Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rakan Albalawy"'
Publikováno v:
Cells, Vol 13, Iss 16, p 1309 (2024)
Perivascular adipose tissue (PVAT) is a special deposit of fat tissue surrounding the vasculature. Previous studies suggest that PVAT modulates the vasculature function in physiological conditions and is implicated in the pathogenesis of vascular dis
Externí odkaz:
https://doaj.org/article/bcd7c3a3e17c4e6182d8e0a60e060473
Autor:
Salma El-Behaedi, Rebekah Landsman, Michael Rudloff, Emily Kolyvas, Rakan Albalawy, Xianyu Zhang, Tapan Bera, Keith Collins, Serguei Kozlov, Christine Alewine
Publikováno v:
Toxins, Vol 10, Iss 11, p 447 (2018)
LMB-100 is a mesothelin-targeted recombinant immunotoxin (iTox) that carries a modified Pseuodomonas exotoxin A (PE) payload. PE kills cells by inhibiting synthesis of new proteins. We found that treatment of pancreatic cancer cells with LMB-100 for
Externí odkaz:
https://doaj.org/article/e47a4c7aef404df6a5836a10122e6bf1
Autor:
Christine Alewine, Xianyu Zhang, Xiongfong Chen, Rakan Albalawy, Danielle Arons, Salma El-Behaedi, Michael Rudloff, Leela Rani Avula
MSLN sequence showing positioning of the Exon 3 gRNA site.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9c0797a7681ffefe695c340c1f1b64
https://doi.org/10.1158/1541-7786.22517997
https://doi.org/10.1158/1541-7786.22517997
Autor:
Christine Alewine, Xianyu Zhang, Xiongfong Chen, Rakan Albalawy, Danielle Arons, Salma El-Behaedi, Michael Rudloff, Leela Rani Avula
Figure Legends and Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1faac0ba5a245982ae903589fc46ba99
https://doi.org/10.1158/1541-7786.22517979.v1
https://doi.org/10.1158/1541-7786.22517979.v1
Autor:
John Nemunaitis, Monika Devanaboyina, Nealie Ngo, Rakan Albalawy, Louis Filipiak, Hannah Staats, Laura Stanbery, Danae Hamouda
Publikováno v:
Clinical Oncology and Research. :1-13
Angiogenesis plays an important role in tumor growth. Established vasculature provides a supply of nutrients and other necessary survival factors for tumor cell maintenance. In addition, immune factors with capacity to both decrease immune activity l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::231d902e7a64f104e9a2b04997a8fb5e
https://doi.org/10.31487/j.cor.2021.02.01
https://doi.org/10.31487/j.cor.2021.02.01
Autor:
Xianyu Zhang, Xiongfong Chen, Michael Rudloff, Christine Alewine, Danielle Arons, Rakan Albalawy, Salma El-Behaedi, Leela Rani Avula
Publikováno v:
Mol Cancer Res
Over 90% of pancreatic ductal adenocarcinomas (PDAC) express mesothelin (MSLN). Overexpression or knockdown of MSLN has been implicated in PDAC aggressiveness. This activity has been ascribed to MSLN-induced activation of MAPK or NF-κB signaling pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f05f605f42ca53a6817130c15baee2
https://doi.org/10.1158/1541-7786.mcr-19-0688
https://doi.org/10.1158/1541-7786.mcr-19-0688
Publikováno v:
Blood. 136:9-10
Paroxysmal Nocturnal Hemoglobinuria (PNH) is an acquired hemolytic disorder of the multipotent myeloid stem cells, due to underexpression of surface complement inhibitory proteins CD55 and CD59, affecting 0.13/100,000 patients per year. Besides anemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c7aa724d04aabfa6ec22586740ef68c
https://doi.org/10.1182/blood-2020-141501
https://doi.org/10.1182/blood-2020-141501
Autor:
Susan Morand, Laura Stanbery, John J. Nemunaitis, Mary T Albrethsen, Rayna Patel, Michael Nemunaitis, Rakan Albalawy, Adam Walter, Khalil Choucair, F. Charles Brunicardi, Lance D. Dworkin, Leslie L Lin
Publikováno v:
Genetics & Molecular Medicine. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fd0d03e945b3a4fd5144fc057626ccb
https://doi.org/10.33425/2689-1077.1004
https://doi.org/10.33425/2689-1077.1004
Autor:
Serguei Kozlov, Salma El-Behaedi, Emily Kolyvas, Rebekah Landsman, Xianyu Zhang, Christine Alewine, Rakan Albalawy, Keith Collins, Tapan K. Bera, Michael Rudloff
Publikováno v:
Toxins
Volume 10
Issue 11
Toxins, Vol 10, Iss 11, p 447 (2018)
Volume 10
Issue 11
Toxins, Vol 10, Iss 11, p 447 (2018)
LMB-100 is a mesothelin-targeted recombinant immunotoxin (iTox) that carries a modified Pseuodomonas exotoxin A (PE) payload. PE kills cells by inhibiting synthesis of new proteins. We found that treatment of pancreatic cancer cells with LMB-100 for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b47e5acbe53f345211aac112c0ac8bd
Autor:
Christine Alewine, Emily Kolyvas, Rebekah Landsman, Michael Rudloff, Rakan Albalawy, Salma El-Behaedi
Publikováno v:
Cancer Research. 78:3964-3964
Recombinant immunotoxins are antibody-based therapies that carry a bacterial toxin payload. LMB-100 is a next generation immunotoxin currently being tested in clinical trial. It targets the human cell surface antigen mesothelin (MSLN). MSLN is made b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ffdf78d97375a5ac22496729dc3046
https://doi.org/10.1158/1538-7445.am2018-3964
https://doi.org/10.1158/1538-7445.am2018-3964