Výsledky vyhledávání - "Rajwinder Lehal"

Akademický článek

CB‐103: A novel CSL‐NICD inhibitor for the treatment of NOTCH‐driven T‐cell acute lymphoblastic leukemia: A case report of complete clinical response in a patient with relapsed and refractory T‐ALL

Autor: Michael Medinger, Till Junker, Dominik Heim, Alexandar Tzankov, Philip M. Jermann, Maria Bobadilla, Michele Vigolo, Rajwinder Lehal, Florian D. Vogl, Michael Bauer, Jakob Passweg

Publikováno v: eJHaem, Vol 3, Iss 3, Pp 1009-1012 (2022)

Abstract Relapsed T cell acute lymphoblastic leukaemia (T‐ALL) has a very poor prognosis. A 24‐year‐old patient with relapsed high‐risk T‐ALL (PTEN gene deletion; NOTCH1 mutation), was treated with the NOTCH inhibitor CB‐103. Within 1 wee

Externí odkaz: https://doaj.org/article/06e153db5bae43668267f8a8964d3c11

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Akademický článek

Notch Inhibition in Cancer: Challenges and Opportunities

Autor: Doriano Fabbro, Michael Bauer, Maximilien Murone, Rajwinder Lehal

Publikováno v: CHIMIA, Vol 74, Iss 10, Pp 779-783 (2020)

Notch is a key oncogenic pathway in several human cancers and to date, no targeted treatment of Notch activated cancers is available to patients. Therapeutic targeting of Notch has been an unresolved challenge due to severe on-target dose limiting to

Externí odkaz: https://doaj.org/article/3819edb6ff744a82a09d48d63474f2ab

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Akademický článek

Very High Throughput Electrical Cell Lysis and Extraction of Intracellular Compounds Using 3D Carbon Electrodes in Lab-on-a-Chip Devices

Autor: Philippe Renaud, Freddy Radtke, Rajwinder Lehal, Rodrigo Martinez-Duarte, Guillaume Mernier

Publikováno v: Micromachines, Vol 3, Iss 3, Pp 574-581 (2012)

Here we present an electrical lysis throughput of 600 microliters per minute at high cell density (108 yeast cells per ml) with 90% efficiency, thus improving the current common throughput of one microliter per minute. We also demonstrate the extract

Externí odkaz: https://doaj.org/article/801b266669894031b8d547ae9e18041e

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Abstract 408: Development of a first-in-class notch transcription factor inhibitor CB-103 to overcome resistance to chemotherapy and targeted therapies

Autor: Michele Vigolo, Charlotte Urech, Sebastien Lamy, Samarpan Majumder, Lucio Miele, Rajwinder Lehal

Publikováno v: Cancer Research. 82:408-408

Human cancers possess striking ability to develop resistance to Standard of Care (SoC) designed to target specific hallmarks of cancer. This capability to develop resistance is in part due to cancer cell’s ability to activate alternative pathways a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6055184aaef5ded4b06e1fa7c954b29
https://doi.org/10.1158/1538-7445.am2022-408

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Pharmacological disruption of the Notch transcription factor complex

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences, Vol. 117, No 28 (2020) pp. 16292-16301

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc1d0ae3db2c1a80d73cd4d14e7781c
https://pubmed.ncbi.nlm.nih.gov/32601208

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