Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Raju Kalaivani"'
Autor:
Chang Lu, Jan Zaucha, Rihab Gam, Hai Fang, Ben Smithers, Matt E. Oates, Miguel Bernabe-Rubio, James Williams, Natalie Zelenka, Arun Prasad Pandurangan, Himani Tandon, Hashem Shihab, Raju Kalaivani, Minkyung Sung, Adam J. Sardar, Bastian Greshake Tzovoras, Davide Danovi, Julian Gough
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Systematically predicting phenotypes or disease risks based on the information of an individual’s genetic variation remains an unsolved challenge. Here, the authors develop a knowledge-based approach for performing and evaluating hypothesis-free ph
Externí odkaz:
https://doaj.org/article/fe21f256cb6b4004bd97bf5b493f46e6
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 2, p e1005975 (2018)
The conserved function of protein phosphorylation, catalysed by members of protein kinase superfamily, is regulated in different ways in different kinase families. Further, differences in activating triggers, cellular localisation, domain architectur
Externí odkaz:
https://doaj.org/article/22791bbd5d50499e93252e43cef680d8
Publikováno v:
Rasayan Journal of Chemistry. 12:1166-1174
Sifuvirtide (SFT) is the second generation inhibitor of HIV-1 gp41 fusion protein, which is under phase III clinical trial for anti-HIV. However, over a period of time virus develops resistance against SFT. To overcome resistance, methionine and thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96eec06fc08307eb77f33a6f1dc6aedf
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:957-978
Our aim is to explore the similarities in structural fluctuations of homologous kinases. Gaussian Network Model based Normal Mode Analysis was performed on 73 active conformation structures in Ser/Thr/Tyr kinase superfamily. Categories of kinases wit
Autor:
Saima Wani, Raju Kalaivani, Deepash Kothiwal, Neelam Maharshi, Shikha Laloraya, Lakshmi Mahendrawada
Publikováno v:
Current genetics. 64(3)
Genomic stability is maintained by the concerted actions of numerous protein complexes that participate in chromosomal duplication, repair, and segregation. The Smc5/6 complex is an essential multi-subunit complex crucial for repair of DNA double-str
Publikováno v:
Proteins. 84(7)
Our aim is to explore the similarities in structural fluctuations of homologous kinases. Gaussian Network Model based Normal Mode Analysis was performed on 73 active conformation structures in Ser/Thr/Tyr kinase superfamily. Categories of kinases wit
Publikováno v:
Molecular bioSystems. 11(4)
We performed Gaussian network model based normal mode analysis of 3-dimensional structures of multiple active and inactive forms of protein kinases. In 14 different kinases, a more number of residues (1095) show higher structural fluctuations in inac
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:C1-C1