Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Rajvinder Karda"'
Autor:
Valda Pauzuolyte, Aara Patel, James R Wawrzynski, Neil J Ingham, Yeh Chwan Leong, Rajvinder Karda, Maria Bitner‐Glindzicz, Wolfgang Berger, Simon N Waddington, Karen P Steel, Jane C Sowden
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)
Abstract Deafness affects 5% of the world's population, yet there is a lack of treatments to prevent hearing loss due to genetic causes. Norrie disease is a recessive X‐linked disorder, caused by NDP gene mutation. It manifests as blindness at birt
Externí odkaz:
https://doaj.org/article/20194006b0f44e9ebc938dfeede099dc
Autor:
John R. Counsell, Guillaume De Brabandere, Rajvinder Karda, Marc Moore, Antonio Greco, Alysha Bray, Juan Antinao Diaz, Dany P. Perocheau, Ulrike Mock, Simon N. Waddington
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 357-365 (2021)
Lentiviral (LV) vectors based on human immunodeficiency virus type I (HIV-1) package two copies of their single-stranded RNA into vector particles. Normally, this RNA genome is reverse transcribed into a double-stranded DNA provirus that integrates i
Externí odkaz:
https://doaj.org/article/91dfe80765324ae6b172bc6c3bfd05e5
Autor:
Natalie Suff, Rajvinder Karda, Juan Antinao Diaz, Joanne Ng, Julien Baruteau, Dany Perocheau, Peter W. Taylor, Dagmar Alber, Suzanne M. K. Buckley, Mona Bajaj-Elliott, Simon N. Waddington, Donald Peebles
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Approximately 40% of preterm births are preceded by microbial invasion of the intrauterine space; ascent from the vagina being the most common pathway. Within the cervical canal, antimicrobial peptides and proteins (AMPs) are important components of
Externí odkaz:
https://doaj.org/article/87c4c20edc5c4f4ab1b9aa0b4309858a
Autor:
John R. Counsell, Rajvinder Karda, Juan Antinao Diaz, Louise Carey, Tatiana Wiktorowicz, Suzanne M.K. Buckley, Shima Ameri, Joanne Ng, Julien Baruteau, Filipa Almeida, Rohan de Silva, Roberto Simone, Eleonora Lugarà, Gabriele Lignani, Dirk Lindemann, Axel Rethwilm, Ahad A. Rahim, Simon N. Waddington, Steven J. Howe
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 626-634 (2018)
Viral vectors are rapidly being developed for a range of applications in research and gene therapy. Prototype foamy virus (PFV) vectors have been described for gene therapy, although their use has mainly been restricted to ex vivo stem cell modificat
Externí odkaz:
https://doaj.org/article/6238edf25cf544478737c499f40dbd36
Autor:
Julien Baruteau, Dany P. Perocheau, Joanna Hanley, Maëlle Lorvellec, Eridan Rocha-Ferreira, Rajvinder Karda, Joanne Ng, Natalie Suff, Juan Antinao Diaz, Ahad A. Rahim, Michael P. Hughes, Blerida Banushi, Helen Prunty, Mariya Hristova, Deborah A. Ridout, Alex Virasami, Simon Heales, Stewen J. Howe, Suzanne M. K. Buckley, Philippa B. Mills, Paul Gissen, Simon N. Waddington
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Patients with mutations in the ASL gene present with argininosuccinic aciduria characterised by hyperammonaemia and cognitive impairment. Here, the authors show that cerebral disease involves neuronal nitrosative/oxidative stress that is not induced
Externí odkaz:
https://doaj.org/article/bccd48b998f7466b8b4e37f6409acdb2
Autor:
Rajvinder Karda, Dany P. Perocheau, Natalie Suff, Joanne Ng, Juliette M. K. M. Delhove, Suzanne M. K. Buckley, Samantha Richards, John R. Counsell, Henrik Hagberg, Mark R. Johnson, Tristan R. McKay, Simon N. Waddington
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Luciferase bioimaging in living animals is increasingly being applied in many fields of biomedical research. Rodent imaging usually involves anaesthetising the animal during data capture, however, the biological consequences of anaesthesia h
