Discovery of new anti-diabetic potential agents based on paracetamol incorporating sulfa-drugs: Design, synthesis, α-amylase, and α-glucosidase inhibitors with molecular docking simulation.

Autor: Khamees Thabet H; Department of Chemistry, College of Sciences and Arts, Northern Border University, Rafha, 91911, Saudi Arabia., Ragab A; Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt. Electronic address: ahmed_ragab7@ymail.com., Imran M; Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha, 91911, Saudi Arabia., Helal MH; Department of Chemistry, College of Sciences and Arts, Northern Border University, Rafha, 91911, Saudi Arabia., Ibrahim Alaqel S; Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha, 91911, Saudi Arabia., Alshehri A; Department of Pharmacology and Toxicology, College of Pharmacy, Northern Border University, Rafha, 91911, Saudi Arabia; Department of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, King Faisal Road, Dammam, 31441, Saudi Arabia., Ash Mohd A; Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha, 91911, Saudi Arabia., Rakan Alshammari M; Department of Chemistry, College of Sciences and Arts, Northern Border University, Rafha, 91911, Saudi Arabia., S Abusaif M; Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt., A Ammar Y; Department of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116589. Date of Electronic Publication: 2024 Jun 08.