Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rakesh, Chibber"'
Publikováno v:
Journal of Ophthalmology, Vol 2010 (2010)
Objectives. Using apocynin (inhibitor of NADPH oxidase), and Mitoquinol 10 nitrate (MitoQ; mitochondrial-targeted antioxidant), we addressed the importance of mitochondria versus NADPH oxidase-derived ROS in glucose-induced apoptosis of pericytes. Me
Externí odkaz:
https://doaj.org/article/5599fdc763e14c41871bc5c80df8a6fe
Publikováno v:
Expert review of endocrinologymetabolism. 2(5)
Despite marked improvements in the treatment of diabetes and its retinal complications, diabetic retinopathy remains a leading cause of blindness and vision impairment in working-age adults. Control of blood glucose and blood pressure will remain imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85b9b04f854c0f7ca9c9e5228044b45
https://pubmed.ncbi.nlm.nih.gov/30736125
https://pubmed.ncbi.nlm.nih.gov/30736125
Autor:
Rakesh Chibber, Mohit Chopra, Eva M. Kohner, Ruhul Choudhury, Joanna M. Tarr, Thomas Phillip Ellis, Kirti Kaul
Publikováno v:
Current Diabetes Reviews. 9:146-160
Diabetic retinopathy (DR) is the leading cause of blindness amongst the working-age population, and diabetes accelerated cardiovascular disease (CVD) the commonest cause of death in diabetic patients. Although, there is evidence suggesting a close as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9d6be6b1271a06d211b498243378b9
https://doi.org/10.2174/157339913805076481
https://doi.org/10.2174/157339913805076481
Publikováno v:
Cellular Signalling. 24:873-878
Increasing evidence suggests that chronic, sub-clinical inflammation plays an important role in the pathogenesis of diabetic retinopathy. We have established the potential role of the inflammatory enzyme, core 2 β-1, 6-N-acetylglucosaminyltransferas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fc69de9ae70671edfa03aabb2e1f77
https://doi.org/10.1016/j.cellsig.2011.12.003
https://doi.org/10.1016/j.cellsig.2011.12.003
Publikováno v:
Current Diabetes Reviews. 3:3-14
Diabetic retinopathy is one of the most common diabetic complications, and is a major cause of new blindness in the working-age population of developed countries. Progression of vascular abnormalities, including the selective loss of pericytes, forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d29c2f09d9a806f33cb13e4cd032f5
https://doi.org/10.2174/157339907779802139
https://doi.org/10.2174/157339907779802139
Autor:
Bahaedin M. Ben-Mahmud, Alessandro Datti, Aldo Orlacchio, R M Abdulahad, Eva M. Kohner, Rakesh Chibber, W H Chan
Publikováno v:
Diabetologia. 49:2185-2191
Increasing evidence suggests that chronic, subclinical inflammation plays an important role in the pathogenesis of diabetic retinopathy. We recently reported that a glycosylating enzyme, core 2 beta-1,6-N-acetylglucosaminyltransferase (core 2 GlcNAc-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b3d82cbb4d4a6336e40a51c8abceb8
https://doi.org/10.1007/s00125-006-0332-2
https://doi.org/10.1007/s00125-006-0332-2
Autor:
Ay Lin Kho, Patrick J. Pagano, Min Zhang, Rakesh Chibber, Narayana Anilkumar, Alison C. Cave, Ajay M. Shah
Publikováno v:
Circulation. 113:1235-1243
Background— Nonenzymatic glycation that results in the production of early-glycation Amadori-modified proteins and advanced-glycation end products may be important in the pathogenesis of diabetic complications. However, the effects of early-glycate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfc819626eb5695aff357b31266a8b7
https://doi.org/10.1161/circulationaha.105.581397
https://doi.org/10.1161/circulationaha.105.581397
Publikováno v:
Diabetes. 49:1724-1730
The exact mechanism for capillary occlusion in diabetic retinopathy is still unclear, but increased leukocyte-endothelial cell adhesion has been implicated. We examined the possibility that posttranslational modification of surface O-glycans by incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef00784563925359aa9eaf8b94894b7
https://doi.org/10.2337/diabetes.49.10.1724
https://doi.org/10.2337/diabetes.49.10.1724
Publikováno v:
Advances in experimental medicine and biology. 771
With the incidence, and prevalence of diabetes mellitus increasing worldwide, diabetic retinopathy is expected to reach epidemic proportions. The aim of this chapter is to introduce diabetic retinopathy, a leading cause of blindness in people of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72833061f52c51fa5150ac1f9b236769
https://pubmed.ncbi.nlm.nih.gov/23393674
https://pubmed.ncbi.nlm.nih.gov/23393674
Publikováno v:
Advances in experimental medicine and biology. 771
The chronic metabolic disorder diabetes mellitus is a fast-growing global problem with huge social, health, and economic consequences. It is estimated that in 2010 there were globally 285 million people (approximately 6.4% of the adult population) su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ca157a2a557493d0a56abd2924cf7ae
https://pubmed.ncbi.nlm.nih.gov/23393665
https://pubmed.ncbi.nlm.nih.gov/23393665