, Suet Ying Valerie Lau, Varun Kodali, Shakthi Ramasamy, Karthikeya Bhoopathi, Megha Nair, Sean K. Roh, Rakesh C. Kukreja, Anindita Das
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8998 (2023)
Robust activation of mTOR (mammalian target of rapamycin) signaling in diabetes exacerbates myocardial injury following lethal ischemia due to accelerated cardiomyocyte death with cardiac remodeling and inflammatory responses. We examined the effect
Externí odkaz:
https://doaj.org/article/3141f2b2e68e4777964116122d270bb2
Autor:
Arun Samidurai, Ramzi Ockaili, Chad Cain, Sean K. Roh, Scott M. Filippone, Donatas Kraskauskas, Rakesh C. Kukreja, Anindita Das
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100772- (2021)
Summary: We developed a preclinical model of myocardial ischemia/reperfusion (I/R) injury in conscious diabetic rabbits to identify an early pharmacological intervention for patients with diabetes and acute myocardial infarction (AMI). Here, we descr
Externí odkaz:
https://doaj.org/article/642679fac5a64166858590707e2f0445
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 324:R589-R600
Androgen-deprivation therapy (ADT) is the primary systemic therapy for treating advanced or metastatic prostate cancer (PCa), which has improved survival outcomes in patients with PCa. However, ADT may develop metabolic and cardiovascular adverse eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17cedab7bea97ec3a13142642f2d3d08
https://doi.org/10.1152/ajpregu.00259.2022
https://doi.org/10.1152/ajpregu.00259.2022
Autor:
Arun Samidurai, Ramzi Ockaili, Chad Cain, Sean K. Roh, Scott M. Filippone, Donatas Kraskauskas, Rakesh C. Kukreja, Anindita Das
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101863- (2020)
Summary: Persistent activation of mTOR (mammalian target of rapamycin) in diabetes increases the vulnerability of the heart to ischemia/reperfusion (I/R) injury. We show here that infusion of rapamycin (mTOR inhibitor) at reperfusion following ischem
Externí odkaz:
https://doaj.org/article/d42412406e6f4485a07fdde4d4b0c978
Publikováno v:
Pharmaceuticals, Vol 13, Iss 12, p 450 (2020)
Doxorubicin (Dox)-induced muscle toxicity (DIMT) is a common occurrence in cancer patients; however, the cause of its development and progression is not established. We tested whether inflammation-triggered cell death, “pyroptosis” plays a role i
Externí odkaz:
https://doaj.org/article/ae91a2d4fbe24a57b998209d1f2f84b7
Autor:
Chunmeng Zhang, Pranita Atri, Palanisamy Nallasamy, Seema Parte, Sanchita Rauth, Rama Krishna Nimmakayala, Saravanakumar Marimuthu, Ramakanth Chirravuri-Venkata, Rakesh Bhatia, Sushanta Halder, Ashu Shah, Jesse L. Cox, Lynette Smith, Sushil Kumar, Jason M. Foster, Rakesh C. Kukreja, Parthasarathy Seshacharyulu, Moorthy P. Ponnusamy, Surinder K. Batra
Publikováno v:
Cancer letters. 551
Mucin MUC4 is an aberrantly expressed oncogene in pancreatic ductal adenocarcinoma (PDAC), yet no pharmacological inhibitors have been identified to target MUC4. Here, we adapted an in silico screening method using the Cancer Therapeutic Response Dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d62dda2508cf7eb8d11c85a3263ecff
https://pubmed.ncbi.nlm.nih.gov/36285687
https://pubmed.ncbi.nlm.nih.gov/36285687