Výsledky vyhledávání - "Raju S.K. Chaganti"

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34(33)

Purpose Owing to its exquisite chemotherapy sensitivity, most patients with metastatic germ cell tumors (GCTs) are cured with cisplatin-based chemotherapy. However, up to 30% of patients with advanced GCT exhibit cisplatin resistance, which requires

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34e63984bdc19562a201001302ad1b4
https://pubmed.ncbi.nlm.nih.gov/28905790

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Testicular mixed germ cell tumors: a morphological and immunohistochemical study using stem cell markers, OCT3/4, SOX2 and GDF3, with emphasis on morphologically difficult-to-classify areas

Autor: Semra Olgac, Anuradha Gopalan, Satish K. Tickoo, Jane Houldsworth, George J. Bosl, James E. Korkola, Samson W. Fine, Victor E. Reuter, Raju S.K. Chaganti, Deepti Dhall

Publikováno v: Modern Pathology. 22:1066-1074

Stem cell markers, OCT3/4, and more recently SOX2 and growth differentiation factor 3 (GDF3), have been reported to be expressed variably in germ cell tumors. We investigated the immunohistochemical expression of these markers in different testicular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c58077692c8bf9869d8072dce88eac
https://doi.org/10.1038/modpathol.2009.66

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Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression

Autor: Yao Shen, Raju S.K. Chaganti, Mukesh Bansal, Andrea Califano, Brygida Bisikirska, Julie Teruya-Feldstein

Publikováno v: Cancer research. 76(3)

Follicular lymphoma, the most common indolent subtype of non-Hodgkin lymphoma, is associated with a relatively long overall survival rate ranging from 6 to 10 years from the time of diagnosis. However, in 20% to 60% of follicular lymphoma patients, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26afacf7c48a92bb72c5883cc0a3d1c8
https://pubmed.ncbi.nlm.nih.gov/26589882

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Development and Validation of a Gene-Based Model for Outcome Prediction in Germ Cell Tumors Using a Combined Genomic and Expression Profiling Approach

Autor: Darren R. Feldman, Sandy Heck, George J. Bosl, Jane Houldsworth, Raju S.K. Chaganti, James E. Korkola, Adam B. Olshen, Victor E. Reuter

Publikováno v: PloS one, vol 10, iss 12
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0142846 (2015)

Germ Cell Tumors (GCT) have a high cure rate, but we currently lack the ability to accurately identify the small subset of patients who will die from their disease. We used a combined genomic and expression profiling approach to identify genomic regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e1ea8a5605460e71997f906aa4c2bf
https://escholarship.org/uc/item/2s21b7zx

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Biology and Genetics of Adult Male Germ Cell Tumors

Autor: George J. Bosl, James E. Korkola, Jane Houldsworth, Raju S.K. Chaganti

Publikováno v: Journal of Clinical Oncology. 24:5512-5518

Adult male germ cell tumors (GCTs) arise by transformation of totipotent germ cells. They have the unique potential to activate molecular pathways, in part mimicking those occurring during gametogenesis and normal human development, as evidenced by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5702c33a6400912df02caf2f01e618
https://doi.org/10.1200/jco.2006.08.4285

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Gene expression-based classification of nonseminomatous male germ cell tumors

Autor: Jane Houldsworth, Adam B. Olshen, Victor E. Reuter, Debbie Dobrzynski, James E. Korkola, George J. Bosl, Raju S.K. Chaganti

Publikováno v: Oncogene. 24:5101-5107

Male adult germ cell tumors (GCTs) comprise two major histologic groups: seminomas and nonseminomas. Nonseminomatous GCTs (NSGCTs) can be further divided into embryonal carcinoma (EC), teratoma (T), yolk sac tumor (YS), and choriocarcinoma (CC) on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a6bbb41378290234f7f00b6f80e516
https://doi.org/10.1038/sj.onc.1208694

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Differential Expression Patterns of c-REL Protein in Classic and Nodular Lymphocyte Predominant Hodgkin Lymphoma

Autor: Jane Houldsworth, Raju S.K. Chaganti, Daniel A. Filippa, Andrew D. Zelenetz, Qianxun Xiao, Cyrus V. Hedvat, Louis K. Sussman, Craig H. Moskowitz, Julie Teruya-Feldstein, Ning Shen

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 12:211-215

Classic Hodgkin lymphoma (cHL) is characterized by numerical gains of the short arm of chromosome 2. The high frequency of 2p overrepresentation including REL, particularly in the nodular sclerosis subtype suggests that constitutive activation of nuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65600e40dd1d48312f55afd07fd82dc8
https://doi.org/10.1097/00129039-200409000-00005

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Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas

Autor: Jing Qin, Katerina Dyomina, Yingjing Shen, Julie Teruya-Feldstein, Gerard B. Donnelly, Riccardo Dalla-Favera, Raju S.K. Chaganti, Marina Petlakh, Jane Houldsworth, Andrew D. Zelenetz, Qiulu Pan, Nallasivam Palanisamy, Adam B. Olshen, Giorgio Cattoretti

Publikováno v: Blood. 103:1862-1868

Although it has been suggested that REL is the critical target gene of 2p12-16 amplification in diffuse large B-cell lymphoma (DLBCL), little experimental evidence supports this notion. In the present study, we sought to evaluate the relationship bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7e18ec24eaee58a9e26a4ce2a87eaa
https://doi.org/10.1182/blood-2003-04-1359

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Chemotherapy for Teratoma With Malignant Transformation

Autor: Alessia Donadio, Raju S.K. Chaganti, Robert J. Motzer, Dean F. Bajorin, Joel Sheinfeld, Philip W. Kantoff, George J. Bosl, Jane Houldsworth

Publikováno v: Journal of Clinical Oncology. 21:4285-4291

Purpose: Teratoma with malignant transformation (MT) is a well-described entity that refers to the MT of a somatic teratomatous component in a germ cell tumor (GCT) to a histology that is identical to a somatic malignancy (eg, rhabdomyosarcoma [RMS])

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9161e9678af9a8372b49f36bc099c1b9
https://doi.org/10.1200/jco.2003.01.019

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Presence of somatic mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in cisplatin-resistant germ cell tumors

Autor: Darren R. Feldman, David B. Solit, George J. Bosl, Raju S.K. Chaganti, Sujata Patil, Gopa Iyer, Hikmat Al-Ahmadie, Lindsay Joy Van Alstine, Victor E. Reuter

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 20(14)

Purpose: A previous study noted frequent B-RAF mutations among European patients with cisplatin-resistant but not cisplatin-sensitive germ cell tumors (GCT). We sought to validate this finding by assessing for these mutations among patients with GCT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bcda604f509438039c869cb995c590
https://pubmed.ncbi.nlm.nih.gov/24812411

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