Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Rajwana Jahan"'
Autor:
Allison Zarkin, Rajwana Jahan, Rajendra Uprety, Yanan Zhang, Charles McElhinny, Rodney Snyder, Elaine Gay, Gabriel Jewula, Heather Bool, Stewart D Clark, Scott Runyon
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 1024 (2021)
Activation of the neuropeptide S receptor (NPSR) system has been shown to produce anxiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse and duration of
Externí odkaz:
https://doaj.org/article/774898e303094257a56345421ce84511
Autor:
Bethany Crouse, Mariah M. Wu, Valeria Gradinati, Andrew J. Kassick, Daihyun Song, Rajwana Jahan, Saadyah Averick, Scott Runyon, Sandra D. Comer, Marco Pravetoni
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Drug-related fatal overdoses have significantly increased in the past decade due to the widespread availability of illicit fentanyl and other potent synthetic opioids such as carfentanil. Deliberate or accidental consumption or expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ca0f7202452fc21bffc599fe5d5441
https://doi.org/10.1021/acsptsci.1c00260
https://doi.org/10.1021/acsptsci.1c00260
Autor:
Carly Baehr, Christine Robinson, Andrew Kassick, Rajwana Jahan, Valeria Gradinati, Saadyah E. Averick, Scott P. Runyon, Marco Pravetoni
Publikováno v:
ACS omega. 7(19)
The ongoing public health emergency of opioid use disorders (OUD) and overdose in the United States is largely driven by fentanyl and its related analogues and has resulted in over 75 673 deaths in 2021. Immunotherapeutics such as vaccines have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621ed26d723470e4d1d6b36195839cd3
https://pubmed.ncbi.nlm.nih.gov/35601290
https://pubmed.ncbi.nlm.nih.gov/35601290
Autor:
Justas V. Rodarte, Carly Baehr, Dustin Hicks, Tyler L. Liban, Connor Weidle, Peter B. Rupert, Rajwana Jahan, Abigail Wall, Andrew T. McGuire, Roland K. Strong, Scott Runyon, Marco Pravetoni, Marie Pancera
Publikováno v:
Structure. 31:20-32.e5
Opioid-related fatal overdoses have reached epidemic proportions. Because existing treatments for opioid use disorders offer limited long-term protection, accelerating the development of newer approaches is critical. Monoclonal antibodies (mAbs) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4debf8dd8996df27c42d164ff9e81383
https://doi.org/10.1016/j.str.2022.11.008
https://doi.org/10.1016/j.str.2022.11.008
Autor:
Farjana Rashid, Xiaoming Jin, Guanguan Li, Jeffrey M. Witkin, Lalit K. Golani, Rok Cerne, Xingjie Ping, Wenhui Xiong, Jodi L. Smith, James M. Cook, Rajwana Jahan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 372:83-94
The imidizodiazepine, 5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole (KRM-II-81), is selective for α2/3-containing GABAA receptors. KRM-II-81 dampens seizure activity in rodent models with enhanced efficacy and red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e4d710274deebfbd6cfd9eda097fea3
https://doi.org/10.1124/jpet.119.260968
https://doi.org/10.1124/jpet.119.260968
Autor:
Xiaoming Jin, Jeffrey M. Witkin, Xingie Ping, Jodi L. Smith, James M. Cook, Guanguan Li, Farjana Rashid, Lalit K. Golani, Rajwana Jahan
Publikováno v:
Neurosurgery. 66:310-697
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad716f19c0e4b06a6c88d1be5b556184
https://doi.org/10.1093/neuros/nyz310_697
https://doi.org/10.1093/neuros/nyz310_697
Autor:
James K. Rowlett, Donna M. Platt, Laís F. Berro, Jemma E Cook, Guanguan Li, Daniela Rüedi-Bettschen, Rajwana Jahan, Lalit K. Golani, James M. Cook, Farjana Rashid
Publikováno v:
Alcoholism: Clinical and Experimental Research. 43:791-802
Background Previous studies have investigated α1GABAA and α5GABAA receptor mechanisms in the behavioral effects of ethanol (EtOH) in monkeys. However, genetic studies in humans and preclinical studies with mutant mice suggest a role for α2GABAA an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a593c0b6164bfa7fcf5526966342ba74
https://doi.org/10.1111/acer.14000
https://doi.org/10.1111/acer.14000
Autor:
Jodi L. Smith, Lalit K. Golani, Xiaoming Jin, James M. Cook, Yeunus Mian, Rok Cerne, Rajwana Jahan, Xingjie Ping, Dishary Sharmin, Farjana Rashid, Daniel E. Knutson, Jeffrey M. Witkin, V. V. N. Phani Babu Tiruveedhula, Guanguan Li
Publikováno v:
ACS chemical neuroscience. 11(17)
The need for improved medications for the treatment of epilepsy and chronic pain is essential. Epileptic patients typically take multiple antiseizure drugs without complete seizure freedom, and chronic pain is not fully managed with current medicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c20d352959f149e1c1a021191bab963
https://pubmed.ncbi.nlm.nih.gov/32786313
https://pubmed.ncbi.nlm.nih.gov/32786313
Publikováno v:
Synthesis (Stuttg)
An improved synthesis of the anxiolytic, anticonvulsant, and antinociceptive compounds: Hz-166, and its bioisosteres 1,2,4-oxadiazole (MP-III-080) and 1,3-oxazole (KRM-II-81) were synthesized in higher yields and with more facile purification methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600a2f9dc97cdfc4b1413b2195f9e54e
https://pubmed.ncbi.nlm.nih.gov/32773890
https://pubmed.ncbi.nlm.nih.gov/32773890
Autor:
Gloria S. Forkuo, James M. Cook, Gene T. Yocum, Revathi Kodali, Leggy A. Arnold, Rajwana Jahan, Michael Rajesh Stephen, Margaret L. Guthrie, Douglas A. Steeber, Charles W. Emala, Douglas C. Stafford, Olivia B. Yu, Guanguan Li, Nicolas M Zahn, Ted William Harris, Janet L. Fisher, Amanda N. Nieman, M S Rashid Roni
Publikováno v:
Molecular Pharmaceutics. 15:1766-1777
We describe lead compound MIDD0301 for the oral treatment of asthma based on previously developed positive allosteric α(5)β(3)γ(2) selective GABA(A) receptor (GABA(A)R) ligands. MIDD0301 relaxed airway smooth muscle at single micromolar concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b93345b08045b2b3af1122f8fda4a35
https://doi.org/10.1021/acs.molpharmaceut.7b01013
https://doi.org/10.1021/acs.molpharmaceut.7b01013