Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

Autor: Ruben C. Hartkoorn, Claudia Sala, João Neres, Florence Pojer, Sophie Magnet, Raju Mukherjee, Swapna Uplekar, Stefanie Boy‐Röttger, Karl‐Heinz Altmann, Stewart T. Cole

Publikováno v: EMBO Molecular Medicine, Vol 4, Iss 10, Pp 1032-1042 (2012)

Abstract Tuberculosis, a global threat to public health, is becoming untreatable due to widespread drug resistance to frontline drugs such as the InhA‐inhibitor isoniazid. Historically, by inhibiting highly vulnerable targets, natural products have

Externí odkaz: https://doaj.org/article/473ad4f4a0414534999201431e98ae15

Immunomodulatory effect of mycobacterial outer membrane vesicles coated nanoparticles

Autor: Edna George, Avijit Goswami, Tejan Lodhiya, Priyanka Padwal, Shalini Iyer, Iti Gauttam, Lakshay Sethi, Sharumathi Jeyasankar, Pallavi Raj Sharma, Ameya Atul Dravid, Raju Mukherjee, Rachit Agarwal

Tuberculosis (TB) is one of the most widely prevalent infectious diseases that cause significant mortality. Bacillus Calmette-Guérin (BCG), the current TB vaccine used in clinics, shows variable efficacy and has safety concerns for immunocompromised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d72b8cd196d92ca3f096ae8f875ae2b
https://doi.org/10.1101/2022.06.07.495204

Why are some coronavirus variants more infectious?

Autor: Rohit Satardekar, Raju Mukherjee

Publikováno v: Journal of Biosciences

Since the start of the pandemic, SARS-CoV-2 has infected almost 200 million human hosts and is set to encounter and gain entry in many more in the coming months. As the coronavirus flourish, the evolutionary pressure selects those variants that can c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cb5503992404e0ce32e9542d2be5bc
http://europepmc.org/articles/PMC8594289

Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria

Autor: Stewart T. Cole, Jérémie Piton, João Neres, John D. McKinney, Raju Mukherjee, Raphael Sommer, Wilbert Bitter, Vadim Makarov, Astrid M. van der Sar, Neeraj Dhar, Paul J. Dyson, Thierry Laroche

Publikováno v: Sommer, R, Neres, J, Piton, J, Dhar, N, van der Sar, A, Mukherjee, R, Laroche, T, Dyson, P J, McKinney, J D, Bitter, W, Makarov, V & Cole, S T 2018, ' Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria ', Acs chemical biology, vol. 13, no. 11, pp. 3184-3192 . https://doi.org/10.1021/acschembio.8b00790
Acs chemical biology, 13(11), 3184-3192. American Chemical Society
ACS chemical biology, 13(11), 3184-3192. American Chemical Society
Sommer, R, Neres, J, Piton, J, Dhar, N, van der Sar, A, Mukherjee, R, Laroche, T, Dyson, P J, McKinney, J D, Bitter, W, Makarov, V & Cole, S T 2018, ' Fluorescent Benzothiazinone Analogues Efficiently and Selectively Label Dpre1 in Mycobacteria and Actinobacteria ', ACS chemical biology, vol. 13, no. 11, pp. 3184-3192 . https://doi.org/10.1021/acschembio.8b00790

Benzothiazinones (BTZ) are highly potent bactericidal inhibitors of mycobacteria and the lead compound, BTZ043, and the optimized drug candidate, PBTZ169, have potential for the treatment of tuberculosis. Here, we exploited the tractability of the BT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4d1bbd69be8595f61a5755cd133dd3
https://doi.org/10.1021/acschembio.8b00790

Dynamics of bacterial deposition in evaporating drops

Autor: Akanksha Agrawal, Dileep Mampallil, Raju Mukherjee, Shubham Sinha

Publikováno v: Physics of Fluids. 32:093308

Evaporation of drops almost always deposits their suspended particles at the drop edge. The dynamics of this process and the resulting patterns depend upon various parameters related to the liquid, substrate, and particles. An interesting scenario is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa1ea247110f3256eeaea85ae31b1279
https://doi.org/10.1063/5.0024078