Externí odkaz:
https://doaj.org/article/9f6f64e65ad641139897de92958624f7
Autor:
Ulrike Mock, Juan Antinao Diaz, Simon N. Waddington, Dany P. Perocheau, Marc Moore, John R. Counsell, Rajvinder Karda, Antonio Greco, Alysha Bray, Guillaume De Brabandere
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 357-365 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Lentiviral (LV) vectors based on human immunodeficiency virus type I (HIV-1) package two copies of their single-stranded RNA into vector particles. Normally, this RNA genome is reverse transcribed into a double-stranded DNA provirus that integrates i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e910a9a483f9f9766f033b6ed683bb
https://doi.org/10.1016/j.omtm.2020.12.005
https://doi.org/10.1016/j.omtm.2020.12.005
Autor:
Tristan R. McKay, Julien Baruteau, Jonathan D. Cooper, Rajvinder Karda, John R. Counsell, Els Henckaerts, Juan Antinao Diaz, Ahad A. Rahim, Simon N. Waddington, Dany P. Perocheau, Nuria Palomar Martin, Maha Tijani, Andrew Wong, Michael P. Hughes, Joanne Ng, Juliette M. K. M. Delhove, Suzanne M. K. Buckley, Natalie Suff
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Karda, R, Rahim, A A, Wong, A M S, Suff, N, Diaz, J A, Perocheau, D P, Tijani, M, Ng, J, Baruteau, J, Martin, N P, Hughes, M, Delhove, J M K M, Counsell, J R, Cooper, J D, Henckaerts, E, Mckay, T R, Buckley, S M K & Waddington, S N 2020, ' Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors ', Scientific Reports, vol. 10, no. 1, 2121 . https://doi.org/10.1038/s41598-020-59075-3
Scientific Reports
Karda, R, Rahim, A A, Wong, A M S, Suff, N, Diaz, J A, Perocheau, D P, Tijani, M, Ng, J, Baruteau, J, Martin, N P, Hughes, M, Delhove, J M K M, Counsell, J R, Cooper, J D, Henckaerts, E, Mckay, T R, Buckley, S M K & Waddington, S N 2020, ' Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors ', Scientific Reports, vol. 10, no. 1, 2121 . https://doi.org/10.1038/s41598-020-59075-3
We have previously designed a library of lentiviral vectors to generate somatic-transgenic rodents to monitor signalling pathways in diseased organs using whole-body bioluminescence imaging, in conscious, freely moving rodents. We have now expanded t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888941975b0dff8b760b0901fe7aaa79
http://link.springer.com/article/10.1038/s41598-020-59075-3
http://link.springer.com/article/10.1038/s41598-020-59075-3
Publikováno v:
Epilepsy & Behavior. 132:108741
Dravet Syndrome is a genetic epileptic syndrome characterized by severe and intractable seizures associated with cognitive, motor, and behavioral impairments. The disease is also linked with increased mortality mainly due to sudden unexpected death i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8581f974339f04aab2fd0a298174a64
https://doi.org/10.1016/j.yebeh.2022.108741
https://doi.org/10.1016/j.yebeh.2022.108741
Autor:
Michael Themis, Rajvinder Karda, Simon N. Waddington, Kuteiba Schrubaji, Saqlain Suleman, Peter Hewitson, Svetlana Ignatova, Chrysovalanto Filippou, Jonathan Huddleston
Publikováno v:
Journal of virological methods. 299
Copyright © 2021 The Author(s). Adenoviruses (AdVs) are used as gene therapy vectors to treat human diseases and as vaccines against COVID-19. AdVs are produced by transfecting human embryonic kidney 239 (HEK293) or PER.C6 virus producer cells with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a7ca4b1bad208937cd57152f24a440
https://pubmed.ncbi.nlm.nih.gov/34626684
https://pubmed.ncbi.nlm.nih.gov/34626684